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Biomedical subjects

J Wong

Publications and source records attributed to J Wong.

At least 739 records · Page 41Linked to original sources
PubMed1978

Unresectable malignant obstruction of the bile ducts.

Over a 13-year period we encountered 135 patients with malignant obstruction of the bile ducts, and in 81 of these patients only palliative surgery was possible. The type of operation was largely determined by the site and nature of the obstruction and the condition of the patient. The operative mortality of palliative operation was 37%. Relief of jaundice or pruritus was obtained in 68%, and this figure included a number of patients who died in the first 30 days. The majority of survivors lived for between three and four months after operation, although occasional patients have lived for more than one year.

Adenocarcinoma↗
PubMed1978

Buerger's disease--a review of 105 patients.

One hundred and five cases (101 males and four females) of Buerger's disease occurring in Hong Kong have been reviewed. In the foot the digits affected were predominantly the big, second and little toes, whereas in the hand the index and middle fingers were most commonly involved. There was no selective involvement of the left or right side in the upper or lower extremities. The majority of patients were operated on and had amputation, sympathectomy, or both procedures performed. Major lower limb amputation was carried out in 22.6% of patients with lower limb involvement. Reconstructive arterial surgery was possible in only four patients, and early failure of grafts in three patients resulted in major amputation.

Adolescent↗
PubMed1978

Colorectal carcinoma in Hong Kong.

The clinical and pathological features of colorectal carcinoma occurring in 470 Chinese patients in Hong Kong are reported. There was a preponderance of advanced stages of the disease in spite of the presence of a large number of well-differentiated lesions. Polyposis coli was the predisposing cause in 1% of our patients, and none of them had ulcerative colitis. The clinical features of our patients on presentation were generally similar to those exhibited by Caucasians. An abdominal mass was palpable in about half of patients with colonic lesions, and virtually all rectal cancers could be felt by rectal examination. Almost a quarter of our patients presented with complications. In 2% of our patients the initial diagnosis was acute appendictis. A high resection rate was achieved, but many radical resections turned out to be only palliative. Our operative mortality was 8.3%, although for social reasons, the "in-hospital" mortality was 19.2%. The corrected five-year survival rate was 42.7% when curative resection was attempted.

Adolescent↗
PubMed1978

Factors influencing morbidity and mortality in esophageal carcinoma.

In 1977, 152 patients with carcinoma of the esophagus were admitted under our care. The lesions were located from the hypopharynx to the cardiac portion of the stomach. A prospective study was conducted and the results (mortality and morbidity) were analyzed by computer. Resection was possible in 88 patients and a bypass procedure in 15. On exploration in five patients, the disease was found to be so extensive that no further operative procedures were undertaken. The mortality rate was high, hospital deaths being included in the operative mortality statistics. The best results were obtained by applying the Lewis-Tanner one-stage esophagectomy. When the disease was extensive, a bypass procedure using the Kirschner operation and postoperative irradiation was the method of choice. When the general condition of the patient was poor, the best procedure was a staged esophagectomy, with the reconstruction being undertaken at a later date.

Adult↗
PubMed1977

The incidence of unsuspected peripheral arterial disease amongst surgical patients in Hong Kong.

A survey of surgical in-patients in Hong Kong has shown that subclinical peripheral arterial disease caused by atherosclerosis and detected by palpation is not uncommon and is similar in incidence to that reported in European populations. However, only a small proportion of affected patients had any associated symptoms. Reduced or absent ankle and ulnar pulses occurred with the same frequency in our patients as in those in Europe. Cigarette smoking does not appear to be associated with symptomatic arterial disease in the local population in Hong Kong.

Adolescent↗
PubMed1977

Benign non-parasitic cysts of the liver: a review of 18 cases.

Benign non-parasitic cysts of the liver are a clinical and pathological curiosity except when they cause symptoms or are incorrectly diagnosed as metastases in patients with abdominal malignancy. It is difficult to make a correct diagnosis of benign liver cysts in spite of the armamentarium of modern diagnostic aids available, and on many occasions the diagnosis is made at laparotomy. This is a report of 18 patients with benign cysts of the liver, two of whom suffered complications which we believe have not previously been reported.

