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Biomedical subjects

J de Boer

Publications and source records attributed to J de Boer.

136 records · Page 8Linked to original sources
PubMedDate not supplied

Public health measures following a nuclear accident in The Netherlands.

The Dutch government has set up a project on public health measures to be followed in the event of a nuclear accident or disaster. The project includes curative and preventive measures, together known as direct measures. This article summarizes the curative measures to be used both on-site and in the action zone, during transportation, and in the hospital Accident and Emergency Department. Preventive measures including public information, sheltering, iodine prophylaxis, decontamination, evacuation, and the use of supportive nuclear teams are also discussed.

Accidents↗
PubMedDate not supplied

Cancer from the outside, aging from the inside: mouse models to study the consequences of defective nucleotide excision repair.

In recent years, mouse models have been generated to study the syndromes associated with a defect in nucleotide excision repair (NER). Thus, via conventional knockout gene targeting or by mimicking patient-specific alleles, mouse models for xeroderma pigmentosum (XP), Cockayne syndrome (CS) and photosensitive trichothiodystrophy (TTD) have been obtained. The generation of this series of mouse mutants allows in vivo investigation of some intriguing questions that have puzzled the field, such as the paradoxical absence of cancer development in TTD and CS despite their NER deficiencies, and the role of the ERCC1 gene in mitotic recombination and cross-link repair. Other interesting issues include the pathophysiology of the non-NER related clinical symptoms in TTD and CS patients and the proposed involvement of NER and transcription in the process of aging. This review will focus on data obtained thus far and discuss further utilization of the mouse mutants for unraveling some of the fascinating and medically relevant aspects associated with defects in NER and related processes.

Aging↗
PubMedDate not supplied

Criteria for the assessment of disaster preparedness--II.

By defining the chain of medical care and the capacities of the successive phases within this chain, an attempt is made to analyze and grade the determinants of these capacities. In this way, calculations that indicate overall disaster preparedness can be expressed in a figure ranging from 1-5. The capacity of the system is taken as the lowest score obtained for the components of the system. The methodology used for this assessment of preparedness is described and an example is used to show the efficacy of this methodology.

Disaster Planning↗
PubMedDate not supplied

An attempt at more accurate estimation of the number of ambulances needed at disasters in The Netherlands.

A more accurate estimate of the number of ambulances needed at disasters prevents vehicles from being withdrawn unnecessarily from their "normal" duties, thereby curtailing needless expense and helping to ensure that disaster sites are not overcrowded with emergency workers impeding each other's effectiveness. This article discusses a formula for determining the number of ambulances needed at a disaster.

Ambulances↗
PubMedDate not supplied

Medical disaster preparedness of Rotterdam-Europort: an application of methodology for assessing disaster preparedness.

Medical disaster preparedness (MDP) of Rotterdam-Europort has been estimated by grading personnel, materials, and methods utilized in the chain of medical care, from the disaster site to the hospital. On a scale from 1 to 5, this MDP was set at 2.8: the disaster site is the weakest link, which determines the strength of the whole chain. This, in turn, was the result mainly of the methods utilized for which the personnel were not properly educated and trained. By applying the methodology as described in an earlier paper, the MDP of cities, airports, harbors, industrial plants, etc. can be determined in a standardized way. This methodology should facilitate epidemiologic research in the public health aspects of disaster preparedness.

Aircraft↗
PubMedDate not supplied

Determination of chlorobiphenyls in cleaned-up seal blubber and marine sediment extracts: interlaboratory study.

An interlaboratory study on the determination of individual chlorobiphenyl congeners (CBs) in cleaned-up seal blubber and marine sediment extracts was organized by the International Council for Exploration of the Sea, the Intergovernmental Oceanographic Commission, and the Oslo and Paris Commissions, as the second part of a step-wise-designed interlaboratory study on the determination of CBs in marine media. Fifty-eight laboratories from 16 countries participated in this exercise, which involved the determination of 10 CBs in a standard solution, a cleaned-up seal blubber extract, and a cleaned-up marine sediment extract. Suggestions were given for instrument optimization. Standard errors of 1.16-1.17 for the standard solution, 1.20-1.33 for the seal blubber extract, and 1.31-1.56 for the sediment extract were obtained for CBs 52, 101, 118, 138, 153, and 180 by all laboratories with the exception of the laboratories giving consistently outlying results. The results for CBs 28, 31, 105, and 156 showed larger standard deviations. The 2 major difficulties for participants in this exercise were correct preparation of a calibration solution and chromatographic separation. The results of the sediment analysis showed a complete lack of agreement. It is recommended that, prior to the organization of the third part of this study, participants should install gas chromatographic columns with minimum lengths of 50 m and maximum internal diameters of 0.25 mm and should prepare calibration solutions from solids of known purity.

Adipose Tissue↗
PubMedDate not supplied

Determination of chlorobiphenyls in seal blubber, marine sediment, and fish: interlaboratory study.

Between 1988 and 1994, the International Council for the Exploration of the Sea, the Intergovernmental Oceanographic Commission, and the Oslo and Paris Commissions organized a stepwise interlaboratory study for determination of chlorobiphenyls (CBs) in marine media. The final parts of this study, in which 53 laboratories from 14 countries participated, focused on long-term precision, cleanup, and extraction. Calibration was controlled continuously by analysis of 10 CBs in an unknown solution. Participants were requested to analyze 3 CBs in a certified reference material fish oil (6 times); 10 CBs in cleaned and uncleaned marine sediment and seal blubber extracts; and 10 CBs in seal blubber oil, dried marine sediment, and wet, lean fish muscle tissue. The long-term precision study showed that, compared with earlier exercises in which only duplicate analyses were required, repeatability increased about 1.5-fold compared with reproducibility. The mean standard error for reproducibility of determination of 10 CBs in standard solutions improved from 1.22 to 1.15. The standard error improved from 1.36 to 1.25 (without CBs 28 and 31) for seal blubber oil and from 1.36 to 1.22 for dried marine sediment. In seal blubber oil and dried marine sediment, the major CBs 118, 138, 153, and 180 can now be determined by the group of participating laboratories with a reproducibility of 1.5 (about 50%). No significant differences were found between results for cleaned-up and uncleaned extracts. No acceptable results could be obtained for determination of CBs in lean fish muscle tissue. Biplots of principal component analyses are extremely helpful in evaluating the data generated by this type of study.

Adipose Tissue↗