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Biomedical subjects

J Zerner

Publications and source records attributed to J Zerner.

16 recordsLinked to original sources
PubMed1981

Intrauterine contraceptive device failures in renal transplant patients.

Concern is voiced regarding sexually active renal transplant patients and their use of the IUD for contraception. Two patients of this type conceived while receiving immunosuppressive therapy. The possible mechanisms of the IUD in preventing conception are mentioned. Immunosuppression may significantly alter these actions, thus allowing fertilization and implantation to occur. Alternate means of contraception are suggested in place of IUDs for these patients.

Adolescent↗
PubMed1980

A clinicopathologic study of vagina and cervix in DES-exposed progeny.

In this survey of 210 women with a history and/or gross changes of the cervix and vagina characteristic of DES exposure, changes related to vaginal adenosis were correlated with age. The mean age of women with columnar epithelium alone was 18.5 +/- 3.2 years, columnar epithelium with squamous metaplasia was 20.2 +/- 3.4 years, and squamous metaplasia alone was 23.0 +/- 2.7 years. These findings suggest that involution of vaginal adenosis occurs with increasing age. Involution of glands in the superficial stroma in most cases occurred concurrently with that of surface columnar epithelium. However, those deeply seated and complex glands in the stroma might lag in the metaplastic process and might persist. The pitfalls of misinterpretation of squamous cell changes in histologic samples were discussed. The lack of correlation between the colposcopic findings of mosaicism and/or punctuation and squamous cell neoplasia was confirmed in this study.

Adolescent↗
PubMedDate not supplied

Basal cell carcinoma of the vulva.

Basal cell carcinoma was found in eight of 61 cases of vulvar malignancy occurring over a 20-year period. This incidence of basal cell carcinoma was 13.1%, higher than the expected 2%-5% reported previously in the literature. Symptoms of a mass, usually discharge, pruritus or bleeding, were commonly ignored for long periods of time by the elderly patient. The specific location and size were difficult to ascertain from hospital records. Therapy is always surgical with wide local excision recommended. Local recurrence will be noted in 10%-20%, as vulvar basal cell carcinoma is a multicentric lesion and, therefore, long-term follow-up, as with any malignancy, is mandatory. Adequate identification and reporting may well show that this lesion is more common than has been previously thought.

Adult↗