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Biomedical subjects

J van Eyck

Publications and source records attributed to J van Eyck.

At least 37 records · Page 2Linked to original sources
PubMed1998

Evaluation of the iron status of the newborn by soluble transferrin receptors in serum.

The concentration of soluble transferrin receptors in serum has proven to be a reliable predictor of iron status in adults. Its high sensitivity for iron deficiency combined with a small sample size (10 microliters) makes it an interesting parameter for the assessment of iron stores in newborn infants. In the present study we investigated the usefulness of the concentration of soluble transferrin receptors in serum in the assessment of iron metabolism in the newborn. Infants born after an uncomplicated labour were compared to infants in the intensive care unit. The concentration of soluble transferrin receptors in serum was found to be elevated compared to normal adults and independently of iron metabolism. The concentration of soluble transferrin receptors did not correlate with serum iron and ferritin concentrations. In contrast to what was found in other studies, no relationship could be demonstrated between soluble transferrin receptors and birth weight or gestational age. The results of this study have shown that care has to be taken in the interpretation of the concentration of soluble transferrin receptors in serum in newborn infants. It seems to be a parameter which is independent of iron metabolism at least during the first days of life.

Adult↗
PubMed1997

Restrictive dermopathy and associated prenatal ultrasound findings: case report.

Restrictive dermopathy is a lethal autosomal recessive skin disease. Prenatal diagnosis has not yet been reported. We present a case of restrictive demography and describe the associated prenatal sonographic findings. A continuously open mouth was the most striking feature and this sonographic finding may be a marker of a skin disease.

Abnormalities, Multiple↗
PubMed1997

Maternal position and ultrasonic cervical assessment in multiple pregnancy. Preliminary observations.

OBJECTIVE: To evaluate the influence of position on the functional anatomy of the cervix. STUDY DESIGN: Cervical length and width of the internal os were measured by transvaginal ultrasound in the recumbent and standing position from 15 gestational weeks to term in 15 twin and 3 triplet pregnancies. Measurements on asymptomatic primigravidae with twins who delivered vaginally after 36 weeks were made to calculate trends in normal twin pregnancies. These data were compared with that obtained in patients who had threatened preterm labor. RESULTS: As the total observation period progressed, the mean cervical length decreased from 50 to 27 mm in the recumbent position and from 48 to 21 mm in the standing position (P < .001). The differences between the values obtained in the recumbent and standing position increased from 5% to 31% as pregnancy progressed (P < .001). Funnelling was observed from 20 weeks onwards in the erect position but only after 35 weeks in the recumbent position. CONCLUSION: Our preliminary observations support a policy aimed at prevention of prematurity by reducing physical activity and standing work in patients who have multiple gestations. The full impact of these observations on the early detection of special risk groups and the prescription of preventive interventions have yet to be evaluated.

Cervix Uteri↗
PubMed1997

Nicotine and caffeine. Influence on prenatal hemodynamics and behavior in early twin pregnancy.

OBJECTIVE: To evaluate the effect of nicotine and caffeine in early multiple pregnancies. STUDY DESIGN: Ten women with twin pregnancies volunteered to take part in the study. Five mothers smoking > 5 cigarettes/d were investigated before and after smoking. Five women were investigated before and after drinking coffee. Maternal hemodynamics, umbilical blood flow, fetal heart rate and twin behavior were longitudinally documented during a 30-minute session from 8 to 16 gestational weeks. Fetal behavior was analyzed from videotapes using a one-minute window. RESULTS: The mean increase in maternal heart rate after smoking was 10 bpm (P < .005). After drinking coffee, it was 8 bpm (P < .01). The pulsatility index of the umbilical artery showed a significant increase after smoking (P < .01). After coffee the increase was also significant (P < .05). Two of five behavioral parameters (swallowing and breathing) demonstrated significant changes after the consumption of coffee (P < .001). CONCLUSION: This pilot study demonstrated significant effects of nicotine and caffeine consumption on maternal and fetal hemodynamics. It seems worthwhile to study the influences of smoking and coffee consumption on early twin behavior in larger samples.

Adult↗
PubMed1996

The onset of inter-human contacts: longitudinal ultrasound observations in early twin pregnancies.

