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Biomedical subjects

J Woodruff

Publications and source records attributed to J Woodruff.

23 records · Page 2Linked to original sources
PubMed1975

Selection of the optimum surgical treatment of stage I melanoma by depth of microinvasion: Use of the combined microstage technique (Clark-Breslow).

The methods of histologic staging of primary Stage I melanoma and the relation to lymph node metastases and survival after surgery was evaluated in 151 patients with extremity melanoma only. Microstaging by depth of invasion showed a better prognostic correlation than by histologic typing (into superficial spreading, or nodular melanoma). A correlation existed between depth of invasion (Clark's levels) and incidence of nodal metastases at elective node dissection. This incidence was 5% at Level II, 4% at Level III, 25% at Level IV and 75% at Level V. The measured depth of invasion added prognostic insight to each Clark's level; the minimal invasion at which nodal metastases occurred was 0.6 mm for Level II, 0.9 mm for Level III, 1.5 mm for Level IV and over 4 mm for Level V. The 5 year disease-free survival after surgery was 100% for Clark Level II, 88% for Level III, 66% for Level VI and 15% for Level V. There was a direct relation between the measured depth of invasion and survival and mortality from disease at 5 years. Mortality from disease at 5 years could be directly equated with 10 times microinvasion in mm. Microstaging by direct measurement gave a better prognostic correlation than was found using Clark's levels for more deeply invading melanoma. At this time there is suggestive evidence that patients with certain higher risk lesions may do significantly better with wide excision and elective node dissection than with wide excision alone. These high risk lesions include Clark Level III to V, lesions measuring 0.9 mm or greater and all nodular melanomas.

Extremities↗
PubMed1968

Lymphocytes: circulation altered by trypsin.

Rat thoracic duct lymphocytes altered by trypsin in vitro do not circulate normally. At early intervals after transfusion of lymphocytes labeled with chromium-51 selective accumulation of radioactivity in the lymph nodes is abolished, while uptake in the spleen is not reduced. Later, the cells appear to "home" to lymph nodes and recirculate to the lymph.

Animals↗
PubMedDate not supplied

Multifocal extremity sarcoma: an uncommon and controversial entity.

BACKGROUND: The primary site of metastasis from extremity sarcomas is the lung. When patients with extremity sarcoma present with the disease in more than one site but not in the lung, the question of whether the disease is multifocal or metastatic is difficult to resolve. METHODS: We reviewed 1423 patients admitted with extremity sarcoma from 1982 through 1996. Patient demographics, primary site, other sites, local recurrence, distant metastasis, and survival were analyzed. Statistics were by Fischer exact test, chi 2, Kaplan-Meier method, and log-rank test where appropriate. RESULTS: Sixteen (1%) patients were identified with multifocal disease out of 1423 patients with extremity sarcoma. There was no difference in sex, age, size, grade, depth, and margins between multifocal and unifocal disease. In a mean follow-up time of 57 months, 50% had local recurrence of primary tumor, 80% had distant metastasis, and only 30% were alive at the time of the analysis. Whereas 21% of all patients with solitary disease develop lung metastasis, 63% of patients with apparent multifocal disease develop lung metastasis. The 5-year disease-specific survival of patients with multifocal disease was not different from that of all patients presenting with metastatic disease to lung. CONCLUSION: Whether multifocal disease exists or is merely a form of metastasis is unproven by this analysis, but the outcome is the same. Management algorithms should suggest treating patients with multifocal disease as if it is metastatic disease.

Disease-Free Survival↗
PubMedDate not supplied

Effects of cell mediated immunity in influenza virus infection in mice.

The role of cell mediated immune responses in recovery of mice from influenza virus infection was studied by immunosuppression and by adoptive immunization. Virus infections persisted longer and produced more severe lung lesions in animals injected with anti-thymocyte serum (ATS), and immunosuppressed animals failed to mount a serum HI antibody response. Mice injected with ATS after the 4th day of infection produced antibody in titers equivalent to those of control animals but still did not recover from infection as rapidly. Passive immunization with antibody late in infection did not facilitate clearance of virus from ATS injected animals. Adoptive transfer of spleen cells obtained from syngeneic animals sensitized intraperitoneally resulted in more rapid clearance of virus and less severe lung lesions in infected recipient animals. This effect was associated with a lower antibody response in recipient mice. Adoptive immunization was still effective after depletion of beta lymphocytes from the transferred cell population. These effects correlate with in vitro assays of the cytotoxic T cell response and antibody forming cell response of sensitized mice. From these observations we conclude that T lymphocytes may play a role in recovery from influenza virus infection by mechanisms other than helper effects.

Animals↗