Biomedical subjects

J Zentner

Publications and source records attributed to J Zentner.

129 records · Page 8Linked to original sources

PubMedDate not supplied

Effect of propranolol on portal vein hemodynamics in patients with liver cirrhosis: assessment by duplex sonography.

Portal vein hemodynamics of 11 patients with cirrhosis confirmed by liver biopsy and of 5 healthy volunteers were studied by duplex sonography during oral treatment with 80 mg propranolol. One hour after oral administration of 80 mg propranolol, portal blood flow measured by duplex sonography was reduced by 35.3% in cirrhotic patients and by 28.1% in healthy volunteers (n.s.). Portal blood flow reduction was maximal three hours after administration of propranolol (46.9%). During the follow up of cirrhotic patients to whom 80 mg propranolol was administered daily, the reduction of portal blood flow persisted and was 45.0% after 1 week and 37.0% after 4 weeks. Each cirrhotic patient responded with a reduction in portal blood flow. Duplex sonography was found to be an accurate follow-up method of cirrhotic patients under therapy with propranolol.

Administration, Oral↗

PubMedDate not supplied

Results of early surgery in poor-grade aneurysm patients.

METHODS: During a 4-year-period (1991-1994) a total of 85 poor-grade [Hunt and Hess (H&H) IV and V] patients were treated for aneurysmal subarachnoid hemorrhage. Patients who were admitted in poor grades but improved after initial treatment were excluded from this study. RESULTS: Overall mortality was 46% (N = 39). In particular, 29% (18 out of 63) of surgically treated patients had died as opposed to 95% (21 out of 22) of conservatively treated patients. Early surgery provided favourable (Glasgow-Outcome-Scores (GOS) 4-5) results in 52% of H&H grade IV patients but only in 22% of grade V patients. In particular, approximately one fourth of grade IV patients had a good outcome and 30% were only moderately disabled. Intracranial pressure (ICP) below 20 mmHg proved to be a favourable prognostic sign. CONCLUSIONS: It is concluded that, in consideration of the management mortality encountered with delayed surgery, H&H grade IV patients benefit from early surgical treatment while the prognosis of grade V patients still remains unfavourable.

Adult↗

PubMedDate not supplied

Diagnostic significance of MEP elicited by electrical and magnetoelectric stimulation in acute/subacute supratentorial lesions.

Motor evoked potentials (MEP) elicited by transcranial electrical and magnetoelectric stimulation were examined prospectively in a total of 122 patients with supratentorial tumorous and nontumorous lesions in an acute/subacute neurosurgical setting. All patients had a hemiparesis contralateral to the lesion. It was the aim of our study to define the diagnostic significance of MEP with respect to superficial and deep localization of the lesions. To achieve this goal, MEP findings were correlated with the clinical motor status defining two categories: correct with pathological MEP, and false-negative with normal MEP. On the whole, we found correct results in 108 of 122 patients (88.5%) with electrical stimulation, and in 67 of 75 patients (89.3%) with magnetoelectric stimulation. There were false-negative results in 4 (11.5%) and 8 (10.7%) cases, respectively. In particular, with electrical stimulation 14 of 65 (21.5%), and with magnetoelectric stimulation 8 of 43 (18.6%) superficial lesions were missed, whereas deep lesions were correctly assessed in every case by either stimulation technique. In conclusion, the diagnostic significance of MEP for assessment of superficial supratentorial lesions is limited with the methods applied in this study. Whether more refined techniques may provide different results in a similar setting remains to be proved.

Adolescent↗