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Biomedical subjects

J Wills

Publications and source records attributed to J Wills.

32 records · Page 2Linked to original sources

Techniques for the measurement of the local myocardial extraction efficiency for inert diffusible contrast agents such as gadopentate dimeglumine.

We have previously shown that the concentration of Gd-DTPA as a function of time ([Gd-DTPA]t(t)) in the myocardium following an intravenous bolus injection of Gd-DTPA can be modeled using the Modified Kety Equation. Fitting this model to measurements of [Gd-DTPA]t(t) in a region of myocardium would allow the determination of myocardial distribution volume (lambda) and the product of flow (F) and extraction efficiency (E), i.e., FE. Thus, to measure F, E must be known. We describe here techniques developed to measure local values of E in normal and diseased myocardium. These techniques are valid for any inert diffusible MR contrast agent.

Animals↗

Measurement of the extraction efficiency and distribution volume for Gd-DTPA in normal and diseased canine myocardium.

We have previously shown that the myocardial Gd-DTPA concentration ([Gd-DTPA]t(t)) after a bolus injection of Gd-DTPA can be predicted by the Modified Kety Equation (MKE). If [Gd-DTPA]t(t) can be determined by MRI and the data fit to the MKE, then the distribution volume (lambda) of Gd-DTPA and the myocardial flow (F) times the extraction efficiency (E), i.e., the FE product, can be determined. Therefore F can only be quantified if E is known. We measured the global E in vivo in normal canine myocardium, and measured E and lambda, in vitro, locally in normal, acute ischemic (n = 5; coronary artery occlusion < 4 h), infarcted (n = 4; coronary artery occlusion, 6 days) and reperfused (n = 4; coronary artery occlusion 2 h, and reperfusion 2 h and 6 days) myocardium. Results indicate that E differs with F and with individuals and consequently, F cannot be quantified using the MKE unless the local E is also determined in vivo.

Animals↗

The days ahead.

How are government controls affecting healthcare foodservices?Are growing elderly & outpatient populations changing foodservices' missions. What are the hottest trends? As members of the American Society for Hospital Food Service Administrators prepared for their annual meeting in Orlando, FM queried 11 Southeastern directors to learn their most pressing concerns & how they are positioning their departments for the future.

Aged↗

Percutaneous transthoracic needle aspiration lung biopsy in the community hospital.

In 108 cases in which transthoracic needle aspiration biopsies were studied at Raleigh General Hospital in Beckley, West Virginia, from 1983 through 1987, the pathologic diagnoses were compared and correlated with the subsequent clinical course. The procedure was performed under C.T. guidance. Correlation of pathology with the clinical course yielded 67 per cent (72 cases) true positives, 19 per cent (20 cases) true negatives, four per cent (four cases) false negatives, zero per cent (zero cases) false positives, and 11 per cent (12 cases) indeterminates. In 23 per cent of the cases, there were radiologically demonstrated pneumothoraces, with placement of a chest tube required in 12 per cent of the cases. Hemoptysis occurred in eight per cent of the patients. The results confirmed the appropriateness of using transthoracic needle aspiration biopsies at this hospital.

Biopsy, Needle↗

Isolation of Chlamydia psittaci from cases of conjunctivitis in a colony of cats.

This report describes the isolation in cell cultures of Chlamydia psittaci from cases of conjunctivitis in a colony of cats. The organism was identified in McCoy cell monolayers by staining the intracytoplasmic chlamydial inclusions with a fluorescent antibody technique, and serological evidence of chlamydial infection in cats was obtained by indirect immunofluorescence. The possible role of C psittaci as an ocular, upper respiratory and reproductive tract pathogen in cats is discussed.

Animals↗

Estimates of physician requirements for 1990 for the specialties of neurology, anesthesiology, nuclear medicine, pathology, physical medicine and rehabilitation, and radiology. A further application of the GMENAC methodology.

The Graduate Medical Education National Advisory Committee (GMENAC) adjusted needs-based model for determining physician requirements was applied to the specialties of anesthesiology, neurology, nuclear medicine, pathology, physical medicine and rehabilitation, and radiology, which had not been completed at the time of the original GMENAC final report. Physical medicine and rehabilitation continues to be projected as a shortage specialty; anesthesiology is in near balance. Neurology and pathology are no longer projected to be specialties of oversupply, but rather to be in near balance. Diagnostic radiology continues to be projected as a specialty of oversupply; therapeutic radiology is projected to be in near balance, as is nuclear medicine. The GMENAC aggregate-requirements estimates are thus revised upward from 466,000 to 473,000 full-time equivalent physicians for 1990, reducing the projected surplus from 15.0% to 13.3%.

Anesthesiology↗

Manpower requirements in ophthalmology.

Ophthalmology manpower requirements estimates presented to the Graduate Medical Education National Advisory Committee (GMENAC) are explained and compared to previous estimates published by the American Academy of Ophthalmology, Both studies used similar methods but reached different conclusions; the reasons for this are explored and shown to be due principally to (1) differences in projected hours per week spent in patients care by ophthalmologists, and (2) differences in the medical workload traceable to differences in estimated visit time and needs for care in the area of systemic ophthalmology. The manpower implications of the principal contributors to the ophthalmology workload are examined, and differences between the two studies regarding these conditions are documented. Areas for further research are suggested.

Forecasting↗

Minnesota: the impact of a community hospital's psychiatric unit on a regional state hospital.

A community hospital serving part of a state hospital's receiving area opened a psychiatric inpatient unit. The authors studied the impact of the new unit on the number of psychiatric admissions to the state hospital, and also sought to determine if the two facilities provided duplicate services to the area. In comparing admission rates to the state hospital before and after the opening of the community unit, they found the unit did not have a significant impact. In comparing sample groups of patients at the two hospitals, they found that each served a different socioeconomic group and therefore did not offer duplicate services.

Hospitals, Community↗

Nurse managers in Australia: mentoring, leadership and career progression.

Identification of those leadership qualities which nurses believe led to their successful attainment of a nursing management position may help in understanding how to identify and foster leadership potential amongst nursing staff. This study asked nurse managers to indicate the important factors which influenced and facilitated their entry to management positions with a particular reference to the development of leadership characteristics. The results suggest that the leadership qualities we expect nurse managers to display evolve in a largely random way. Additionally, there is evidence that the development of leadership skills and attainment of management positions remains fragmented and random in nature. Because of this, individual nurse managers develop leadership skills almost by default using informal strategies to learn and develop. These findings should provide direction to educational providers and senior managers who seek to develop future leaders and managers.

Attitude of Health Personnel↗

Inner strength.

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Breast Implants↗