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Biomedical subjects

J Zimmerman

Publications and source records attributed to J Zimmerman.

At least 145 records · Page 8Linked to original sources
PubMed1982

Four new proteins of the eumelanosome matrix of the chick pigment epithelium.

A new procedure is presented for the isolation of electron microscopically clean melanosomes. The procedure provides melanosomes which have veen stripped of their membrane components so that only matrix elements are examined. Solubilization of these melanosomes is by 8 M urea-1% Triton X-100 treatment with reduction and alkylation. The proteins are examined on sodium dodecyl sulfate-polyacrylamide gels and on acid-urea polyacrylamide gels. Evidence is presented indicating the presence of four low-molecular-weight proteins which have not previously been reported. Data indicate that these proteins are the major components of the melanosome matrix, that they are not histones and that at least one of them is a glycoprotein.

Animals↗
PubMed1982

Genetic comparisons of eumelanosome ultrastructure.

We recently reported the existence of several new ultrastructural components of the eumelanosome matrix from developing chick pigment epithelium. The material used in the original study was obtained from a random sample of heterogeneous chicken. We have now extended this analysis to four genetically well-characterized chicken types: jungle fowl, blue, dominant white, and recessive wheaten. In these four genotypes there are specific ultrastructural alterations in the eumelanosome matrix. These alterations are different for each of the genotypes studied and are probably reflective of differences in the functional nature of the genes involved. The data thus provide evidence as to which genes are structural and which regulatory in action. Furthermore, since the material analyzed was all derived from pigmented pigment epithelium, it is clear that these melanosomes are affected by genes previously thought to leave them untouched. Finally, data are presented that these new ultrastructural elements are also found in a different class of animals, the C57BL/10 mouse.

Animals↗
PubMed1981

Vitamin D metabolite concentrations in vitamin D deficiency. Are calcitriol levels normal.

The levels of vitamin D metabolites were measured in three children with a decreased dietary intake of calcium and vitamin D and sun exposure. All three children had hypocalcemia, hypophosphatemia, and elevated alkaline phosphatase activities. Two children had rickets, aminoaciduria, and elevated immunoreactive parathyroid hormone (iPTH) concentrations. The concentrations of vitamins D2 and D3, 25-hydroxyvitamins D2 and D3 (25-OH-D2 and 25-OH-D3), and 24,25-dihydroxyvitamin D (24,25-[OH]2D) were reduced. Nonetheless, the levels of calcitriol (1,25-[OH]2D) were normal. The combination of hypocalcemia, hypophosphatemia, and increased iPTH concentrations should result in supranormal calcitriol concentrations. Moreover, the ratio of PTH to calcitriol is significantly higher than in normal subjects. Accordingly, in patients with vitamin D deficiency and "normal" calcitriol values, the synthesis of this compound may be reduced. The evaluation of vitamin D deficiency should include the measurement of all metabolites.

24,25-Dihydroxyvitamin D 3↗
PubMed1981

Observations on the structure of the eumelanosome matrix in melanosomes of the chick retinal pigment epithelium.

Eumelanosomes from the developing chick pigment epithelium have been isolated, solubilized, and the residue collected. Examination of this material in the electron microscope provides evidence for new structural entities in the eumelanosome and information on the organization of the melanosome. This evidence suggests that there are (1) 190-A fibers arranged in a zigzag fashion, surrounding 240-A-diameter electron-lucent spaces and (2) an internal gridwork enclosing 40-50-A diameter spaces. These two structures are probably alternately layered and "rolled-up".

Animals↗
PubMed1981

Envenoming by Cerastes viper - a report of two cases.

Two cases of envenoming by Cerastes vipera are described Both were in snake collectors who were accidentally bitten on the finger while handling the snake. In both cases, local signs included a haemorrhagic bulla with fang marks, swelling and tenderness. These signs were mild in one case and moderately severe in the other, necessitating fasciotomy. No systemic signs were observed. Some coagulation abnormalities were found in both cases. In one, prolonged bleeding from the wound and a shortened euglobulin lysis time may suggest activation of the fibrinolytic mechanism. In the other, prolongation of prothrombin time occurred with no haemorrhagic diathesis. Treatment included fasciotomy in one case and elevation of the affected part and antibiotics in the other. It appears that the clinical course of this snakebite is relatively benign.

Adolescent↗
PubMed1981

Civil commitment as a "street-level" bureaucracy: case-load, professionalization and administration.

