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Biomedical subjects

J Winer

Publications and source records attributed to J Winer.

53 records · Page 3Linked to original sources
PubMed1966

[Indomethacin].

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Arthritis↗
PubMedDate not supplied

Independence of gonadotropin and adrenal androgen secretion.

Five groups of 5 normal adult males have been studied. Group 1 received clomiphene, group 2 received exogenous FSH and group 3 testosterone. These three groups received drugs to stimulate LH and FSH, increase levels of FSH or suppress LH and FSH respectively. Circulating levels of testosterone (T), estrone (E1) and 17-hydroxyprogesterone (17-OHP) were altered while serum concentrations of androstenedione (A), dehydroepiandrosterone (DHA), dehydroepiandrosterone sulfate (DS) and urinary 17-ketosteroids (17-KS) were not. The other two groups of 5 adult males had adrenal androgen levels suppressed or stimulated while receiving dexamethasone or ACTH. Serum 17 OHP, A, DHA and DS levels and urinary 17 KS were affected while gonadotropins were unaltered. Hence, no relationship has been demonstrated between circulating levels of adrenal androgens and gonadotropins.

Adrenal Glands↗
PubMedDate not supplied

[Influence of knee synovectomy on the disease course in PCP patients].

72 patients with rheumatoid arthritis undergoing surgical synovectomy of knee joints (102 times) were followed up for five years at yearly intervals for their clinical condition and laboratory parameters (sed. rate, leukocytes, serum iron, rheumatoid factor and others). Findings were documented by use of a questionary. At the end of the study the result of synovectomy was compared with the preoperative disease state by use of the Steinbrocker-Criteria and laboratory findings; in addition influence of synovectomy on the postoperative course was investigated. The following conclusions were drawn. 1) Preoperatively seronegative patients exhibited better local long term recovery than seropositive patients. 2) In most patients synovectomized in stage I the disease did not progress during the study period. 3) Some of the patients showed retardation of immunoserologic disease activity for 2-3 years after synovectomy.

Adult↗
PubMedDate not supplied

Alveolar efficiency for CO2 in normal people and patients with chronic obstructive lung disease.

A simple test is described which measures the efficiency of the lungs in removing CO2. The test, initially described by Cumming et al. [5, 9], has been simplified to make it suitable for use in routine pulmonary function test laboratories. Results from 50 normal subjects are compared with values obtained from 20 patients with chronic airway obstruction. The alveolar efficiency for removing carbon dioxide was clearly impaired in this group of patients. The test is very easy to perform, even for patients with quite severe lung disease, and has the advantage of providing an indirect measure of arterial PCO2.

Adolescent↗