Solid-phase synthesis of the biologically active N-terminal 1 - 34 peptide of human parathyroid hormone.
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Animals↗
Biomedical subjects
J van Rietschoten
Publications and source records attributed to J van Rietschoten.
Characterization of five neurotoxins isolated from the venoms of two Elapidae snakes Naja haje and Naja nigricollis.
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Amino Acid Sequence↗
Proceedings: Structural requirements for biological activity of parathyroid hormone defined by study of synthetic peptides.
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Amino Acid Sequence↗
Specificity of anti-peptide antibodies elicited against synthetic peptides mimicking conserved regions of HIV1 envelope glycoprotein.
Comparison of HIV1Bru and HIV2Rod external envelope glycoprotein sequences enabled us to select ten highly conserved peptide sequences. The corresponding peptides were chemically synthesized, then coupled to bovine serum albumin before injection in rabbits. Although all peptides were immunogenic, only antibodies directed against peptides P1 (amino acid residues 33-55), P22 (418-462), P8 (487-508) and P21 (487-534) were able to interact with significant affinity (K0.5 about 10(-6) to 10(-8) M) with the native glycoprotein by radioimmunoassay. Noteworthy was the capacity of anti-P1 antibodies to also recognize the glycoprotein of HIV2. Anti-peptide antibodies were tested for their ability to interfere with the gp120-CD4 interaction, membrane fusion and virus replication. Preincubation of gp120 with antibodies directed to the region previously described as the putative CD4-binding site, P22 (418-462), did not abolish gp120 binding to CD4-positive cells.
Amino Acid Sequence↗
Chemical and biologic studies of proparathyroid hormone and parathyroid hormone: analysis of hormone biosynthesis and metabolism.
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Amino Acid Sequence↗