Supramolecular amphiphiles: spontaneous formation of vesicles triggered by formation of a charge-transfer complex in a host.
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Journal Article↗
Biomedical subjects
Jae Wook Lee
Publications and source records attributed to Jae Wook Lee.
Unprecedented host-induced intramolecular charge-transfer complex formation.
For the first time, host-induced intramolecular charge-transfer complex formation in a guest containing both an electron donor and an electron acceptor is demonstrated in the cucurbit[8]uril cavity, leading to unusual back-folding of the guest molecule.
Journal Article↗
A novel microtubule destabilizing entity from orthogonal synthesis of triazine library and zebrafish embryo screening.
The first orthogonal combinatorial synthesis of a high-purity triazine library was demonstrated. Novel triazine-based microtubule inhibitors were discovered by an efficient zebrafish embryo screening and in vitro microtubule polymerization assay.
Animals↗
Purine-based inhibitors of inositol-1,4,5-trisphosphate-3-kinase.
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Adenosine Triphosphate↗
Synthesis and evaluation of taxol-folic acid conjugates as targeted antineoplastics.
A series of Taxol derivatives tethered at C2' and C-7 to glutamate and folate have been synthesized for evaluation as prodrugs which release Taxol via hydrolytic lability of their alpha-alkoxy and alpha-amino esters. The half-time for hydrolysis of these materials was determined in pH 7 and pH 5 buffer. The in vitro cytotoxicity has been assessed in cell culture against A-549 lung cancer, MCF-7 breast cancer, and HT-29 colon cancer. Selected agents were further screened for folate binding and competitive binding with free folic acid. One agent (54), further evaluated in animal studies was found to increase the lifespan in mice, but was less effective than Taxol itself.
Antineoplastic Agents↗
Novel Pseudorotaxane-Terminated Dendrimers: Supramolecular Modification of Dendrimer Periphery We gratefully acknowledge the Korean Ministry of Science and Technology (Creative Research Initiative Program) for support of this work, and Professor P. K. Bharadwaj for reading the manuscript.
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Journal Article↗
Self-assembled ternary complex of cationic dendrimer, cucurbituril, and DNA: noncovalent strategy in developing a gene delivery carrier.
A ternary complex of PPI-DAB dendrimer [(1,4-diaminobutane); Gen = N; dendri-poly(propyleneimine); -[NHC(=O)CH(2)NH(2)(+)(CH(2))(4)NH(3)(+)](z)()], DNA, and cucurbituril (CB) was evaluated as an example of a totally self-assembled gene delivery carrier. The complex was formed in a noncovalent way in which DNA interacts with PPI-DAB electrostatistically and CB with PPI-DAB through multiple noncovalent interactions. Dynamic light scattering data indicated that the diameter and size distributions of the complexes were dependent upon the sequence of mixing of each component with unimodal distribution ranging from 150.8 to 210.2 nm under favorable conditions. Fluorescence studies showed the quantitative binding of CB to PPI-DAB after ternary complex formation. The complex was able to transfect mammalian cells with high efficiency and the cytotoxicity of the PPI-DAB/CB complex was relatively low.
Animals↗
Nitrophenol resins for facile amide and sulfonamide library synthesis.
Novel nitrophenol solid supports based on various resin materials (polystyrene, TentaGel, macroporous, PEGA, and silica gel) are reported for facile amide and sulfonamide library synthesis. The broad choice of resin materials available will allow the reaction to occur successfully in solvents ranging from nonpolar organic solvents to aqueous media.
Journal Article↗