Biomedical subjects

Jan Wouters

Publications and source records attributed to Jan Wouters.

27 records · Page 2Linked to original sources

PubMed2004

Hearing assessment by recording multiple auditory steady-state responses: the influence of test duration.

The influence of test duration on the precision of hearing thresholds estimated by recording multiple auditory steady-state responses (ASSRs) was investigated. ASSR thresholds at four frequencies in both ears were assessed in 10 normal-hearing and 10 hearing-impaired subjects. The precision of the estimated hearing thresholds was compared for ASSR recordings of 5, 10 and 15 min per intensity level, corresponding to total test durations of approximately 30, 55 and 70 min for hearing-impaired ears. Furthermore, an intensity step size of 10 dB was compared to a step size of 5 dB. The mean difference scores averaged over the four frequencies were 15 +/- 10, 12 +/- 9 and 11 +/- 8 dB after recordings of 5, 10 and 15 min respectively. The corresponding Pearson correlation coefficients were 0.93, 0.95 and 0.96. Increasing the length of the separate recordings increases the precision of the estimates, independent of tested frequency. A compromise between both will have to be made. With a total test duration of approximately 1 h, four hearing thresholds in both ears can be estimated with a standard error of the estimate of 8 dB.

Adult↗

PubMed2004

Noise reduction results of an adaptive filtering technique for dual-microphone behind-the-ear hearing aids.

OBJECTIVE: The performance of an adaptive beam-former in a 2-microphone, behind-the-ear hearing aid for speech understanding in noisy environments was evaluated. Physical and perceptual evaluations were carried out. This was the first large-scale test of a wearable real-time implementation of this algorithm. The main perceptual research questions of this study were related to the influence on the noise reduction performance of (1) the spectro-temporal character of the jammer sound, (2) the jammer sound scene, (3) hearing impairment, and (4) the basic microphone configuration in the hearing aid. Four different speech materials were used for the perceptual evaluations. All tests were carried out in an acoustical environment comparable to living room reverberation. DESIGN: The adaptive beamformer was implemented in Audallion, a small, body-worn processor, linked to a Danasound 2-microphone behind-the-ear aid. The strategy was evaluated physically in different acoustical environments. Using speech reception threshold (SRT) measurements, the processing was evaluated perceptually and the different research questions addressed with three groups of subjects. Groups I, II, and III consisted of 10 normal-hearing, 5 hearing-impaired, and 7 normal-hearing persons, respectively. The tests were carried out in three spectro-temporally different jammer sounds (unmodulated and modulated speech weighted noise, multitalker babble) and in three different noise scenarios (single noise source at 90 degrees, noise sources at 90 degrees and 270 degrees relative to speaker position, diffuse noise scene). Two microphone configurations were compared: a device equipped with two omnidirectional microphones and a device equipped with one hardware directional and one omnidirectional microphone. In each of these conditions, the adaptive beamformer and the directional and omnidirectional microphone configurations were tested. RESULTS: The improvement in signal-to-noise ratio from the use of the adaptive beamformer did not depend on the spectro-temporal character of the jammer sounds and the speech materials used, although the absolute levels of the SRTs varied appreciably for different speech-noise combinations. The performance of the adaptive noise reduction depended on the jammer sound scene. CONCLUSIONS: No difference in signal-to-noise ratio improvement was observed between hearing-impaired and normal-hearing listeners, although individual SRT levels may differ. On average, an SRT improvement of 7.7 and 3.9 dB for a single noise source at 90 degrees and 5.9 and 3.4 dB for two noise sources at 90 degrees and 270 degrees was obtained for both normal-hearing and hearing-impaired listeners, using the adaptive beamformer and the directional microphone, respectively, relative to the omnidirectional microphone signal. In diffuse noise, only small improvements were obtained.

Adult↗

PubMed2004

Better speech perception in noise with an assistive multimicrophone array for hearing AIDS.

