Biomedical subjects

Jaehoon Seong

Publications and source records attributed to Jaehoon Seong.

4 recordsLinked to original sources

PubMed2005

Morphological age-dependent development of the human carotid bifurcation.

The unique morphology of the adult human carotid bifurcation and its sinus has been investigated extensively, but its long-term, age-dependent development has not. It is important fundamentally and clinically to understand the hemodynamics and developmental forces that play a role in remodeling of the carotid bifurcation and maturation of the sinus in association with brain maturation. This understanding can lead to better prognostication and therapy of carotid disease. We analyzed the change of sinus morphology and the angle of the carotid bifurcation in four postnatal developmental stages (Group I: 0-2 years, Group II: 3-9 years, Group III: 10-19 years, and Group IV: 20-36 years, respectively) using multiprojection digital subtraction angiograms and image post-processing techniques. The most significant findings are the substantial growth of the internal carotid artery (ICA) with age and the development of a carotid sinus at the root of the ICA during late adolescence. The bifurcation angle remains virtually unchanged from infancy to adulthood. However, the angle split between the ICA and external carotid artery (ECA) relative to the common carotid artery (CCA) undergoes significant changes. Initially, the ICA appears to emanate as a side branch. Later in life, to reduce hydraulic resistance in response to increased flow demand by the brain, the bifurcation is remodeled to a construct in which both daughter vessels are a skewed continuation of the parent artery. This study provides a new analysis method to examine the development of the human carotid bifurcation over the developmental years, despite the small and sparse database. A larger database will enable in the future a more extensive analysis such as gender or racial differences.

Adolescent↗

PubMed2005

Functional angiography.

The discovery of X-rays over a century ago enabled noninvasive examination of the human body. Contrast agents that enhanced X-ray images were soon developed that advanced angiology by allowing exploration of the vascular tree. Starting as a diagnostic tool, angiography underwent technological transformations over the last century and became a basis for interventional therapy as well. Initially a static two-dimensional record of the vasculature on screen films, angiography has evolved to real-time two-dimensional display of the vasculature on television monitors, three-dimensional reconstruction from computerized tomographic (CT) scans, and, more recently, three-dimensional cone-beam reconstruction. Cinematographic angiography is referred to as dynamic angiography in current terminology, but it essentially provides no more than images of vascular structures and changes therein. Although dynamic angiography has facilitated advances in image-guided interventions, the evaluation of blood flow rate, or perfusion, and blood flow velocity using angiography remains elusive. Many lines of research have been pursued toward enabling such evaluations, but none have found their way into clinical practice. This article reviews angiographic flow assessment methods attempted over the past several decades and explores some new avenues that may facilitate the transfer of such methods into the clinical practice of diagnostic and interventional angiography and, eventually, contribute to better patient care.

Angiography↗

PubMed2005

Morphology of elastase-induced cerebral aneurysm model in rabbit and rapid prototyping of elastomeric transparent replicas.

In this work, we describe a methodology to fabricate transparent elastomeric vascular replicas using rapid prototyping techniques. First, the three-dimensional morphology of an elastase-induced aneurysm model in rabbit is acquired. The morphology is reconstructed from in vivo rotational angiography and it is compared with three-dimensional reconstructions obtained by computerized tomography and magnetic resonance imaging of an intraluminal arterial cast that was obtained from the same animal at sacrifice. Results show that resolution of the imaging modality strongly influences the level of detail, such as small side branches, in the final reconstruction. We developed an average morphology model for elastase-induced aneurysms in rabbits including the surrounding vasculature and describe a method for rapid prototyping of vascular models from the three-dimensional morphology. Our replicas can be manufactured in a short period of time and the final product is optically clear. In addition, the elasticity of the models can be controlled to represent arterial elasticity, which makes them ideal for optical investigations of detailed flow dynamics using measurement tools such as particle image velocimetry.

Animals↗

PubMed2004

Hemodynamics of carotid artery atherosclerotic occlusive disease.

Hemodynamic mechanisms for the initiation and progression of carotid bifurcation atherosclerotic occlusive disease have been extensively researched during the past few decades. Attention has focused on the carotid bulb, or sinus, where most atherosclerotic plaques are found. Herein, the authors review the seminal works that have led to an understanding of not only complex local hemodynamics but also the elicited specific biologic response. In addition, new analysis of the age-dependent morphologic maturation of the human carotid bifurcation is unveiled. Understanding the role of hemodynamics in atherogenesis may lead to the improvement of minimally invasive endovascular therapy and noninvasive strategies.

Brain↗