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Biomedical subjects

J Yip

Publications and source records attributed to J Yip.

26 records · Page 2Linked to original sources
PubMed1993

Treatment of closed comedones--comparisons of fulguration with topical tretinoin and electrocautery with fulguration.

Two consecutive studies were performed with the aim of clearly defining the optimal physical treatment for closed comedones. The first 10 patients with clinically significant numbers of facial comedones were treated with fulguration under EMLA anaesthesia on one side of the face and topical tretinoin on the opposite side. At the end of the study fulguration was shown to be significantly (p = 0.005) superior to topical tretinoin. A direct comparison of light electrocautery using EMLA anaesthetic with fulguration without anaesthesia was then performed on 12 patients. The comedones were subdivided by size into those that were approximately 1 mm or less in diameter and those of greater dimensions. In the treatment of larger comedones electrocautery was shown to be significantly superior to fulguration (p = 0.025), but there was no significant difference in the efficacy of the treatments for the smaller lesions.

Acne Vulgaris↗
PubMed1992

Hormonally exacerbated hereditary angioedema.

Hereditary angioedema is a rare disorder which is associated with an inherited deficiency of the inhibitor of the activated first component of complement. Genetic transmission occurs in an autosomal dominant manner. Affected patients are heterozygotes, and their deficiency is incomplete, many of them having up to 20% of the normal amount of the inhibitor. We describe two cases of C1 esterase inhibitor deficiency occurring in a mother and daughter in whom the symptoms appeared to be related to the menstrual cycle or the taking of the oral contraceptive pill. Although both features have been mentioned in the literature, to the best of our knowledge premenstrual exacerbations have not been documented previously. We examined the likely basis of hormonally exacerbated hereditary angioedema.

Adolescent↗
PubMed1991

Caffeine as a metabolic probe: validation of its use for acetylator phenotyping.

The use of two caffeine metabolite ratios for acetylator phenotyping was validated by demonstrating concordance with two sulfamethazine tests in 178 unrelated healthy subjects. The caffeine metabolites used for this purpose were 5-acetylamino-6-amino-3-methyluracil (AAMU), 1-methylxanthine (1X), and 1-methylurate (1U). The ratio AAMU/(AAMU + 1X + 1U), referred to as molar ratio or N-acetyltransferase, was compared with the ratio AAMU/1X. The results indicated that, for screening purposes, the acetylator phenotype can be determined by analysis of a 6-hour urine sample after a cup of coffee or strong tea or a can of caffeine-containing soft drink. The ratio AAMU/1X is the ratio of choice for the study of subjects in whom variability of xanthine oxidase can be neglected; use of the ratio AAMU/(AAMU + 1X + 1U) appears appropriate for special purposes. Gender, ethnic origin, habitual or moderate consumption of coffee, tea, soft drinks, or ethanol, or cigarette smoking have little if any effect on the caffeine tests for acetylator phenotyping.

Acetylation↗
PubMed1981

Cytologic screening for cancer of the uterine cervix. "The debate of 1980s".

A review of 2971 cytology specimens taken during 4725 college student clinic visits yielded only 14 abnormal Pap smears suggestive of mild to moderate dysplasia. Eight of these patients had colposcopic evaluation and seven had biopsy-proven dysplasia. These findings in a low-risk population along with the recent American Cancer Society's guidelines are discussed.

Adolescent↗
PubMed1977

A musical conservation problem.

7 piano pupils (8 to 16 yr.) judged which of two printed musical passages required more playing time. It was hypothesized that younger pupils would not conserve the indicated rhythm. Results support the hypothesis, showing that these children based their judgments on spatial/perceptual characteristics rather than on implied quantitative dimensions of the stimuli. Implications for developing non-traditional teaching methods are discussed.

Adolescent↗