OBJECTIVE: To evaluate the improvement in speech intelligibility in noise obtained with an assistive real-time fixed endfire array of bidirectional microphones in comparison with an omnidirectional hearing aid microphone in a realistic environment. DESIGN: The microphone array was evaluated physically in anechoic and reverberant conditions. Perceptual tests of speech intelligibility in noise were carried out in a reverberant room, with two types of noise and six different noise scenarios with single and multiple noise sources. Ten normal-hearing subjects and 10 hearing aid users participated. The speech reception threshold for sentences was measured in each test setting for the omnidirectional microphone of the hearing aid and for the hearing aid in combination with the array with one and three active microphones. In addition, the extra improvement of five active array microphones, relative to three, was determined in another group of 10 normal-hearing listeners. RESULTS: Improvements in speech intelligibility in noise obtained with the array relative to an omnidirectional microphone depend on noise scenario and subject group. Improvements up to 12 dB for normal-hearing and 9 dB for hearing-impaired listeners were obtained with three active array microphones relative to an omnidirectional microphone for one noise source at 90 degrees . For three uncorrelated noise sources at 90 degrees, 180 degrees, and 270 degrees, improvements of approximately 9 dB and 6 dB were obtained for normal-hearing and hearing-impaired listeners, respectively. Even with a single noise source at 45 degrees, benefits of 4 dB were achieved in both subject groups. Five active microphones in the array can provide an additional improvement at 45 degrees of approximately 1 dB, relative to the three-microphone configuration for normal-hearing listeners. CONCLUSIONS: These improvements in signal-to-noise ratio can be of great benefit for hearing aid users, who have difficulties with speech understanding in noisy environments.

Adolescent↗

PubMed2004

Better place-coding of the fundamental frequency in cochlear implants.

In current cochlear implant systems, the fundamental frequency F0 of a complex sound is encoded by temporal fluctuations in the envelope of the electrical signals presented on the electrodes. In normal hearing, the lower harmonics of a complex sound are resolved, in contrast with a cochlear implant system. In the present study, it is investigated whether "place-coding" of the first harmonic improves the ability of an implantee to discriminate complex sounds with different fundamental frequencies. Therefore, a new filter bank was constructed, for which the first harmonic is always resolved in two adjacent filters, and the balance between both filter outputs is directly related to the frequency of the first harmonic. The new filter bank was compared with a filter bank that is typically used in clinical processors, both with and without the presence of temporal cues in the stimuli. Four users of the LAURA cochlear implant participated in a pitch discrimination task to determine detection thresholds for F0 differences. The results show that these thresholds decrease noticeably for the new filter bank, if no temporal cues are present in the stimuli. If temporal cues are included, the differences between the results for both filter banks become smaller, but a clear advantage is still observed for the new filter bank. This demonstrates the feasibility of using place-coding for the fundamental frequency.

Adult↗

PubMed2004

Relative contributions of temporal and place pitch cues to fundamental frequency discrimination in cochlear implantees.

The effect of the filter bank on fundamental frequency (F0) discrimination was examined in four Nucleus CI24 cochlear implant subjects for synthetic stylized vowel-like stimuli. The four tested filter banks differed in cutoff frequencies, amount of overlap between filters, and shape of the filters. To assess the effects of temporal pitch cues on F0 discrimination, temporal fluctuations were removed above 10 Hz in one condition and above 200 Hz in another. Results indicate that F0 discrimination based upon place pitch cues is possible, but just-noticeable differences exceed 1 octave or more depending on the filter bank used. Increasing the frequency resolution in the F0 range improves the F0 discrimination based upon place pitch cues. The results of F0 discrimination based upon place pitch agree with a model that compares the centroids of the electrical excitation pattern. The addition of temporal fluctuations up to 200 Hz significantly improves F0 discrimination. Just-noticeable differences using both place and temporal pitch cues range from 6% to 60%. Filter banks that do not resolve the higher harmonics provided the best temporal pitch cues, because temporal pitch cues are clearest when the fluctuation on all channels is at F0 and preferably in phase.

Adult↗

PubMed2003

Pitch of amplitude-modulated irregular-rate stimuli in acoustic and electric hearing.

