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J Williams

Publications and source records attributed to J Williams.

At least 1,063 records · Page 59Linked to original sources
PubMed1980

A quantitative approach to perceived health status: a validation study.

The current recognition of the importance of perceived health status as a predictor of need for, and utilisation of, health services has led to attempts to produce indicators which assess subjective rather than objective health problems. The development of the Nottingham Health Profile is described, together with a study which tested the validity of the instrument on four groups of elderly people differing in health status. The results showed that the profile was capable of discriminating between groups differing in terms of diagnosed chronic illness, number of consultations at primary care level, and physiological fitness. Age, sex, and marital status were not significant overall in affecting scores. In these elderly subjects, perceived health status accorded well with objective health status. Further tests of the profile are now taking place on younger groups of subjects.

Affective Symptoms↗
PubMed1979

The diabetic foot.

Explore the source record for details and available documents.

Administration, Topical↗
PubMed1979

Automated determination of total plasma cholesterol: a serum calibration technique.

The automated (AutoAnalyzer II) determination of cholesterol in nine serum pools in the concentration range 3.465-8.871 mmol/l, gave results that were approximately 10% higher than reference values when the analyses were based on unesterified cholesterol standards containing the same amount of water as the sample extracts (1963 analyses in 12 laboratories during a 12 month period; automated value = 0.032 + 1.10 X (Reference value)). A serum calibration procedure was successful ilues, and was equally effective in correcting the values observed for aliquots of 368 fresh-frozen plasma samples analyzed in each of the 12 laboratories during a 38 month period.

Autoanalysis↗
PubMed1979

The action of DL-2,4-diaminobutyric acid on the cataleptogenic effects of pilocarpine and alpha-flupenthixol in rats.

The existence of a strionigral GABA-ergic pathway having an inhibitory effect on the nigrostriatal dopaminergic system has been proposed. The work reported in this paper was undertaken to investigate whether modification of the GABA-eric system by the GABA neuronal uptake inhibitor DL-2,4-diaminobutyric acid (DABA) would affect cholinergic (pilocarpine) and/or neuroleptic alpha-flupenthixol (alpha-FPT) induced catalepsy. DABA pretreatment was shown to enhance significantly both alpha-FPT and pilocarpine induced catalepsy. DABA alone had no cataleptic activity. The results are interpreted as supporting the existence of an inhibitory strionigral GABA-ergic pathway.

Aminobutyrates↗
PubMed1979

Renal hemodynamics and the renin--angiotensin system in cirrhosis: relationship to sodium retention.

Renal hemodynamics and the renin-angiotensin-aldosterone system were investigated in 15 cirrhotic patients without renal failure on controlled sodium intake of 140-160 mEq/day and related to the degree of sodium retention as measured by urinary sodium excretion. Fourteen patients were free of clinical ascites when studied. The distribution of renal blood flow was measured by the noninvasive technique of computerized radioisotope renography. In 11 patients, outer cortical renal plasma flow, expressed as a percentage of total effective renal plasma flow, was directly proportional to sodium excretion (P less than or equal to 0.01). Three patients with severe sodium retention (UNa.V less than or equal to 10 mEq) had estimated outer cortical renal plasma flows of less than or equal to 274 ml/min/1.73 M2 as compared to eight cirrhotics with better (UNa.V greater than or equal to 50 mEq) sodium tolerance (mean = 438 ml/min/1.73 M2). A significant inverse correlation (P less than or equal to 0.01) existed between outer renal cortical blood flow and plasma renin activity. No significant relationship was observed between glomerular filtration rate, total effective renal plasma flow, plasma aldosterone concentration and sodium excretion. These results provide further evidence that a renal vascular abnormality exists in cirrhosis, and that diminished outer cortical renal perfusion is related to the elevated renin levels and sodium intolerance observed in cirrhotic patients.

Angiotensin II↗
PubMed1979

Adenocarcinoma in multilocular renal cyst.

The fifth case of a patient with a multilocular cystic nephroma with an associated adenocarcinoma is reported. The histology of the tumor and biochemical analysis of the cyst fluid are presented and the literature summarized.

Adenocarcinoma↗
PubMed1979

Fatal myocardial toxicity during continuous infusion intravenous isoproterenol therapy of asthma.

We recently utilized continuous infusion intravenous isoproterenol in the treatment of respiratory failure in an 18-yr-old steroid-dependent asthmatic female. Aminophylline, hydrocortisone, aerosolized isoetharine, and oxygen were also administrered. The patient responded to this therapy, with PaCO2 falling from 70 torr to 33 torr in 18 hr. The maximum isoproterenol dosage administered was 0.32 microgram/kg/min. Thirty-six hours following the institution of therapy, while the isoproterenol was being tapered, the patient experienced an increase in respiratory distress followed by cardiac arrest. Postmortem examination revealed multiple small areas of myocardial necrosis. These findings, unusual in asthma, probably were related to the effects of isoproterenol or the combination of isoproterenol and aminophylline on the stressed myocardium. The vulnerability of the hypoxic myocardium to the effects of isoproterenol suggests that careful cardiac monitoring is essential in the management of patients receiving this medication for treatment of respiratory failure secondary to severe asthma.

Adolescent↗