Adolescent↗
PubMed1977

Arterial problems seen in a teaching hospital in Hong Kong.

Over a 12-month period, 58 patients presented with arterial disease or other arterial problems to the University Surgical Unit, Queen Mary Hospital, Hong Kong. These patients accounted for only 0.6% of this Unit's annual admissions. In spite of the reported rarity of atherosclerotic arterial disease in this part of the world, this was the cause of the disease in nearly half of our patients. Abdominal aortic aneurysm was the single most common condition encountered. In at least one-third of patients with atheromatous disease of the aortoiliac segment, chronic peptic ulcers were demonstrated. It is concluded that peripheral arterial disease is rare, but atherosclerosis is the most common cause.

Arteries↗
PubMed1977

Leiomyosarcoma of the duodenum: a report of three cases.

Three cases of leiomyosarcoma of the duodenum are reported in this paper. The first patient demonstrated the development of a leiomyosarcoma from a leiomyoma, and also posed diagnostic problems as a Pólya gastrectomy had previously been performed. The second patient presented with acute pancreatitis--a hitherto unreported complication of this condition. The third patient showed that even though the primary tumour was unresectable, the patient remained well for more than a year after diagnosis.

Acute Disease↗
PubMed1977

Beta-Lactamase activity in strains of Bacteroides melaninogenicus and Bacteroides oralis.

beta-Lactamase from strains of Bacteroides melaninogenicus and Bacteroides oralis hydrolyzed penicillin more rapidly than ampicillin or carbenicillin. Cephalothin and a chromogenic cephalosporin (87/312) were also hydrolyzed by the enzyme. Activity was found only in beta-lactam-resistant strains, but there was considerable variation in activity among strains having the same minimal inhibitory concentrations of antibiotic. beta-Lactamase activity was cell bound and appeared to be tightly associated with the cell envelope since detergents were required to elute this activity.

Amidohydrolases↗
PubMed1977

A double trial of amoxycillin in the treatment of gonorrhoea.

A double blind comparison of two regimens of amoxycillin plus probenecid in the treatment of uncomplicated anogenital gonorrhoea is reported. Forty-three (86-0%) of 50 patients treated with 1 g amoxycillin plus 1 g probenecid and followed-up for 14 days were regarded as cured, and 51 (94-4%) of 54 patients treated with 3 g amoxycillin plus 1 g probenecid were regarded as cured. Fifty-nine per cent of 69 isolates of Neisseria gonorrhoeae were sensitive to amoxycillin (minimum inhibitory concentration less than or equal to 0-05 mg/ml). Although there was no statistical difference between the results of the two regimens it is concluded that the larger dose of amoxycillin plus probenecid is required where only 60% of gonococci are sensitive to amoxycillin.

Amoxicillin↗
PubMed1977

Hyperplasia of similar and dissimilar mucosa adjoining gastric mucosal wounds in the rat.

Deep mucosal wounds were produced within 1 mm of the squamo-columnar junction of the stomach of the rat, either on the squamous or on the glandular side, and the response of both the regenerating epithelium and of the adjoining, dissimilar epithelium was studied 24 hours to 12 weeks later. Squamous epithelium, both overlying previously injured squamous areas and adjoining previously injured glandular areas showed distinct hyperplasia that began on the 3rd day and was still present at 12 weeks. Glandular epithelium overlying previously injured glandular areas and adjoining previously injured squamous areas showed no hyperplasia but modulation of parietal and chief cells into mucus-secreting cells with increased mitosis. These changes appear more likely the effects of non-specific mitogenic agents than of reduced concentration of epithelial chalones.

Animals↗
PubMed1976

Complications of intravenous therapy.

A survey of 130 patients receiving intravenous therapy was undertaken. There were no instances of speticaemia over this period, despite a positive bacterial culture rate for cannulae of 48%. The incidence of phlebitis was 31%, and was associated with usual physicochemical factors. These included a cannulation time of greater than two days, an intravenous potassium supplement and antibiotics. Normal saline solutions given alone were associated with a lower incidence of phlebitis and continuous intravenous heparin administration may prolong the period of cannulation before phlebitis occurs. The institution of intravenous therapy teams should help to minimize the complications.

