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Biomedical subjects

J Zander

Publications and source records attributed to J Zander.

At least 73 records · Page 4Linked to original sources
PubMed1983

Prognostic criteria in patients with endometrial cancer.

Between 1970 and 1977 216 patients were operated on for adenocarcinoma of the endometrium at the I. Universitäts-Frauenklinik, Munich. The 5-year-survival rate for stage Ia was 79.7%, for stage Ib 86.4%, and for stage II 66.7%. Reliable prognostic criteria were tumor grading, lymphatic invasion, and myometrial tumor invasion. The 5-year-survival rate in patients with grade 1 carcinoma was 88.9% in patients with grade 3 carcinoma only 33.3% Patients with adenoacanthoma had a 5-year-survival rate of 73.3%, those with an adenosquamous carcinoma a 5-year-survival rate of 50%. Patients with no evidence of lymphatic invasion showed a 5-year-survival rate of 84.9%, those with proven invasion of lymphatic vessels a survival rate of 52.9%. In patients with tumor infiltrating one third of the myometrium the 5-year-survival rate was 90%. In patients with tumor infiltrating two thirds of the myometrium the 5-year-survival rate was 66.7%, and with infiltration of the full thickness of myometrium it was 33.3%.

Adenocarcinoma↗
PubMed1983

[Morphological criteria in decreased patients who had undergone surgery for cervical cancer].

In 966 patients who had undergone surgery and who had been suffering from squamous cell carcinoma, tumour recurrence occurred in 16.8% of the cases. In almost 70% of these cases, recurrence was seen in the first two years following treatment. 15% of the patients died of the carcinoma. Compared with the patients who had stayed alive, post-mortem examination of the patients who had died of carcinoma revealed in 65.5% of the patients an immature squamous cell carcinoma, in 37.7% a dissociated tumour growth, in 21.7% penetration of the tumour into the lymph vessels, and in 62.1% penetration into the blood vessels. Macrometastases in the area of the regional lymphatic nodes were seen in 45.2%. In the surviving patients, the percentage of immature carcinomas was 47.4%, whereas dissociated tumour growth was seen in 18.7% and penetration into the lymph or blood vessels in 5.8 and 14.1% of the cases, respectively. Macrometastases in the area of the regional lymphatic nodes were seen in 11.8% of the cases. In woman patients with an early recurrence of tumour, or in women who had died of the carcinoma, mostly immature carcinomas, tumour penetration into vessels, and macrometastases in regional lymphatic nodes were observed.

Carcinoma, Squamous Cell↗
PubMed1983

[Hysterectomy for septicemia following caesarean section].

From 1971 to 1980 20 patients at the first department of women of the university of Munich required a puerperal hysterectomy because of septicemia following caesarean section. During the same time a total of 2,726 caesarean sections were performed. 14 of the 20 women requiring hysterectomy had the caesarean section in the first department for women. Six women were referred with septicemia following caesarean section in another hospital. The causative relationship between caesarean section and septicemia was reviewed leading to the indication for hysterectomy. The indications for the caesarean section, risk factors for increased puerperal infection, the postoperative course, the indication for hysterectomy, the findings at operation the findings in the operative specimen and the course following hysterectomy were reviewed. Risk factors promoting an ascending infection postpartum were the type of labor, frequent vaginal examinations, previous attempts at vaginal delivery, and internal fetal monitoring by a scalp electrode. The recognition of incipient septicemia include severe pain in the abdomen and a subjective feeling of severe illness in the patient. The white blood count is increased, the body temperature is high and beginning respiratory insufficiency points to the severity of the illness. In these cases a repeat laparotomy with hysterectomy to eliminate the focus of infection is the treatment of choice for the septicemia. 19 of the patients who required hysterectomy for septicemia following caesarean section were discharged home after a mean hospital stay of 36 days. One of the patients died 41 days following caesarean section and 20 days following hysterectomy because of septicemia resistant to treatment.

Adnexa Uteri↗
PubMed1982

[The prognostic importance of the stage in patients operated for carcinoma of the endometrium (author's transl)].

