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Biomedical subjects

J Witt

Publications and source records attributed to J Witt.

At least 37 records · Page 2Linked to original sources
PubMed1987

Experience in surgical treatment of pulmonary and bronchial tumours in childhood.

From the patient material of three paediatric surgical centres and the patient material of the paediatric surgical hospitals of Zurich, Switzerland and Leipzig, GDR, 24 cases of lung and bronchial tumours are reported. The aim of this review is to show a spectrum of the cases observed in our region. The most frequent of these very rare tumours was pulmonary blastoma, followed by endobronchial adenoma in its different variants. Since only the latter can be endoscopically diagnosed, endoscopy should be carried out as early as possible when the diagnosis is not clear. Cystic lung disease seems to be particularly frequently associated with pulmonary blastomas. Uncertainties in diagnosis and therapy owing to the rareness of these diseases cause further problems.

Bronchial Neoplasms↗
PubMed1987

The measurement of TcPO2 and TcPCO2 in newborn infants at 44 degrees C, 42 degrees C and 37 degrees C after initial heating to 44 degrees C.

Prolonged measurement of the transcutaneous O2 and CO2 tension at an electrode temperature of 44 to 45 degrees C often causes a second degree burn of the underlying skin. To avoid this, we compared the readings at 44 degrees C, 42 degrees C and 37 degrees C, after 2 hours pre-heating of the skin by the electrodes at 44 degrees C. In order to eliminate the electrodes' own temperature coefficients, electrodes with a built-in temperature correction were used. The changes observed therefore represent changes in the O2 and CO2 tension in the skin. The obtained values were compared to repeated arterial samples. We found that the TcPO2 and TcPCO2 values obtained at 42 degrees C and 37 degrees C were lower than those obtained at 44 degrees C, but when corrected for the in vivo temperature coefficients previously found by us the TcPO2 values at 42 were quite similar to the 44 degrees C values, whereas the 37 degrees values remained lower. TcPCO2 values at 44, 42 and 37 degrees were all similar. The temperature coefficient of PO2 was calculated to be 0.044 +/- 0.008 and for TcPCO2 as 0.049 +/- 0.007.

Blood Gas Monitoring, Transcutaneous↗
PubMed1983

Hereditary hypofibrinogenemia with fibrinogen storage in the liver.

A family with hereditary autosomal dominant hypofibrinogenemia is described. The outstanding feature is massive deposition of fibrinogen/fibrin within hepatocytes, faintly visible in routine microscopic sections, but clearly demonstrable by immunohistologic techniques. Circulating fibrinogen shows normal electrophoretic mobility of A alpha-, B beta-, and gamma-chains. We assume that the hereditary defect in this family interferes with fibrinogen release from hepatocytes. Clinically there are fluctuating slight elevations of serum transaminase levels. Hemostasis and wound healing are undisturbed.

Adult↗
PubMed1983

Beneficial effects of dopamine combined with intravenous nitroglycerin on hemodynamics in patients with severe left ventricular failure.

Hemodynamic effects of dopamine and intravenous nitroglycerin alone, and in combination, were studied in 27 patients with severe left ventricular failure. Dopamine alone increased cardiac index from 1.8 to 2.5 l/min/m2 but also increased wedge pressure from 24 to 30 mm Hg and heart rate from 88 to 101 beats/min. Arterial oxygen saturation fell from 92% to 87% (p less than .001). Nitroglycerin alone had a lesser effect on cardiac index (1.8 to 2.2 l/min/m2) but decreased wedge pressure from 26 to 16 mm Hg and heart rate from 91 to 86 beats/min. Arterial oxygen saturation fell from 91% to 90% (NS). Combined dopamine and nitroglycerin administration resulted in optimal hemodynamics, with cardiac index of 2.9 l/min/m2, wedge pressure of 17 mm Hg, and heart rate of 96 beats/min. Arterial oxygen saturation remained low at 88% in spite of the reduction in left ventricular filling pressure, which probably reflects increased intrapulmonary right-to-left shunting coupled with increased pulmonary blood flow. These results suggest that the combination of dopamine with intravenous nitroglycerin should be considered for patients with severe left ventricular dysfunction who require temporary pharmacologic support.

Adult↗
PubMed1977

Beyong the cities.

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Communication↗