Minimal change nephropathy and interstitial nephritis associated with diclofenac.
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Biopsy↗
Biomedical subjects
J Wolters
Publications and source records attributed to J Wolters.
Collection of published 5S and 5.8S ribosomal RNA sequences.
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Animals↗
The metabolic disposition of flucloxacillin in patients with impaired kidney function.
The fate of flucloxacillin and its active metabolite hydroxyflucloxacillin was studied in a group of patients with impaired kidney function. Flucloxacillin was administered orally or intravenously. Peak levels of hydroxyflucloxacillin were obtained between 150 and 250 min after the administration of flucloxacillin. The plasma concentrations obtained after a therapeutic dose of flucloxacillin were well above the concentration (i.e. 1-2 microgram/ml) generally considered to be the effective minimum for isoxalyl penicillins. The plasma half life of the metabolite was twice as long as that of flucloxacillin (295 min and 154 min, respectively). The nonprotein-bound fraction of hydroxyflucloxacillin in plasma from patients was twice as large as that of its parent compound (16.2 vs. 8.1%). This was also observed in normal human plasma, although protein binding in the latter was higher than in uraemic plasma. Some accumulation of hydroxyflucloxacillin may occur during flucloxacillin therapy with dosage intervals of 6 h.
Adult↗
Cell growth and tRNA-lys4 synthesis in mouse 3T3 cells.
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Animals↗
[Unilateral simultaneous primary double tumor of the lung diagnosed on the basis of cytological examination of the sputum].
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Adenocarcinoma↗
A fast method for arranging DNA sequence fragments.
A method is described which allows efficient arrangement of DNA sequence fragments and, based on this arrangement, reconstruction of a complete DNA sequence. The concepts and algorithms used are based on the mathematical theory of graphs. The amount of human interaction required is considerably reduced compared to existing methods. An experiment with a set of 168 fragments yields a DNA sequence of about 5800 bases almost automatically.
Base Sequence↗