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Biomedical subjects

J Yata

Publications and source records attributed to J Yata.

At least 163 records · Page 9Linked to original sources
PubMed1978

Nonspecific activation of complement by leukemic cells.

Non-specific activation of complement (NAC) on cell membranes via the alternative pathway was studied by using leukemic cells and cells from a generalized reticulohistiocytosis. The cells were treated with normal human serum in veronal-buffered saline containing ethyleneglycoltetraacetrate and MG++. Since human erythrocytes (HuE) are known to adhere to complement-reacted cell membranes in an immune adherence reaction, complement activation on the cell membrane was confirmed by the rosette formation of HuE which is due to the generation of C3b molecules on the cell membrane. Only cells from Schilling-type acute monocytic leukemias and cells from a generalized reticulohistiocytosis possessed NAC ability. All other leukemic cells tested, as well as normal hematopoietic and lymphoreticular cells, were NAC-negative. Furthermore, none of the mitogens tested generated NAC ability on normal peripheral blood lymphocytes.

Bone Marrow Cells↗
PubMed1978

Changes in T-cell subsets and their clinical significance in cancer patients.

The proportion of T cells that have receptors for IgG-Fc (Fc R+ T cells), the functioning of T cell helpers in immunoglobulin production and the blastogenic response of lymphocytes to PHA and Con A were measured in cancer patients. Increases in the percentage of IgG-Fc R+ T cells were observed in most patients; these were greater in patients with advanced tumours and fell within the normal range after complete surgical removal of the tumour. The functioning of T cell helpers in immunoglobulin production and response of lymphocytes to PHA were poor in those patients in whom IgG-Fc R+ T cell percentages were increased. The lymphocytes of such patients responded well to Con A. These changes in T-cell subsets appear to be related to the presence and progress of tumours.

Carcinoma↗
PubMed1978

Requirement of HLA compatibility between T- and B-cells in mitogen-induced in vitro immunoglobulin production.

The necessity for human leukocyte antigen (HLA) compatibility in T- and B-cells in the differentiation of B-cells into immunoglobulin-producing cells (Ig cells) was studied in cultured human lymphocytes stimulated with pokeweed mitogen. We found that, despite the histocompatibility antigen difference, allogeneic T-cells from healthy donors could help B-cells to differentiate into immunoglobulin-producing cells to almost the same degree as autologous T-cells. However, T-cells from an apparently healthy subject whose sister had died of severe combined immunodeficiency did not collaborate with HLA-incompatible allogeneic B-cells in vitro, although her T-cells collaborated with autologous B-cells as well as B-cells from a brother with identical HLA-A, -B and -D. This indicates that the mechanism which in normal cases overcomes HLA antigen incompatibility was defective in this case. It further indicates that one of the mechanisms necessary in B- and T-cell interaction requires HLA compatibility.

Antibody-Producing Cells↗