Anti-Bacterial Agents↗
PubMed1976

Liver scanning in patients with suspected metastatic malignant disease.

Liver scans of 72 patients with suspected malignant disease were evaluated to determine the accuracy of the investigation in detecting disease, including metastases and also its use to the referring surgeon. A comparison between the liver scan result and clinical and biochemical findings was also made. The liver scan had an overall accuracy of 83% in diagnosing metastases, compared with 64% for the serum alkaline phosphatase (SAP) level and was more useful clinically than the SAP level. Careful classification of the liver scan patterns allowed more consistent interpretation and improved the specificity of the diagnostic information obtained. Clinical assessment of liver and spleen size by abdominal palpation was unreliable and occasionally misleading.

Alkaline Phosphatase↗
PubMed1976

Use of rabbit antithymocyte globulin in cardiac transplantation. Relationship of serum clearance rates to clinical outcome.

Serum rabbit globulin (RG) clearance rates were determined in 30 consecutive cardiac transplant recipients by radioimmune assay of serum RG levels after completion of an initial postoperative course of rabbit anti-human antithymocyte globulin (RATG). Twenty patients, who exhibited rapid RG elimination rates (average half-life, 1.6 days), had a rejection onset time of 16.2 days rejection frequency of 3.9 episodes/100 patient days, and a 1-year survival rate of 59%, respectively, as compared with 28.3 days, 1.9 episodes/100 patient days, and 80%, respectively, for the 10 patients with more prolonged initial RG elimination rates (average half-life, 11.4 days); Nineteen patients received one or more repeat courses of RATG. In 16 of these a progressive increase in RG half-life during subsequent RATG administration could be demonstrated. A close correlation was observed between total RATG doses given in the initial course and peak serum levels of RG obtained (r = 0.82) and between onset of rejection and initial t1/2 RG (r = 0.69). This latter correlation was improved by the elimination of one of the 30 patients (r = 0.81) or by considering only those patients treated from a single RATG batch (r = 0.85; n = 15). No significant relationship was detected between any of the parameters assayed and (1) total RATG dose, or (2) rosette inhibition titers of RATG administered. Survival and rejection parameters of the first 30 patients receiving RATG were compared with the previous 20 receiving equine antithymocyte globulin; these 50 comprising the entire population in which rejection was confirmed by cardiac biopsy. Rejection onset was 20 versus 12 days, rejection frequency was 3.1 versus 5.0 episodes/100 patient days, and graft survival at 1 year was 66 versus 41% for the RATG-equine antithymocyte globulin-treated patients, respectively. From these data it was concluded that (1) RATG administration favorably affects transplantation outcome; (2) RATG half-life, as reflected by RG clearance rates, was the most important variable governing RATG effectiveness, (3) variation in rosette inhibition titers within RATG batches made in the same fashion from large rabbit pools were of minimal clinical importance; and (4) monitoring of serum RG levels provided a necessary and rational basis for effective modulation of immunosuppressive therapy.

Animals↗
PubMed1976

Comparative isolation of vaginal yeasts on selective and nonselective media.

The isolation of vaginal yeasts was compared on a selective medium, phosphomolybdic acid agar, and on starch agar, a nonselective differential medium used primarily to isolate Corynebacterium vaginale. The majority of the Candida albicans strains were isolated on starch agar, but the selective medium was required for isolating all yeasts from the greatest number specimens.

Agar↗
PubMed1976

Low-affinity interaction of ethanol with the fluorescent complex between horse liver alcohol dehydrogenase and auramine O.

Quenching of the fluorescence of the complex between horse liver alcohol dehydrogenase (alcohol:NAD+ oxidoreductase (EC 1.1.1.1) and auramine O complex is inconsistent with a simple competitive displacement of auramine O by ethanol. Instead, the action of ethanol requires an explanation in terms of a solvent effect, or the formation of an enzyme-auramine O-ethanol ternary complex. The latter complex would have to be the low-affinity variety similar to the enzyme-NADH-ethanol ternary complex encountered in the kinetic system.

Alcohol Oxidoreductases↗