Search PubMed⌕ Search

Biomedical subjects

J Work

Publications and source records attributed to J Work.

45 records · Page 3Linked to original sources
PubMed1980

Studies on the natural history of the norepinephrine model of acute renal failure in the dog.

Studies on the natural history of the norepinephrine (NE) model of acute renal failure (ARF) in the dog. Group I (n = 6) was infused with NE into the renal artery (0.75 microgram/kg/min x 80 min) and glomerular filtration rate (GFR) determined sequentially. 21 days post-NE infusion (I) the GFR of the I kidneys (20 + or - (SE) 5ml/min) remained less (p less than 0.001) than the pre-I control value (44 plus or minus 2.9). Group II (n = 7) was treated in an identical fashion except that a contralateral nephrectomy (CN) was done on day 7 and the animals were prepared for micropuncture on day 16. In the animals with residual nephron function at CN, the GFR increased (p less than 0.02) from 26 plus or minus 6.4 ml/min on day 7 to 38 plus or minus 6.6 ml/min on day 14. Considerable interanimal heterogeneity of single nephron GFR (SNGFR) was demonstrated and morphologic studies revealed a very patchy lesion. Therefore, the model is reversible, heterogeneity of SNGFR is present, and the residual functioning nephrons have the capacity to undergo an increase in GFR after CN.

Acute Kidney Injury↗
PubMed1980

Charcoal hemoperfusion in the therapy for methsuximide and phenytoin overdose.

Two patients suffered overdoses of anticonvulsant drugs. The first patient took methsuximide and the second, phenytoin. Because of profound CNS depression, both patients underwent hemoperfusion with a cellulose-activated charcoal hemoperfusion column. The primary metabolite of methsuximide, N-desmethylmethsuximide, primarily was responsible for the CNS depression in the first patient. The clearance of N-desmethylmethsuximide by the charcoal column was high, and clinical improvement became apparent during the hemoperfusion period. The clearance of phenytoin, on the other hand, was much lower than that of N-desmethylmethsuximide, and there was no apparent clinical improvement in that patient's condition.

Adult↗
PubMedDate not supplied

Chronic catheter placement.

Since the 1997 publication of the Disease Outcomes Quality Initiative (DOQI) vascular access guidelines for cuffed, tunneled catheter placement, additional evidence supporting these recommendations has been published, including additional documentation supporting the right internal jugular vein as the preferred site for insertion. Placing the catheter tip in the right atrium rather than in the superior vena cava will provide adequate blood flow to support effective hemodialysis. The right atrial positioning of the catheter tip will also accommodate catheter tip retraction and decrease the likelihood of malfunction. Overwhelming evidence now supports the use of ultrasound guidance to assist cannulation of the internal jugular vein. This evidence is based on several studies documenting anatomical variations of the internal jugular vein. Ultrasound guidance has significantly decreased the incidence of serious complications of jugular vein cannulation. Finally, a specific technique of catheter placement with variations for catheter types is described.

Catheterization, Central Venous↗
PubMedDate not supplied

Tamm-Horsfall protein antibody in patients with end-stage kidney disease.

Circulating antibody to Tamm-Horstall protein (THP) was measured using a radioimmunoassay in forty-five patients on maintenance hemodialysis and compared to levels of antibody titers measured in sera from ten healthy controls. The etiology of the end-stage kidney disease in the patient population was polycystic kidney disease in thirteen, glomerulonephritis in fourteen, diabetic nephropathy in nine, interstial nephritis and chronic pyelonephritis in three each, multiple myeloma in two, and urinary tract obstruction in one. Four patients had significantly elevated titers of antibody to THP but shared no other unifying characteristics. The results also indicate that none of the groups studied had mean antibody titers significantly different from controls. Furthermore, no general trend was apparent between levels of antibody to THP and number of months on dialysis. Observations made during the study revealed that heparinized samples of blood had lower titers of antibody to THP than did non-heparinized samples from the same patient. This finding was repeated when other anti-coagulants, i.e., ethylenediaminetetraacetate (EDTA) and sodium citrate, were used. Titers returned toward normal when CaCl2 was added back to samples anticoagulated with EDTA and sodium citrate. This suggests that clotting factors, probably fibrinogen, interfered with the measurement of antibody titers. Therefore, only serum should be used in further investigations of THP antibody using this assay.

Adult↗