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Biomedical subjects

J Zingraff

Publications and source records attributed to J Zingraff.

At least 127 records · Page 7Linked to original sources
PubMed1977

The response of heart rate to isoproterenol in hemodialyzed patients before and after parathyroidectomy.

The response of the heart rate to intravenous isoproterenol was studied in seven chronic hemodialysis patients with severe hyperparathyroidism, before and after subtotal parathyroidectomy (PTX). Before PTX, significantly higher doses of isoproterenol were needed to achieve a standardized increase in heart rate when compared with the doses needed following PTX. A similar difference was observed before and after removal of a parathyroid adenoma in an additional nonuremic patient with primary hyperparathyroidism. This decreased cardiac responsiveness to a beta-adrenergic stimulus seemed to be related to the hyperparathyroid state.

Adenoma↗
PubMed1976

Effects of haemodialysis on fractional intestinal absorption of calcium in uraemia.

Fractional intestinal absorption of calcium was measured in 41 haemodialysed patients 4 hours after an oral dose of 47 Ca. Fractional intestinal calcium absorption was 40.3 +/- 1.9% (SEM) when measured 10 to 12 hours after a haemodialysis session (dialysate calcium concentration: 1.75 mmol/litre). This value was significantly lower (p less than 0.001) than that in 26 healthy controls (56.8 +/- 1.8%) and higher (p less than 0.05) than that of 35 patients with chronic renal failure treated conservatively (34.5 +/- 2.1%). In 17 patients, fractional intestinal calcium absorption was measured just before and just after a dialysis session. Pre-dialysis fractional intestinal calcium absorption (33.7 +/- 3.0%) was not significantly different from fractional intestinal calcium absorption in uraemic patients treated conservatively, while after dialysis fractional intestinal calcium absorption had increased significantly to 42.0 +/- 2.6% (p less than 0.001). It is suggested that the transient increase in fractional intestinal calcium absorption observed after dialysis could be related to dialysis induced volume depletion rather than to a vitamin D-dependent mechanism.

Calcium↗
PubMed1976

Measles virus and Guillain-Barré syndrome during long-term hemodialysis.

In a black man, recently receiving long-term hemodialysis, a severe, rapidly progressive polyradiculoneuritis (Guillain-Barre syndrome) developed. Routine virologic study revealed a high antimeasles virus antibody titer (1:1280 by hemagglutination-inhibition) which progressively decreased. There was no clinical evidence of measles. Discussed here is the possible relationship between the Guillain-Barre syndrome and clinically inapparent measles associated with and perhaps modified by the uremic state.

Adult↗
PubMed1976

Anti-beta adrenoreceptor blockade activity of plasma ultrafiltrate in two uraemic patients: effect of parathyroidectomy.

A possible interaction between d-1 propranolol and hyperparathyroid plasma ultrafiltrate on guinea pig auricles has been studied in "in vitro" experiments. Plasma ultrafiltrates have been samples in two patients on chronci haemodialysis before (pre-PTx) and after (post-PTx) parathyroidectomy. A significant inhibition of propranolol depressant activity on cardiac contractile strength has been observed in the presence of pre-PTx plasma ultrafiltrates. On the contrary, no such inhibition was noted in the presence of post-PTx plasma ultrafiltrates.

Animals↗
PubMed1975

[Accidental lithium poisoning in a patient with chronic hemodialysis].

The authors report a case of acute lithium poisoning, of double interest by virtue of its accidental origin and the fact that the patient suffered from chronic uraemia treated by intermittent haemodialysis, without residual diuresis. Neurological involvement consisted of a succession of dysarthria, behaviour disturbance, extra-pyramidal hypertonia and finally coma with respiratory difficulties. A favourable outcome was obtained by daily haemodialysis which made possible the elimination of almost all the lithium introduced into the body.

Gastrointestinal Diseases↗
PubMed1975

[A correlation between histocompatibility antigens HL-A 1 and 8 and an improved defense in the chronic uremic patient against hepatitis B virus].

Histocompatibility antigens have been studied in 328 uraemic patients treated by chronic haemodialysis, of whom 201 were contaminated by hepatitis-B virus associated antigen (HBs Ag). The frequency of the phenotypes HL-A 1 (36.2%), HL-A 8 (29.8%) and the HL-A 1,8 (23.4%) was significantly higher in the group of 47 patients who were able to eliminate HBs Ag after a transient antigenemia, than in the group of 154 patients who became chronic carriers of this antigen (P less than 0.01 for HL-A 1,8 association). These frequencies were also higher than the corresponding ones in the normal French population (P less than 0.01 for HL-A 8; P less than 0.001 for HL-A 1,8 association). In contrast, the HL-A frequencies observed in the group of patients with persistent antigenemia were not different from those observed in healthy controls. In conclusion, the presence of HL-A 1,8 phenotype seems to be correlated, in uraemic haemodialyzed patients, with a better immunological response against hepatitis B virus and hence, with the ability to elminate HBs Ag.

Antigens, Viral↗