This article applies street-level bureaucracy theories to "coping" patterns of behavior that developed in an involuntary commitment system. Daily procedures and routines of five Nebraska county boards of mental health and the attitudes of their members were studied. The results showed that the urban, high case-load, professionally-oriented board informally modified statutory procedures significantly to reduce face-to-face client contact, limit the scope of its decisions, and displace responsibility for the most ambiguous decisions to the treatment facility and board psychiatrist. Rural, low case-load, less professionally-specialized boards also modified the statutory procedures, but conducted the commitment process in a far more ambiguous, open-ended, and tense system with substantial face-to-face client contact. Both urban and rural boards had multifaceted role definitions; rural boards, however, had a more open-ended perception of their functions, and attempted more actively to modify antisocial behavior and redirect board subjects to sources of social counseling. Therefore, understanding street-level "coping" behavior in an actual commitment context is important to develop realistic changes in civil commitment systems and to preclude informal procedures that reduce a commitment system's effectiveness or undermine a proposed patient' s rights.

Administrative Personnel↗
PubMed1980

Acute lymphoblastic leukemia. Association with vasopressin-responsive diabetes insipidus.

A rare case of acute lymphoblastic leukemia presenting with vasopressin-responsive diabetes insipidus (DI) is reported. The patient presented with polydypsia and polyuria of 9 L/day. Findings from special investigations of the CNS, including brain scan, computerized tomographic scan, EEG, and lumbar puncture were within normal limits. The patient's condition improved substantially after receiving vasopressin injections and later chlorpropamide. The incidence and underlying mechanism of this rare complication of acute leukemia are reviewed, and the response of DI to chlorpropamide is discussed briefly. In this patient it is presumed that the DI was caused by leukemic infiltration of the supraopticohypophyseal tract, posterior pituitary, or hypothalamus.

Adult↗
PubMed1980

Characteristics of patients with chronic pain.

We describe the characteristics which patients with chronic pain ascribe to themselves and present some of the data we have gathered in the areas of demographics, economic and family problems, difficulty in rehabilitation, and the failure of treatment methods such as surgery and medications to provide relief. We compared the responses of men and women and found significant differences in sexual difficulties and pain relief from nerve blocks.

Adult↗
PubMed1980

Clindamycin unresponsive anaerobic osteomyelitis treated with oral metronidazole.

A diabetic patient with peripheral neuropathy and a foot ulcer developed osteomyelitis of the foot. Antibiotic therapy of the aerobes isolated from the ulcer resulted in no clinical improvement. Intravenous clindamycin therapy of the anaerobe isolated (Bacteroides fragilis) was associated with an incomplete and temporary response, but there was a dramatic response to oral metronidazole with healing of the ulcer and osteomyelitis. One year later there were no signs of recurrence.

Administration, Oral↗
PubMed1979

Are microcomputers appropriate for your practice?

The overly simplistic view of the process of automation widely presented to physicians needs to be counterbalanced. Computers are becoming cheaper, easier to program, and simpler to operate. However, the physician must be aware of the gap between personal computing and serious use of computers in his practice. To bridge this gap, the physician must analyze his needs to identify appropriate applications to automate, plan the implementation of these applications, and choose the necessary hardware and software resources. To do so it may be valuable for him to seek the help of an expert. Although the physician can certainly perform the necessary tasks, he should be aware that to perform them efficiently there are a number of aspects he should seriously consider.

Computers↗
PubMed1978

Understanding trustees' concerns promotes board development.

A hospital's CEO has a major responsibility to promote development of the board into an effective, competent, functioning body. To do so, he must understand the special problems, fears, and risks that trustees confront in the health care setting; allow and expect the board to fulfill its own role; and provide a supportive environment in which the board can function and develop.

Governing Board↗
PubMed1978

The acceptability of computer applications to group practices.

Of the 72 identified group practices in a midwest urban environment, 39 were found to use computers. The practices had been influenced strongly by vendors in their selection of an automated system or service, and had usually spent less than a work-month analyzing their needs and reviewing alternate ways in which those needs could be met. Ninety-seven percent of the practices had some financial applications and 64% had administrative applications, but only 2.5% had medical applications. For half the practices at least 2 months elapsed from the time the automated applications were put into operation until they were considered to be integrated into the office routine. Advantages experienced by at least a third of the practices using computers were that the work was done faster, information was more readily available, and costs were reduced. The most common disadvantage was inflexibility. Most (89%) of the practices believed that automation was preferable to their previous manual system.

Computers↗