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Biomedical subjects

J Wilson

Publications and source records attributed to J Wilson.

At least 919 records · Page 51Linked to original sources
PubMed1969

Relationship of a degenerative tropical neuropathy to diet: report of a field survey.

A survey of neurological abnormalities in two Nigerian villages preselected for their differing consumption of cassava has shown that a degenerative neuropathy occurs with relatively high frequency in the village (Ososa) where cassava consumption was high.It is suggested that eating cassava results in exposure to cyanide, as shown by a raised plasma thiocyanate level, and that the latter, together with other factors, may contribute to the pathogenesis of "tropical neuropathy."

Biological Assay↗
PubMed1969

Awareness during caesarean section under general anaesthesia.

Investigation of a series of 150 obstetric patients, the majority undergoing caesarean section, showed the expected figure of 2% with factual recall. There was, however, a 17.3% occurrence of unpleasant recall-associated in 10 cases (6.6% of the total) with recall of pain. There was a negative correlation between the giving of a narcotic within six hours of the operation and the occurrence of unpleasant recall. Several other aetiological factors-age, parity, preoperative emotional tension, ventilation, nitrous oxide wash-out with oxygen, and nitrous oxide concentration-were investigated and no relation was found between them and unpleasant recall. It is suggested, therefore, that premedication still has an important function in light anaesthesia, using muscle relaxants, to prevent any form of unpleasant operative awareness.

Adult↗
PubMed1969

Patterns of plasma cobalamins in control subjects and in cases of vitamin B12 deficiency.

A method for thin-layer chromatography and bioautography of plasma cobalamins is described. It requires only 5 ml of blood. Results are reported in 35 healthy people and hospital controls, and in 14 cases of untreated pernicious anaemia. In the control group there were two major components, methylcobalamin and a component which is probably a mixture of hydroxocobalamin and deoxyadenosyl cobalamin. Many cases of untreated pernicious anaemia showed a characteristic pattern in which methylcobalamin was reduced in relation to hydroxocobalamin. This pattern was also seen in one vegan who was taking a diet without B(12) supplement. A minority of subjects showed traces of cyanocobalamin; this compound was not confined to smokers. The significance of the results and possible diagnostic utility of the technique are discussed.

Adult↗