Search PubMed⌕ Search

Biomedical subjects

J Woods

Publications and source records attributed to J Woods.

At least 91 records · Page 5Linked to original sources
PubMed1981

Distribution of HLA class 1 antigens in normal human tissue and in mammary cancer.

With a monoclonal antibody which reacts with all HLA class 1 antigens it was found that these antigens are not uniformly distributed in all nucleated cells. Rather HLA class 1 antigens are restricted in their distribution to lymphoid cells, endothelial cells of small vessels, and certain epithelia including mammary duct cells. These antigens were not detected on hepatocytes, specialised cells of the central nervous system, or on the tumour cells of 8 out of 17 human mammary cancers. Given the hypothesis that T cells only respond to foreign antigens on cells which share a common major histocompatibility antigen, these results imply that the T cell responses to viral infections of hepatocytes--for example, hepatitis B virus and the CNS--for example, subacute sclerosing encephalitis, are mediated through an antigen system other than HLA class 1. The absence of HLA class 1 antigen on many mammary cancer cells may be of prognostic significance if T cell modulation of tumour growth is mediated through this class of antigens.

Adolescent↗
PubMed1980

Dermatoglyphic abnormalities in the fetal alcohol syndrome.

Dermatoglyphics of 19 male and 23 female patients with fetal alcohol syndrome were compared with those of matched controls. Both male and female patients differed in several of the dermatoglyphic characteristics from their sex-matched controls. The abnormalities of dermatoglyphics reported here constitute a valuable marker trait of the teratogenic effect of the alcohol on fetal development and provide additional diagnostic signs for the fetal alcohol syndrome.

Black People↗
PubMed1977

An unsuccessful attempt to treat hypertension with acupuncture.

The effectiveness of 5 sets of acupuncture loci in decreasing systemic blood pressure was compared with chlorthalidone and propranolol in patients with essential hypertension. No statistically significant acute or long-term changes in plasma catecholamines, renin activity, or blood pressure and pulse rate were observed as a result of acupuncture treatment. The decrease in blood pressure was significantly less than that observed with propranolol, but not significantly less than that produced by chlorthalidone. Because of the poor patient acceptance of acupuncture and in the absence of a beneficial response, we feel acupuncture as employed in this study is of limited value in the management of patients with essential hypertension.

Acupuncture Therapy↗
PubMed1977

Dermatoglyphics in Down's syndrome patients of different racial origins.

To investigate whether the phenotypic resemblance of Down's syndrome patients of different racial origins extended to include their dermatoglyphic characteristics, we made comparisons of dermal pattern frequencies on digits, palms, and hallucal areas of white, black and Japanese patients and matched controls. The results showed similarities in frequencies of digital whorls and ulnar loops in patients of all racial groups, of patterns in hallucal, thenar/I, second and third interdigital areas in white and black patients, and of hypothenar patterns and t" triradii in Japanese and black patients. The frequencies of the digital arches and remainder of the palmar configurations in patients of three racial groups showed significant, though often smaller, differences than those found in their controls.

Black or African American↗
PubMedDate not supplied

An in vivo and in vitro investigation into the effects of alpha- chlorohydrin on sperm motility and correlation with fertility in the Han Wistar rat.

Following a recommendation from the International Conference on Harmonisation, pharmaceutical companies are now monitoring possible drug effects on sperm motility in the rat during preclinical safety studies by assessing sperm motility (velocity). However, it is not known precisely how changes in sperm motility relate to fertility. Therefore, the effects of alpha-chlorohydrin on sperm motility were investigated and related to fertility both in vivo and in vitro. alpha-Chlorohydrin was given orally to male rats using a range of doses: 0, 5, 10, and 20 mg/kg for at least 5 consecutive days. Sperm were than assessed for motility using a standard scoring system (operators' observation of sperm) that graded degree of motility (i.e., 0 = i mmotile to 4 = very motile). The results showed a dose-related decrease in sperm motility. The sperm also appeared to move with a "jerky" action. Surprisingly, when this was correlated to fertility, none of the females mated with treated males became pregnant. A dose-related decrease in pregnancy would perhaps have been expected. There was no effect on sperm morphology, and testicular and epididymal pathology were only seen after doses of 20 mg/kg. When sperm from untreated rats were incubated with alpha-chlorohydrin in vitro at concentrations of 0, 0.5, 1.0, and 1.5 mM, sperm motility and motion were similarly affected as observed in vivo. However, the fertilization capacity (in vitro fertilization) of the treated sperm showed a concentration-related reduction in percentage fertilization, and there was also evidence of abnormal embryo development. These findings suggest that the present standard scoring system used in preclinical safety studies is not a comprehensive indicator of sperm function and/or fertility. A better understanding of sperm movement, therefore, is desirable so effects on sperm motility can be related to fertility.

Administration, Oral↗