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Biomedical subjects

J Wilson

Publications and source records attributed to J Wilson.

At least 613 records · Page 34Linked to original sources
PubMed1986

Aminothiadiazole (NSC 4728) in patients with advanced ovarian carcinoma. A phase II study of the Gynecologic Oncology Group.

Thirty-two evaluable patients with advanced epithelial ovarian cancer were treated with aminothiadiazole at a dosage of 125 mg/m2 weekly. Two patients had partial responses, 12 had stable disease, 16 had increasing disease, and two were inevaluable for response. Aminothiadiazole used in this dosage and schedule has minimal activity in ovarian carcinoma patients previously treated.

Antineoplastic Agents↗
PubMed1986

Mortality ratios, life expectancy, and causes of death in patients with Turner's syndrome.

In a prospective study of 156 female patients with Turner's syndrome who had survived infancy and been followed up for an average of 17 years there were 15 deaths. The expected mortality was 3.6. Sixteen of the patients had a congenital heart anomaly and five of the deaths occurred in this group. The 10 deaths in the remaining 140 were three times as many as expected. The reduction in life expectation was 12.5 years at age 1 year, 11 years at age 20, and 10 years at age 40. Deaths were due to a broad spectrum of diseases. In the sample as a whole there were eight deaths from diseases of the circulatory system. This number is significantly greater than expected, but four were due to congenital heart disease. When patients with congenital heart disease were omitted from the sample the mortality from circulatory disorders was not significantly increased. Within the category of circulatory disorders there were three deaths from dissection of the aorta, a number which is greatly in excess of the expected. Two of these patients had no previous evidence of heart disease.

Female↗
PubMed1986

Patients' wants versus patients' interests.

Should we treat other people according to what they want (their own values), or according to what we take their best interests to be? If they have given us no mandate to decide for them, their values should prevail. This applies not only to allowing but also to assisting them to get what they want. Taking this seriously in medical practice involves a lot of communication between doctor and patient, and a lot of research to establish a typology of patients in respect of their wants. The results would seriously affect doctor-patient relationships and the organisation of general practice and hospital care. It is with this, rather than dramatic 'moral problems', that medical ethics should be chiefly concerned.

Communication↗
PubMed1986

A pharmacodynamic evaluation of midazolam as an antiepileptic compound.

Midazolam is a water soluble 1,4 benzodiazepine which is suitable for intramuscular administration. It is currently used for pre-medication and the induction of anaesthesia. Its antiepileptic properties have been evaluated by studying its effect on interictal spikes on the EEG of six adult epileptic patients. The results indicate that intramuscular midazolam 15 mg is more effective than intramuscular diazepam 10 mg in abolishing interictal spikes and as effective as intravenous diazepam 20 mg five minutes after administration.

Adult↗
PubMed1986

The reliability of axis V of DSM-III.

The authors studied the reliability of axis V of DSM-III by analyzing ratings of 97 psychiatric inpatients made by a multidisciplinary team of clinicians. The intraclass correlation coefficient for ratings of the overall sample was .49, lower than the figure found during the DSM-III field trials. The psychiatric diagnosis, age, ethnicity, marital status, and sex of the patient did not significantly influence reliability. The authors recommend more explicit instructions in the administration of the scale, the use of a standardized interview, and more training for raters as ways of increasing reliability.

Adaptation, Psychological↗
PubMed1986

Towards holistic social work practice in general medical settings.

This paper describes the development by field educators and social work students of a generalist model of practice related to work with general medical practitioners. The model developed outlines the values, knowledge and skills required to respond to the problems presented by intervening in a wide range of social systems. Effective social work practice is related to successful collaboration with the doctors. This is facilitated when there are close administrative links and when both groups are aware of the different perceptions on client/patient care. Conflict resolution is facilitated when the social worker encourages a focus on what is best for the client/patient and can articulate and demonstrate a practice perspective that links interaction among social, economic, political and health factors in people's lives.

Aged↗
PubMed1986

Problems of cyclosporine localization in the renal tissue.

The aim of the present investigation was to localize cyclosporine (CSA) in the rat kidney. The experimental approaches included autoradiography after i.v. injection of 3H-CSA, immunofluorescence after i.v. injection of fluorochrome labeled CSA and immunohistochemistry using the rabbit-alpha-CSA antibody. It was not possible to localize CSA in specific structures of the rat kidney. Finally, immunohistochemistry of human renal tissue gave only an unspecific staining of proximal tubular cells, which was lost when the antibody was absorbed on renal tissue homogenate. In vitro binding of 3H-CSA on renal homogenate indicated only unspecific absorption of the highly lipophilic compound; no specific binding was detected on cytosolic renal fractions. The failure to demonstrate CSA in tubular or arteriolar lesions might have been due to the fact that the affinity of binding is too low for detection, or that CSA does not accumulate within these structures.

Animals↗
PubMed1985

Acquisition of glial fibrillary acidic protein-containing fibres by astroglial cells in primary culture is orchestrated by a communicable factor.

In a previous study we discovered that primary cultures initiated from the whole brain of 21-day foetal rats contained astroblasts that concertedly acquired glial fibrillary acidic protein (GFAP) fibres. The mechanism of this burst of cytoskeletal differentiation could not be investigated in these cultures because it occurred too quickly (completed within 2 h). We report that cultures initiated from the region of the third ventricle display an extended burst of GFAP acquisition whose rate could be markedly reduced by medium changing. Temporary medium deprivation or the addition of cytosine arabinoside to the growth medium had no effect. Our findings suggest that an as yet uncharacterised communicable factor is involved in the orchestration of cytoskeletal differentiation in culture. This factor may be responsible for synchronising the appearance of GFAP-positive cells in the periventricular regions of the foetal brain.

Animals↗