The pitch of stimuli was studied under conditions where place-of-excitation was held constant, and where pitch was therefore derived from "purely temporal" cues. In experiment 1, the acoustical and electrical pulse trains consisted of pulses whose amplitudes alternated between a high and a low value, and whose interpulse intervals alternated between 4 and 6 ms. The attenuated pulses occurred after the 4-ms intervals in condition A, and after the 6-ms intervals in condition B. For both normal-hearing subjects and cochlear implantees, the period of an isochronous pulse train equal in pitch to this "4-6" stimulus increased from near 6 ms at the smallest modulation depth to nearly 10 ms at the largest depth. Additionally, the modulated pulse trains in condition A were perceived as being lower in pitch than those in condition B. Data are interpreted in terms of increased refractoriness in condition A, where the larger pulses are more closely followed by the smaller ones than in condition B. Consistent with this conclusion, the A-B difference was reduced at longer interpulse intervals. These findings provide a measure of supra-threshold effects of refractoriness on pitch perception, and increase our understanding of coding of temporal information in cochlear implant speech processing schemes.

Acoustic Stimulation↗

PubMed2002

Temporal pitch mechanisms in acoustic and electric hearing.

Two experiments investigated pitch perception for stimuli where the place of excitation was held constant. Experiment 1 used pulse trains in which the interpulse interval alternated between 4 and 6 ms. In experiment 1a these "4-6" pulse trains were bandpass filtered between 3900 and 5300 Hz and presented acoustically against a noise background to normal listeners. The rate of an isochronous pulse train (in which all the interpulse intervals were equal) was adjusted so that its pitch matched that of the "4-6" stimulus. The pitch matches were distributed unimodally, had a mean of 5.7 ms, and never corresponded to either 4 or to 10 ms (the period of the stimulus). In experiment 1b the pulse trains were presented both acoustically to normal listeners and electrically to users of the LAURA cochlear implant, via a single channel of their device. A forced-choice procedure was used to measure psychometric functions, in which subjects judged whether the 4-6 stimulus was higher or lower in pitch than isochronous pulse trains having periods of 3, 4, 5, 6, or 7 ms. For both groups of listeners, the point of subjective equality corresponded to a period of 5.6 to 5.7 ms. Experiment 1c confirmed that these psychometric functions were monotonic over the range 4-12 ms. In experiment 2, normal listeners adjusted the rate of an isochronous filtered pulse train to match the pitch of mixtures of pulse trains having rates of F1 and F2 Hz, passed through the same bandpass filter (3900-5400 Hz). The ratio F2/F1 was 1.29 and F1 was either 70, 92, 109, or 124 Hz. Matches were always close to F2 Hz. It is concluded that the results of both experiments are inconsistent with models of pitch perception which rely on higher-order intervals. Together with those of other published data on purely temporal pitch perception, the data are consistent with a model in which only first-order interpulse intervals contribute to pitch, and in which, over the range 0-12 ms, longer intervals receive higher weights than short intervals.

Adult↗

PubMed2002

Adaptive noise suppression for a dual-microphone hearing aid.

An adaptive beamformer for behind-the-ear dual-microphone hearing aids has been optimized for speech intelligibility enhancement in the presence of disturbing sounds or noise. The noise reduction approach is based on the scheme presented by Vanden Berghe and Wouters (1998). A real-time implementation of the signal processing is realized in Audallion, a wearable, small digital signal processing (DSP) platform. After physical evaluation, speech-in-noise intelligibility tests have been carried out on three normally-hearing and two hearing-impaired subjects. A significant speech reception threshold improvement of 11.3 dB was obtained in a moderately reverberant environment for one jammer sound source (steady speech-weighted noise or multi-talker babble) in a direction of 90 degrees relative to the direction of the speech.

Auditory Threshold↗

PubMedDate not supplied

New 3-deoxyanthocyanidins from leaves of Arrabidaea chica.

Two new 3-deoxyanthocyanidins, 6,7,3',4'-tetrahydroxy-5-methoxyflavylium and 6,7,4'-trihydroxy-5-methoxyflavylium, and the pigment carajurin, which has been previously identified, were isolated from dried leaves of Arrabidaea chica, a creeper native to the American tropics. The structures of the components were elucidated by 1H- and 13C-NMR spectroscopy and HPLC-MS, including X-ray crystallographic analysis for carajurin.

Anthocyanins↗