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Biomedical subjects

J Zielinski

Publications and source records attributed to J Zielinski.

At least 55 records · Page 3Linked to original sources
PubMed1989

Attempts at measuring pulmonary arterial pressure by means of Doppler echocardiography in patients with chronic lung disease.

In 72 patients with severe chronic pulmonary or pulmonary vascular disease pulmonary arterial pressure was measured by means of right heart catheterization. Forty three patients had pulmonary hypertension, (32 +/- 11 mmHg) and 27 patients had normal pressure (14 +/- 3 mmHg). These patients were examined with continuous wave (CW) and pulsed wave (PW) Doppler echocardiography. The retrograde systolic tricuspid valve pressure gradient assessed with CW Doppler correlated with systolic pulmonary pressure (r = 0.92, p less than 0.001, SEE 7.7 mmHg) but was measurable in only 17 of the 70 patients. The flow velocity pattern in the right ventricular outflow tract could be recorded in 68 of the 70 patients. Acceleration time (AcT) from systolic flow onset to peak velocity correlated with mean pulmonary artery pressure (r = 0.72, p less than 0.001, SEE 8.3 mmHg). An AcT less than 90 msec had an 84% positive predictive value for pulmonary hypertension. Right ventricular isovolumic relaxation time could be measured in 59 of the 70 patients and correlated with systolic pulmonary artery pressure (r = 0.69, p less than 0.001, SEE 12.4 mmHg). No single Doppler method is at the same time easily applicable and accurate in prediction of pulmonary arterial pressure in patients with chronic lung diseases.

Cardiac Catheterization↗
PubMed1987

Sarcoidosis of the lung. Natural history and effects of treatment.

An analysis on the natural course of pulmonary sarcoidosis and effects of corticotherapy was carried out in 960 patients observed during 25 years (1959-1985). There were 434 males and 526 females in the studied group aged from 14 to 69 years, when entering the study. The time of follow-up ranged from 2 to 20 years. In 20% of subjects disease had an acute course, in the remaining 80% the process was symptomless, often of chronic nature. Majority of patients presented with stage I or stage II of the disease (respectively 48.2% and 48.6%). Histological confirmation was obtained in 70% of subjects. Spontaneous remission or improvement was observed in 62.2%. Remission or improvement following treatment was seen in another 18.7% (a beneficial effect being observed in 84.1% of treated patients). Altogether remission or improvement, spontaneous or after treatment, was seen in 80.9% of studied group. In the remaining 19.1%, 2.8% of whom were treated and 16.3% not treated, a progression of the pulmonary changes was observed-the disease evolved into chronic stage. In acute pulmonary sarcoidosis the evolution of the disease was more favorable. Remission or improvement, spontaneous or after treatment, was observed in 89.3% of patients, versus 76.3% of patients with symptomless course of the disease. Recurrence of the disease was observed in 21 cases. It was seen only in treated patients shortly after completion of treatment.

Adolescent↗
PubMed1985

Synthesis and evaluation of potential radioligands for the progesterone receptor.

Several steroidal analogues were synthesized as potential gamma-emitting radioligands for the progesterone receptor. Each of these compounds was tested as an inhibitor of the specific binding of [3H]-17 alpha,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione (R5020) to the progesterone receptor in rabbit uterine cytosol. R5020 is a well-known progestin with high affinity for the receptor. Of the compounds synthesized, aromatic N-substituted C-17 steroidal carboxamides inhibited the binding only poorly. Three compounds, 16 alpha-iodo-4-estren-17 beta-ol-3-one, 17 alpha-[2(E)-iodovinyl]-4-estren-17 beta-ol-3-one, and 17 alpha-[2(Z)-iodovinyl]-4-estren-17 beta-ol-3-one were excellent competitors, each having a Ki less than or equal to that of the natural progestin, progesterone. Since similar iodinated analogues of estrogens have been shown to be extremely stable both in vivo and in vitro, these compounds are potentially useful ligands for the progesterone receptor.

Animals↗
PubMed1985

[Value of a brief ergometric test in the functional evaluation of chronic bronchopneumopathy].

The purpose of this work was to study the usefulness of short muscular exercise as part of standard respiratory function testing. A group of 19 patients with chronic bronchitis performed moderate load exercise (30 to 60 watts) on a cycle ergometer for 10 mn. Blood gases and acid-base balance were measured at rest, at the 2nd and the 10th mn of pedaling. In spite of highly significant relationships between resting values (blood gases, spirometry) and exercise data (blood gases), the scattering of the results precludes predicting the latter from the former. In contrast, the comparison between each of the two exercise results (2nd and 10th mn) shows not only a highly significant correlation but also a standard deviation to the regression lines which is objectively diminished. Thus, muscular exercise seems to give specific information that could be a useful component of respiratory function testing. Further, blood gas results obtained at the 2nd mn of muscular exercise suffice, thus obviating the need for a longer exercise programme that might be badly tolerated by patients.

Acid-Base Equilibrium↗
PubMed1984

Prediction of pulmonary hypertension from postural changes of pulmonary transfer factor.

The differences between lung transfer factor values measured in supine and standing positions were correlated with pulmonary artery pressures in 61 patients with chronic obstructive lung disease and in 34 patients with recurrent pulmonary embolism. No significant correlation was found. The postural change of transfer factor cannot be used as a noninvasive indicator of pulmonary artery pressure in these diseases.

Blood Pressure↗
PubMed1984

Effects of oxygen therapy on pulmonary arterial hypertension in chronic obstructive lung disease.

In patients suffering from chronic obstructive lung disease pulmonary arterial hypertension is mainly due to anatomical lesions. For this reason it does not regress following acute administration of oxygen, unlike functional pulmonary arterial hypertension due to vasoconstriction, which superimposes itself on the anatomical lesions during exacerbations of respiratory insufficiency. At present there is convincing proof that protracted treatment with oxygen is able to reduce pulmonary arterial hypertension sustained by anatomical alterations. Two recent studies, one carried out in the U.S. (duration of follow-up: 6 months), the other in Great Britain (duration of follow-up: 5 years), have reached this conclusion. The effects of oxygen on pulmonary arterial hypertension are directly proportional to the number of hours in which oxygen is administered daily; in any case this number should not be below 15 hours/day. The reasons for which treatment with oxygen is not able to arrest the evolution of pulmonary arterial hypertension in some patients and the role of the reduction in blood viscosity due to oxygen therapy remain to be clarified.

Blood Pressure↗
PubMed1979

[Myorenal (crush) syndrome from the nephrologic and urologic viewpoint].

The following measures contribute to the decrease of lethality in the crush-syndrome: 1. possibly rapid rescue measures with simultaneous infusion therapy, if technical difficulties delay them, 2. beginning of the infusions on the spot, particularly solutions of sodium bicarbonate, concentrated glucose solutions, remedies of blood substitute, but no blood transfusions, 3. transport into a hospital with possibilities of dialysis, 4. early fasciotomy or amputation, 5. early haemodialysis, 6. adequate antibiotics, 7. sufficient supply of calories and protein, perhaps infusions of amino acids.

Crush Syndrome↗
PubMed1978

[New knowledge in the treatment of post-traumatic strictures in the posterior urethra].

At present on principle 3 methods are taken into consideration for the treatment of the posttraumatic strictures of the urethra: 1. the skin filling methods, 2. the methods used by us personally, based on bursting the stricture and using the abundantly mobilised distally flapped distal stump of the urethra and 3. the urethrotomy under vision with sharp cut. Whether one method may claim exclusiveness, we shall know probably already in the next years.

Dilatation↗