Twin pregnancies provide us with the opportunity to observe first reactions towards touch in utero, and this study illustrates the onset and development of these contacts. Forty women with twin pregnancies volunteered to take part in this study, 25 of whom (five monochorionic, 20 dichorionic pairs) fulfilled the inclusion criteria. Between 8 and 12 weeks' gestation, ultrasound examinations were performed transvaginally, and from 13 weeks onwards transabdominally, at weekly intervals. Ultrasound findings were recorded on videotapes and were analyzed retrospectively. The first contacts producing reactions in the co-twin were defined as primary contacts, which could be slow or fast arm/leg/head/body contacts. Primary contacts followed an action-reaction model, and usually lasted < 3 s. These contacts were initially slow and then became fast. The first reactions of the co-twin towards touch were observed at 65 postmenstrual days. Contacts of longer duration between both bodies including extremities, or contacts initiated by sucking movements towards the co-twin were defined as complex contacts and were observed from 85 and 92 post-menstrual days, respectively. Nearly all contacts occurred significantly earlier in monochorionic compared to dichorionic twins. Female/female pairs seemed to develop complex body contacts earlier than male/male pairs, but for the onset of other contacts we have not yet found significant differences between gender combinations.

Age of Onset↗
PubMed1996

Fetal death of one twin in a monochorionic pregnancy with twin-twin transfusion syndrome.

BACKGROUND: Twin-twin transfusion syndrome (TTTS) occurs in 5-30% of all monochorionic pregnancies. The mortality and morbidity rates are high and therapeutic options limited. CASE: TTTS in a monochorionic twin pregnancy was initially diagnosed by differences in amniotic fluid volume at 26 weeks. No signs of atrioventricular valve insufficiency or nonimmune hydrops fetalis were present in the recipient. Despite this, the recipient died in utero, whereupon the condition of the donor improved markedly. After spontaneous delivery at 30 weeks' gestation, coarctation of the umbilical cord at its insertion was observed in the recipient, probably secondary to severe torsion. CONCLUSION: Unexpected obstetric events may occur in already-complicated pregnancies that are not related to a specific condition, its diagnosis or its therapy.

Adult↗
PubMed1995

[Postpartum complication: 'postpartum headache' (thrombosis of the superior sagittal sinus)].

A 34-year-old woman was admitted on the 10th day post partum complaining of loss of strength in the left arm and headache. The next day she started having seizures. Although the clinical picture suggested sinus thrombosis, initially a CT scan showed no abnormalities. The diagnosis of sinus sagittalis superior thrombosis was finally made by means of arteriography. The patient was treated successfully with anticoagulants and recovered without sequelae.

Acenocoumarol↗
PubMed1993

Antenatal diagnosis of vasa previa by transvaginal color Doppler sonography.

Vasa previa is a rare complication of pregnancy with a high perinatal mortality, which has virtually not changed over the last 200 years. In this case report we describe the use of color Doppler ultrasonography to make a correct antepartum diagnosis of vasa previa. The baby was delivered by Cesarean section. A strategy is presented which may reduce the high mortality rate from this condition.

Journal Article↗
PubMed1992

Actocardiotocographic monitoring of triplets during vaginal delivery.

A case is reported in which fetal monitoring during vaginal delivery of triplets was performed with the MT 430 actocardiotocograph. This method provides optimal monitoring of multiple pregnancies because the fetal heart rate tracings of three fetuses, together with recordings of fetal movements and uterine contractions, can be visualized on one display.

Adult↗
PubMed1991

Human fetal foramen ovale flow velocity waveforms relative to fetal breathing movements in normal term pregnancies.

The relationship between foramen ovale flow velocity waveforms and high-amplitude fetal breathing movements was studied in ten normal term pregnancies using Doppler ultrasonography. Peak systolic and averaged flow velocities demonstrated a statistically significant increase during fetal breathing activity, suggesting a raised pressure gradient between the right and left atria. This could be explained by a temporal reduction in pulmonary venous return to the left atrium during the inspiratory phase of the fetal breathing cycle. The breathing-related increase in foramen ovale flow velocity suggests that fetal breathing activity facilitates the distribution of well-oxygenated blood to the aorta and cerebral circulation.

Journal Article↗
PubMed1991

[Effect of fetal behavioral reactions and respiratory movements on the blood flow in the ductus arteriosus].