The operative specimens of 216 patients who underwent operation for adenocarcinoma of the endometrium stage I and stage II were thoroughly examined. It was found that measuring the maximal depth of infiltration of the carcinoma in relation to the thickness of the uterine wall and other morphological criteria of the tumours such as tumour grading, and carcinomatous lymphangiosis have greater prognostic value than clinical staging and the length of the uterine cavity to the sound. In contradistinction to other observations we found that patients with a short length of the uterus had more often recurrences and distant metastases than patients with a long uterine length to the sound.

Adenocarcinoma↗
PubMed1982

[Effects of tramadol on haemodynamics and blood gases in the early postoperative period].

A variety of opioids is available for treatment of acute pain. Sometimes administration is limited due to typical side effects such as respiratory depression or pressure increase in the pulmonary circulation. Tramadol, a synthetic opioid, was investigated in a dosage of 1.5 mg/kg body weight i.v. with regard to changes in haemodynamic parameters and in blood gases. The haemodynamic parameters generally remained stable; all changes were statistically non significant. There were no signs of respiratory depression. The risk of pain therapy with opioids seems to be reduced further by the introduction of this agent.

Adolescent↗
PubMed1981

[Gynaecological problems in women patients on dialysis treatment and in women following renal transplants (author's transl)].

Women patients on permanent dialysis treatment or after transplants display on the whole an increased rate of malignomas; however, it has so far not been possible to assess the relevant incidence in a uniform manner. Hence, regular gynaecological examination should be the rule in order to detect and treat carcinoma risk changes in the genital region. Within the framework of a special gynaecological consultation for renal patients we found in 81 women patients under dialysis treatment one patient with carcinoma of the cervix and one patient with corpus carcinoma. In two cases a cystic ovarial tumour was operated on. To date the 21 patients who had undergone renal transplant surgery did not show any malignant change in the genital region. Choice of contraceptives should rule out the intrauterine device because of the increased hazard of infection under immunosuppressive treatment. Ovulation inhibitors with higher oestrogen doses represent an additional hypertensive risk. Treatment with low-dosage gestagens should produce the lowest rate of side effects.

Adolescent↗
PubMed1981

[Formation of metastases in the ovaries in operated squamous cell carcinoma of the cervix uteri (author's transl)].

Formation of metastases in the ovaries in carcinoma of the uterine cervix is a rare occurrence. 749 ovaries were subjected to histological examination in 980 operated patients with squamous cell carcinoma of the cervix. A metastatic carcinoma in the ovary was identified in four patients (0.5%). In three patients, a tumour had formed simultaneously in the corpus uteri. This might point to a metastatic spread of the tumour in the same manner as in carcinoma of the endometrium. In view of the low incidence of metastases in the ovaries adnexectomy would not be generally justified.

Carcinoma, Squamous Cell↗
PubMed1981

Borderline personality disorder: interrater reliability of the diagnostic interview for borderlines.

Three interviewers, working in pairs and using the Diagnostic Interview for Borderlines (DIB), interviewed three samples of 10 adult psychiatric inpatients. The two members of each interviewer pair alternated in the role of interviewer. Each member of the interviewer pairs completed the interview schedule and scored the protocol according to the instructions provided by the authors of the DIB. Interrater reliability was determined for each interviewer pair using the Kappa statistic. Reliability values were at about the level reported recently by Spitzer, Forman, and Nee (1979) for DSM-III axis I diagnoses in general. Additional statistical analyses were performed to determine whether there were patient sex differences on DIB scores, whether the two male interviewers differed from the female interviewer in their ratings of male or female patients, and whether experience differences among the three interviewers were reflected in their rating of patients. Among the latter analyses, the only significant finding was that in the interviewer pair consisting of a very experienced male psychiatrist and a male first year psychology graduate student, the former rated male patients as less borderline than did the latter. No other difference was found among raters, or between sex of patient and interviewer sex or amount of clinical experience. It was concluded that the DIB is sufficiently reliable for use in clinical research.

Adolescent↗