Biomedical subjects

Jan J Scicinski

Publications and source records attributed to Jan J Scicinski.

2 recordsLinked to original sources

PubMed2002

Analytical construct resins for analysis of solid-phase chemistry.

Rapid and unambiguous analysis of reactions performed on resin supports can be achieved by using "analytical constructs". These resins allow the synthesis of materials using solid-phase methods in the usual manner, but they also contain functionality enabling cleavage of analytically enhanced derivatives of the resin-bound products. This is possible due to the use of two linkers bound in series to the polymer. Cleavage at the first linker yields the products attached to an analytical enhancer that facilitates detection. Orthogonal cleavage at the second linker yields the desired products in the usual manner.

Coloring Agents↗

PubMed2002

Analytical techniques for small molecule solid phase synthesis.

Although resin-based chemistry offers many practical advantages over conventional solution phase for the synthesis of combinatorial libraries, effective monitoring of reactions conducted on the support remains a challenge. A number of techniques have been developed to enable the analysis of solid phase organic synthesis either by monitoring the resin-bound species directly or by the analysis of small quantities of material cleaved from the support. This review outlines some of the principles of the various techniques for the analysis of intermediates and products obtained from solid-phase chemistry.

Combinatorial Chemistry Techniques↗