Biomedical subjects

James Hardy

Publications and source records attributed to James Hardy.

5 recordsLinked to original sources

PubMed2006

Left ventricular assist device and drug therapy for the reversal of heart failure.

BACKGROUND: In patients with severe heart failure, prolonged unloading of the myocardium with the use of a left ventricular assist device has been reported to lead to myocardial recovery in small numbers of patients for varying periods of time. Increasing the frequency and durability of myocardial recovery could reduce or postpone the need for subsequent heart transplantation. METHODS: We enrolled 15 patients with severe heart failure due to nonischemic cardiomyopathy and with no histologic evidence of active myocarditis. All had markedly reduced cardiac output and were receiving inotropes. The patients underwent implantation of left ventricular assist devices and were treated with lisinopril, carvedilol, spironolactone, and losartan to enhance reverse remodeling. Once regression of left ventricular enlargement had been achieved, the beta2-adrenergic-receptor agonist clenbuterol was administered to prevent myocardial atrophy. RESULTS: Eleven of the 15 patients had sufficient myocardial recovery to undergo explantation of the left ventricular assist device a mean (+/-SD) of 320+/-186 days after implantation of the device. One patient died of intractable arrhythmias 24 hours after explantation; another died of carcinoma of the lung 27 months after explantation. The cumulative rate of freedom from recurrent heart failure among the surviving patients was 100% and 88.9% 1 and 4 years after explantation, respectively. The quality of life as assessed by the Minnesota Living with Heart Failure Questionnaire score at 3 years was nearly normal. Fifty-nine months after explantation, the mean left ventricular ejection fraction was 64+/-12%, the mean left ventricular end-diastolic diameter was 59.4+/-12.1 mm, the mean left ventricular end-systolic diameter was 42.5+/-13.2 mm, and the mean maximal oxygen uptake with exercise was 26.3+/-6.0 ml per kilogram of body weight per minute. CONCLUSIONS: In this single-center study, we found that sustained reversal of severe heart failure secondary to nonischemic cardiomyopathy could be achieved in selected patients with the use of a left ventricular assist device and a specific pharmacologic regimen.

Adolescent↗

PubMed2006

Minimally invasive technique for explantation of right ventricular assist devices.

In an attempt to reduce some or all of the complications resulting from the use of biventricular assist devices after mechanical circulatory support, we have developed and applied a minimally invasive technique for explantation of right ventricular assist devices.

Device Removal↗

PubMed2005

Quantifying athlete self-talk.

Two studies were conducted. The aims of Study 1 were (a) to generate quantitative data on the content of athletes' self-talk and (b) to examine differences in the use of self-talk in general as well as the functions of self-talk in practice and competition settings. Differences in self-talk between the sexes, sport types and skill levels were also assessed. Athletes (n = 295, mean age = 21.9 years) from a variety of sports and competitive levels completed the Self-Talk Use Questionnaire (STUQ), which was developed specifically for the study. In Study 1, single-factor between-group multivariate analyses of variance revealed significant differences across sex and sport type for the content of self-talk. Mixed-model multivariate analyses of variance revealed overall greater use of self-talk, as well as increased use of the functions of self-talk, in competition compared with practice. Moreover, individual sport athletes reported greater use of self-talk, as well as the functions of self-talk, than their team sport counterparts. In Study 2, recreational volleyball players (n = 164, mean age = 21.5 years) completed a situationally modified STUQ. The results were very similar to those of Study 1. That the content of athlete self-talk was generally positive, covert and abbreviated lends support to the application of Vygotsky's (1986) verbal self-regulation theory to the study of self-talk in sport. Researchers are encouraged to examine the effectiveness of self-talk in future studies.

Adult↗

PubMed2004

Effect of left ventricular assist device combination therapy on myocardial blood flow in patients with end-stage dilated cardiomyopathy.

BACKGROUND: Changes in myocardial blood flow (MBF) and coronary flow reserve (CFR) are independent prognostic risk factors in idiopathic dilated cardiomyopathy (DCM). The aim of this study was to assess the impact of left ventricular unloading using left ventricular assist device (LVAD) combination therapy on resting MBF and CFR in patients with end-stage heart disease. METHODS: We studied 11 patients with deteriorating end-stage DCM (New York Heart Association Class 4) treated with LVAD support combined with pharmacologic therapy in a recovery program. Absolute MBF was measured using oxygen-15-labeled water (H(2)(15)O) positron emission tomography (PET) at rest during LVAD support and 15 minutes after the LVAD was switched off. Data were corrected for rate pressure product (RPP) when appropriate. Hyperemic MBF (intravenous adenosine, 140 mug/kg . min) was also measured in 6 patients with the LVAD switched off. CFR was calculated as the ratio MBF adenosine/MBF LVAD off (corrected). Data are expressed as mean +/- SD. RESULTS: At 317 +/- 193 days after device implantation, resting MBF was 0.95 +/- 0.29 (LVAD on) and 1.46 +/- 0.62 (LVAD off, corrected) ml/min . g (p = 0.01). MBF (LVAD on) was comparable with that of 11 age- and gender-matched normal controls (1.09 +/- 0.22 ml/min . g). CFR in the LVAD group was 1.49 +/- 0.99 compared with 3.56 +/- 1.42 in normal controls (p < 0.01). CONCLUSIONS: During LVAD support, resting MBF (LVAD on) was comparable to MBF in normal controls and increased when the LVAD was switched off. However, CFR was significantly impaired, even though all patients studied showed varying degrees of myocardial recovery. The implications of these findings, particularly in the long term, require further study.

Adolescent↗

PubMedDate not supplied

Abdominal apoplexy: a case study of the spontaneous rupture of the gastroepiploic artery.

This is a case report of abdominal apoplexy (AA) or spontaneous rupture of a visceral vessel, without associated aneurysmal dilation of the vessel. Spontaneous rupture of the left gastroepiploic artery (LGEA) resulting in a hemoperitoneum is discussed. The clinical presentation of left lower quadrant abdominal pain, along with the histologic findings of medial degeneration of the LGEA, makes this case an unusual one. The incidence, origin, associated predisposing medical conditions, clinical presentation, and treatment of abdominal apoplexy are discussed.

Abdomen, Acute↗