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Biomedical subjects

James F Greenleaf

Publications and source records attributed to James F Greenleaf.

41 records · Page 3Linked to original sources

Detection of calcium deposits on heart valve leaflets by vibro-acoustography: an in vitro study.

The presence of calcium deposits on heart valve leaflets constitutes a clinically significant diagnostic indication. A novel method for imaging and detecting calcium deposits on tissue heart valves is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate the tissue at low (kHz) frequency and records the resulting acoustic response to produce images that are related to the hardness of the tissue. The method is tested on excised human heart valve tissues. Resulting images clearly show calcium deposits with high contrast and are in agreement with the corresponding radiographs of the specimens.

Algorithms↗

Vibro-acoustic tissue mammography.

A novel method for detection and imaging of microcalcifications in breast tissue is presented. The method, called vibro-acoustography, uses the radiation force of ultrasound to vibrate tissue at low (kHz) frequency and utilizes the resulting response to produce images that are related to the hardness of the tissue. The method is tested on human breast tissues. The resulting vibro-acoustographic images are in agreement with corresponding X-ray mammography images of the specimens. The existence of microcalcifications in locations indicated by vibro-acoustography is confirmed by histology. Microcalcifications as small as 110 microm in diameter are detected by this method. Resulting vibro-acoustographic images show microcalcifications with high contrast with respect to the background soft tissue. Structures such as dense sclerotic tissue do not seem to interfere with detection of microcalcifications.

Breast Neoplasms↗

Optical measurement of ultrasonic Poynting and velocity vector fields.

This report describes a method for estimating several wide bandwidth ultrasonic field parameters from optical measurements of the local, acoustically induced, refractive index perturbation in water. These parameters include Poynting and particle velocity vector fields as well as pressure and density fields at any temporal delay under mild (forward-propagating) assumptions on the angular plane-wave spectrum of the ultrasound field. A sampling theorem is derived stating that two complete measurements of the three-dimensional pressure field separated in time by delta t allow release of the forward-propagating assumption for every acoustic wave number k satisfying k not = n pi/(c delta t), where c is the acoustic wave speed in the medium and n an integer greater than zero. The approach provides detailed measurements of very general ultrasound fields. Two optical measurement methods that acquire the Radon transform of the three-dimensional refractive index perturbation are briefly reviewed. It is shown that the Radon transform of the field itself satisfies a two-dimensional wave equation and may be propagated independently forward or backward in time under a source-free model. Conversely, the Radon transform of the ultrasound field measurement at several known time delays provides a means of applying a filter to the data based on known ultrasound propagation models. Each two-dimensional distribution may be propagated to a common time point and the ensemble averaged, thus incorporating the propagation model into the measurement. We support the presented theory with several experiments.

Journal Article↗

Characterization of reperfused infarcted myocardium from high-frequency intracardiac ultrasound imaging using homodyned K distribution.

Myocardial changes caused by infarction/reperfusion (contraction band necrosis, hemorrhage, edema, etc.) may result in an increased scatterer density and a variation in scatterer arrangement. This paper, for the first time, models most of the scattering conditions resulting from the interaction of ultrasound and normal/reperfused infarcted myocardium using the homodyned K distribution. Furthermore, this method is used to characterize the change in scatterer density by calculating the effective scatterer number per resolution cell. The reliability and the effects of attenuation and scan conversion on effective scatterer number estimation are discussed. We used in vivo data acquired using high-frequency intracardiac ultrasound imaging (8.5 MHz) from the left and right ventricles of open-chest pigs in an acute infarction/reperfusion model. The results show that the homodyned K distribution describes the statistical distribution of backscattered signal from both normal and abnormal myocardium. A significant increase in scatterer density occurs in the infarcted region after reperfusion compared with the same region at baseline (normal myocardium prior to occlusion). The scatterer density of the normal region does not change significantly after reperfusion. We conclude that the homodyned K distribution may characterize normal and reperfused infarcted myocardium using high-frequency intracardiac ultrasound images.

Animals↗

Remote measurement of material properties from radiation force induced vibration of an embedded sphere.

A quantitative model is presented for a sphere vibrated by two ultrasound beams of frequency omega1 and omega2. Due to the interference of two sound beams, the radiation force has a dynamic component of frequency omega2-omega1. The radiation impedance and mechanical impedance of the sphere are then used to compute the vibration speed of the sphere. Vibration speed versus vibration frequency is measured by laser vibrometer on several spheres, both in water and in gel phantom. These experimental results are used to verify the model. This method can be used to estimate the material properties of the medium (e.g., shear modulus) surrounding the sphere.

Elasticity↗