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Biomedical subjects

J Williamson

Publications and source records attributed to J Williamson.

At least 217 records · Page 12Linked to original sources
PubMed1977

Heterogeneity of rabbit muscle creatine kinase and limited proteolysis by proteinase K.

By using sodium dodecyl sulphage/polyacrylamide-gel electrophoresis it was shown that rabbit muscle creatine kinase, both in a homogenate and purified, appears to be composed of a mixture of two peptides (mol.wts. 42100 and 40300) differing in length by about 15 amino acids. It is found that low concentrations of proteinase K from the fungus Tritirachium album can cleave about 38 amino acids from each chain of creatine kinase, leaving two large fragments (mol.wts 37700 and 35500). Scission of the whole enzyme was found to be concomitant with complete loss of enzyme activity. MgADP in the presence of absence of creatine slowed the rate of proteolysis by about 50%, but the transition-state analogue complex creatine-NO3--MgADP appeared to protect completely. The time course for the proteolytic inactivation in the presence of this complex, but not in its absence, was biphasic.

Adenosine Diphosphate↗
PubMed1977

Sjogren's syndrome in SLE: Part I. The frequency of the clinical and subclinical features of Sjogren's syndrome in patients with SLE.

Clinical features of Sjogren's syndrome were found in 31 percent of 32 patients with SLE. Eight patients had features of KCS while four had xerostomia. Subclinical abnormalities were found in six other patients tested with sialography and labial salivary gland biopsy and there were abnormalities in 65 percent of SLE patients in whom labial salivary gland biopsy was performed. The prevalence of Raynaud's phenomenon and renal disease in SLE patients with and without Sjogren's syndrome were similar but four of the five patients with SLE and an erosive arthritis had symptomatic Sjogren's syndrome.

Arthritis, Rheumatoid↗
PubMed1977

Sjogren's syndrome in SLE: Part 2. An examination of the clinical significance of Sjogren's syndrome by comparison of its frequency in typical and atypical forms of SLE, overlap syndromes and scleroderma.

The clinical features of Sjogren's syndrome were found in 24 percent of Glasgow patients with SLE without other atypical features. Sjogren's syndrome was found in one (13 percent) of a group of eight patients with features of both SLE and scleroderma, one of three patients with features of both polymyositis and scleroderma and in three of 12 (25 percent) patients with scleroderma. The highest frequency of Sjogren's syndrome was seen in six patients with features of SLE and an erosive polyarthritis, five of whom (83 percent) had Sjogren's syndrome. In patients satisfying diagnostic criteria for SLE no relationship between the presence of Sjogren's and the presence or absence of renal disease was found.

Adolescent↗
PubMed1977

The effect of fibrinolytic inhibition in the resolution of experimental vitreous hemorrhage.

Complete inhibition of vitreous fibrinolytic activity with 4-amino-methylcyclohexane carbonic acid was associated with significantly delayed resolution of vitreous hemorrhages in rabbits. However, polyacrylamide gel electrophoresis indicated but a slight delay in the removal of the fibrin component of vitreous clots, and most of the residual vitreous opacity comprised intact red blood cells. Fibrin degradation products may act as chemotactic agents, promoting the removal of red blood cells by leukocytes; hence, their absence in treated rabbits might explain in part the delayed red blood cell clearance.

Absorption↗
PubMed1976

Drug effects on the fine structure of Trypanosoma rhodesiense: puromycin and its aminonucleoside, Cordycepin and Nucleocidin.

The effects of four trypanocidal adenine nucleosides on the fine structure of a monomorphic strain of Trypanosoma rhodesiense have been examined. All four drugs, Puromycin and its aminonucleoside, Cordycepin and Nucleocidin, induced electron-lucent cytoplasmic clefts in the cytoplasm, which were generally acicular or spindle-shaped, with long axes lying in any direction. The clefts had an intimate relationship with the rough endoplasmic reticulum. The drugs also produced excessive lysosomal vacuolation, and two, Cordycepin and Nucleocidin, caused nucleolar fragmentation and probable segregation, indicative of interference with RNA synthesis. The significance of the lesions is discussed in relation to known properties of adenine nucleoside drugs.

Adenosine↗
PubMed1976

An ophthalmic study of ibuprofen in rheumatoid conditions.

A total of 247 patients suffering from rheumatoid arthritis and allied conditions were referred for routine ophthalmological examination with particular reference to ocular rheumatoid involvement. Of these, 197 were already receiving ibuprofen before their first assessment while 50 had a baseline assessment before commencement of ibrupofen therapy. All patients were examined on at least two occasions. No macular lesions were discovered which could be directly attributed to ibuprofen therapy.

Adult↗