Relationship between blood flow velocity waveform and fetal behavioral states was studied in 16 normal pregnancies at 37 to 38 weeks' gestation. The peak flow velocity has demonstrated a statistically significant reduction during active sleep, as against that in quite sleep. These data reflect reduced ductal flow and suggest a redistribution in the left-ventricular and right-ventricular output in favor of the left side of the heart during active sleep. In a prospective cross-sectional study of 49 pregnancies (50 fetuses) between 25th and 38th weeks an exponential increase in breathing-related ductal blood flow velocity modulation was observed with advancing gestational age, reflecting the developing pulmonary vascular bed. Fetal ductal flow velocity waveforms were also recorded in 13 cases of prolonged severe oligohydramnios after membrane rupture before 28 weeks' gestation. Normal ductal blood flow velocity modulation values were associated with normal neonatal lung performance, whereas reduced blood flow velocity modulation values were associated with pulmonary hypoplasia. Fetal breathing-related ductal flow velocity modulation appears to be a promising predictor of neonatal lung performance.

Aorta, Thoracic↗
PubMed1990

Human fetal foramen ovale flow velocity waveforms relative to behavioral states in normal term pregnancy.

In 16 normal pregnancies the relationship between foramen ovale flow velocity waveforms and fetal behavioral states at 37 to 38 weeks' gestation was studies with Doppler techniques. Foramen ovale flow velocity waveforms are characterized by a typical systolic/diastolic component. Average flow velocity was statistically significantly increased in behavioral state 2F (active sleep) as compared with state 1F (quiet sleep), which was mainly determined by an increase in flow velocity during the end-systolic and passive atrial filling phase. The increase in the average flow velocity at the foramen ovale level during active sleep suggests a redistribution of blood flow at the cardiac level, resulting in an increased right-to-left shunt.

Blood Flow Velocity↗
PubMed1990

Ductus arteriosus flow velocity modulation by fetal breathing movements as a measure of fetal lung development.

A test is needed that would accurately predict favorable neonatal lung performance in the presence of prolonged severe oligohydramnios caused by ruptured membranes so that optimal obstetric care can be provided. We propose such a test that is based on the degree of modulation of fetal ductal blood flow velocity by fetal breathing movements after maternal glucose loading. In a prospective cross-sectional study of 49 normal pregnancies (50 fetuses) between 25 and 38 weeks an exponential increase in breathing-related ductal blood flow velocity modulation was observed with advancing gestational age, reflecting the developing pulmonary vascular bed. Fetal ductal flow velocity waveforms were also recorded in 13 cases of prolonged severe oligohydramnios after ruptured membranes before 28 weeks' gestation. Normal ductal blood flow velocity modulation values were associated with normal neonatal lung performance, whereas reduced ductal blood flow velocity modulation values were associated with pulmonary hypoplasia. Fetal breathing-related ductal flow velocity modulation appears to be a promising predictor of neonatal lung performance.

Adult↗
PubMed1989

Trisomy 18 in monozygotic twins.

We report a very rare case of a pair of monozygotic twins with trisomy 18 discordant for major anomalies. Our case contributes to published data on the role of nongenetic factors in the etiology of discordance of congenital malformations in genotypically identical twins. We stress the importance of accurate ultrasonic examination in reducing the number of caesarean sections to deliver trisomy 18 infants.

Adult↗
PubMed1989

Human fetal ductal flow velocity waveforms relative to behavioral states in normal term pregnancy.

In 16 normal pregnancies the relationship between the blood flow velocity waveform and fetal behavioral states at 37 to 38 weeks' gestation was studied. Whereas behavioral state independency was established for the acceleration time, peak flow velocity demonstrated a statistically significant reduction during active sleep, compared with quiet sleep. These data reflect reduced ductal flow and suggest a redistribution in the left-ventricular and right-ventricular output in favor of the left side of the heart during active sleep. Peak flow velocities in the fetal ductus arteriosus were independent of fetal heart rate.

Blood Flow Velocity↗
PubMed1989

Flow velocity waveforms in the fetal internal carotid artery relative to fetal blood gas and acid-base measurements in normal pregnancy.

Flow velocity waveforms in the fetal internal carotid artery during fetal behavioural state 2F were compared with blood gas and acid-base data from fetal scalp blood samples immediately following artificial rupture of the membranes in 17 normal term pregnancies. The pulsatility index in the fetal internal carotid artery was positively related to PO2 and base excess suggesting that also under physiological conditions fetal cerebral vascular resistance may respond to changes in fetal oxygenation.

Acid-Base Equilibrium↗