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Biomedical subjects

J Wilson

Publications and source records attributed to J Wilson.

At least 343 records · Page 19Linked to original sources

The continuum of care for older people.

The introduction of casemix in hospitals has increased concerns about cost-shifting to community services. There has been little evidence with which to test claims about shifting balances in the continuum of care, in particular for major user groups like older people. These matters have come into greater prominence with the Council of Australian Governments Communique which agreed in April to radical reforms of health and community services. We used an existing longitudinal study of people aged 60 years and over in the community of Dubbo, New South Wales, to study hospital and aged care service use over 50 months. Fifty-five per cent of those studied were hospitalised but only 1.7 per cent were admitted to nursing homes over the period. In the 12 weeks after hospital discharge, 24 per cent received Home and Community Care services, while 78 per cent visited a general practitioner. All post-acute community services over 12 weeks after discharge cost an average of $150. In the light of this new evidence, current proposals for structural reform are critically discussed.

Aftercare↗

Awakening the sleeping giant: mainstreaming efforts to decrease tobacco use in an HMO.

Group Health Cooperative (GHC) of Puget Sound is developing, within a framework of quality improvement, a comprehensive population-based approach to decreasing the prevalence of tobacco use. Broad organizational support has been obtained, centralized support is being integrated with clinic-level activity, local ownership of outcomes is encouraged with empowerment of health care teams, and support for community and policy-based activities is being provided. GHC's smoking prevalence has decreased from 25% to 15.5% over the past decade, while the state of Washington's prevalence declined from 23.7% to 21.8%.

Community Health Planning↗

Assessment of aerobic and anaerobic demands of dinghy sailing at different wind velocities.

The aim of this study was to assess the oxygen uptake (VO2), heart rate (HR) and blood lactate concentration ([Lab]) during actual dinghy sailing at different wind velocities. Eight top class Laser sailors volunteered to participate in the study. In the laboratory, each subject performed an incremental exercise test on a cycle ergometer to the point of exhaustion. Maximum oxygen uptake (VO2max) and maximum heart rate (HR max) were assessed by means of a Cosmed K2 (K2) portable oxygen analyser while the accuracy of the K2 was simultaneously examined by comparing it with the Douglas bag method. On water each subject underwent a 10 minute continuous upwind sailing test. The average percentages of VO2max and HR max during sailing and the post-test [La(b)] were 39 +/- 6%, 74 +/- 11% and 2.3 +/- 0.8 mM, respectively. Values of the three measured variables for each subject were significantly correlated to wind velocity (r = 0.73, 0.87 and 0.88, respectively). The results of the study suggest that the metabolic and cardiorespiratory demands of dinghy sailing predominantly depend on the wind conditions. Aerobic capacity is only moderately taxed in dinghy sailing and should not be emphasized in training, whereas anaerobic metabolism plays an increasing role in stronger winds.

Adult↗

Clinical risk management in theatres. Professional practice: are you a team player?

Adverse patient outcomes in theatres are most frequently caused by a breakdown in the continuity of care as the patient moves through the operating theatre suite. The effective management of clinical risk of liability exposures requires a co-ordinated, integrated theatre process which focuses on providing safe, high quality patient care. This article will cover the main areas of concern to theatre nurses, ways of addressing the risk exposure and providing the best service for patients.

Humans↗

Clinical risk management. Building provider awareness in the administration of anaesthesia.

The area of anaesthesia has long been the focus of risk management concerns. This article will address a case study based on some of the high risk issues. Although the environment in which anaesthesia is administered is usually a carefully controlled area, the anaesthetic agents and the patient's response to them can be unpredictable. Injuries sustained as a result of anaesthetic administration and anaesthesia can be serious with life-long and costly disabilities and even death. Tables 1 and 2 highlight the Risk Management areas to address in anaesthesia and Tables 3 and 4 the risk issues which have occurred from over 20 years experience in the USA. (MMI Companies Inc. 1993). Many of these issues will be discussed in the case study scenario. Further reading around the risk issues will also be suggested.

Adult↗

Individual susceptibility to alcoholic pancreatitis: still an enigma.

Evidence is increasing that individuals vary in their susceptibility to alcoholic pancreatitis. Numerous investigators have attempted to account for this individual susceptibility by studying associations between alcoholic pancreatitis and potential risk factors. Those studies, reviewed here, have focused on the amount, type, and pattern of alcohol consumption, genetic markers (such as blood groups, HLA phenotypes, alpha 1-antitrypsin, and alcohol dehydrogenase isoenzyme distribution), diet, hypertriglyceridemia, tobacco consumption, and pancreatic ischemia. Associations between pancreatitis and several of these factors have been reported, but many studies offer conflicting conclusions. A number of studies are difficult to interpret because of methodologic problems, particularly with regard to inadequate controls and small numbers of index subjects. At present, the evidence is insufficient for one to conclude that any of the above-mentioned factors are well-established risk factors for pancreatitis. As a result, individual susceptibility to alcoholic pancreatitis remains unexplained. Clarification of potential risk factors may ultimately lead to the ability to prevent this relatively common disorder, but additional, appropriately designed studies are required.

