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Biomedical subjects

J Widimsky

Publications and source records attributed to J Widimsky.

36 records · Page 2Linked to original sources
PubMed1975

Effects of physical training on central haemodynamics and working capacity in myocardial infarction.

Changes in central haemodynamics and physical working capacity were followed in 23 patients with myocardial infarction: in 12 of them, after six-month intense physical training, and in 11, after an equal control period without training. The haemodynamic indicators revealed after rehabilitation a significant decrease in the exercise heart rate in comparison with the unchanged value in the controls. The changes in the other haemodynamic values were not significant. The pulmonary arterial end-diastolic pressure, regarded as an indicator of the left ventricular filling pressure, sustained no significant change by the training. Some additional changes, such as decreases in the arterial and venous oxygen pressure both at rest and during exercise, were found in both groups of patients. The physical working capacity increased significantly after rehabilitation in comparison to the control group. It is emphasized that no adverse influence upon the central haemodynamics was revealed in patients with myocardial infarction after intense training according to WHO criteria.

Blood Pressure↗
PubMedDate not supplied

Effect of prolonged high salt intake on atrial natriuretic factor's kinetics in rats.

Plasma atrial natriuretic factor (ANF) paradoxically decreases after 5 weeks (but not after 3 weeks) of 8% NaCl intake in normotensive rats. As this phenomenon remains unaccounted for by changes in ANF production, we studied the disappearance of [125I]ANF(99-126) from the circulation as an alternative explanation of plasma ANF decline. Following 5 weeks (but not 3 weeks) of an 8% NaCl diet, plasma concentrations of [125I]ANF were significantly decreased and metabolic clearance rate and volume of distribution were increased compared to control rats fed a 0.8% NaCl diet. By studying [125I]ANF tissue uptake we noted significantly greater peptide uptake after 5 weeks (but not after 3 weeks) of high salt consumption in several tissues. We hypothesize that prolonged (at least 5 weeks) 8% NaCl ingestion increases the density and/or affinity of ANF binding sites. These changes may be responsible for the previously observed decline in plasma ANF concentrations after a prolonged high salt intake.

Animals↗
PubMedDate not supplied

Central haemodynamics during exercise in patients with restrictive pulmonary disease.

Pulmonary precapillary hypertension present only during exercise is the first stage of corpulmonale. Examination of the reaction of central haemodynamics to exercise is the only way to detect it. In a model situation like unilateral pulmonary artery occlusion (UPAO) in healthy subjects, an increase in pulmonary artery pressure (Ppa) during exercise is a linear function of restriction of the pulmonary vascular bed and blood flow increase. Central haemodynamics during exercise in younger subjects after pneumonectomy (PNE) resemble the situation with UPAO provided the remaining lung is intact. In older patients after PNE the same rise of blood flow is associated with a considerably greater rise of Ppa. PNE patients compared to healthy individuals increase their cardiac output during exercise more by increasing stroke volume. Patients with pulmonary fibrosis show a disproportionate rise in Ppa in relation to flow. This is due to reduced distensibility of the pulmonary system. Hypoxia also seems to be involved in pulmonary hypertension during exercise. Pulmonary wedge pressure rises at work but remains within the normal range, even in patients having marked hypoxaemia at rest and during exercise. In idiopathic intersitial pulmonary fibrosis (IIPF), pulmonary hypertension during exercise is greater than in other forms of pulmonary fibrosis. Inhalation of oxygen during exercise in patients IIPF leads to a reversal of hypoxaemia but the decrease of Ppa is small and due to a passive decrease of cardiac output. Finally right ventricular function in restrictive pneumopathies is discussed.

Heart Ventricles↗