Alcohol Drinking↗

Maternity policy. Caroline: a case of a pregnant teenager.

The government's health of the Nation strategy aims to reduce the incidence of conceptions among the under 16s by at least 50% by the year 2000. Teenagers need contraceptive services that they find approachable and easily accessible. Traditional family planning arrangements are not necessarily appropriate. Sex education in schools is sometimes too biological and does not relate to the teenager's personal situation and concerns. The main concern about teenage parents may be the long-term social rather than health consequences.

Adolescent↗

Residue Gln-30 of human erythrocyte anion transporter is a prime site for reaction with intrinsic transglutaminase.

Elevating the intracellular concentration of Ca2+ ions in human erythrocytes leads to the formation of membrane-associated polymers, composed of skeletal and cytoplasmic proteins. The anion transporter band 3 serves as a membrane anchor for this N epsilon-(gamma-glutamyl)lysine cross-linked polymer. The reaction is catalyzed by an intrinsic transglutaminase, and it can be observed in broken cells merely by the addition of Ca2+. Certain primary amines, such as dansylcadaverine, inhibit the process by virtue of competition against the epsilon-lysyl or donor functionalities of the protein substrates. Dansylcadaverine itself becomes incorporated into the enzyme-specific gamma-glutaminyl or acceptor residues, blocking these from participating in the formation of protein-to-protein cross-links. This labeling procedure, coupled with an anti-dansyl antibody affinity procedure to isolate dansyl-labeled compounds, was employed to identify Gln-30 as the preferred transglutaminase-reactive acceptor site in the band 3 protein.

Amino Acids↗

The gastrointestinal absorption of neptunium, plutonium and americium in a primate (C. jacchus).

Mixtures of Np, Pu and Am were administered to primates (C. jacchus) by gastric intubation to measure their fractional gastrointestinal absorption (f1 values). The values obtained were about 2 x 10(-3) and 1 x 10(-3), respectively, for Np and Pu administered as the citrate, and 2 x 10(-3) and 6 x 10(-4), respectively, for Pu and Am in potato. The significance of these values in terms of absorption in humans is discussed.

Americium↗

Isolated dihydroxyacetonephosphate acyltransferase deficiency presenting with developmental delay.

A boy aged 21 months who was being investigated for developmental delay and failure to thrive was found to have punctate epiphyseal calcification. He had no evidence of rhizomelic shortening of the limbs or cataracts. Investigation revealed defective plasmalogen synthesis due to isolated deficiency of dihydroxyacetonephosphate acyltransferase (DHAP-AT). The parents were consanguineous and a sister was similarly affected, suggesting autosomal recessive inheritance. Hitherto, recessively inherited isolated DHAP-AT deficiency has only been described in patients with a phenotype similar to that of rhizomelic chondrodysplasia punctata. This report indicates that the same biochemical disorder can be associated with a less severe phenotype.

Acyltransferases↗

Effect of graded exercise on esophageal motility and gastroesophageal reflux in nontrained subjects.

The effects of graded exercise on esophageal motility and gastroesophageal reflux were evaluated in nine nontrained subjects, using a catheter with three strain-gauge transducers connected to a solid-state datalogger and an ambulatory intraesophageal pH monitor. Subjects exercised on a stationary bike at 45%, 60%, 75%, and 90% of peak O2 uptake (VO2 max). Durations of exercise sessions and rest periods varied among subjects. Studies were performed after an overnight fast and subjects received only intravenous infusion of 5% glucose solution during the study. Plasma concentrations of gastrin, motilin, glucagon, pancreatic polypeptide (PP), and vasoactive intestinal peptide (VIP) were determined at rest and before and after each exercise session. The duration, amplitude, and frequency of esophageal contractions declined with increasing exercise intensity, and the differences were significant (P < or = 0.05) for all three variables at 90% VO2 max. The number of gastroesophageal reflux episodes and the duration of esophageal acid exposure were significantly (P < or = 0.05) increased during exercise at 90% VO2 max. Plasma regulatory peptide concentrations showed no significant changes between rest and the various exercise sessions. Thus, exercise has profound effects on esophageal contractions and gastroesophageal reflux, which are intensity dependent. These effects were not mediated by the hormones measured. The results were similar to those observed in highly trained athletes, suggesting that the effects of exercise on esophageal function are similar in trained and nontrained subjects performing at similar percentages of VO2 max, even though the absolute levels of exercise achieved in each group are different.

Adult↗