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Biomedical subjects

J Werner

Publications and source records attributed to J Werner.

At least 181 records · Page 10Linked to original sources
PubMed1981

Influence of cold adaptation on the activity of thermoresponsive neurons in thalamus and midbrain of the rat.

A group of 25 rats was adapted to cold by housing for five weeks at +3 degrees C. Using thermal stimuli of the scrotal skin, 53 recordings of warm-responsive thalamic and midbrain neurons were analyzed and compared with 84 control recordings from non-adapted rats. The activity of the analyzed neurons is characterized by a steep increase of firing rate above a certain temperature threshold zone. Between scrotal skin temperatures of 36 degrees and 38 degrees C the percentage of neurons with firing rates above the basal rate is higher, both in the thalamic and midbrain population of the cold adapted rats. It is concluded that after cold-adaptation the increase of firing rate starts on average at a lower temperature. The results are discussed in the context of findings of other authors on peripheral structures and on effector behaviour.

Acclimatization↗
PubMed1981

Strain specificity of serum antibody to the haemagglutinin of influenza A (H3N2) viruses in children following immunization or natural infection.

The specificity of serum anti-HA antibody from children immunized or infected with A/Victoria/75 (H3N2 or A/Texas/77 (H3N2) virus was examined using the single radial haemolysis test together with adsorption of antibody with three antigenic variants A/Hong Kong/68 (H3N2), A/Port Chalmers/73 (H3N2) and A/Victoria/75 (H3N2). The majority of young children reacted to vaccination or infection by producing strain-specific (SS) antibody to the homologous virus. A small proportion of children's sera contained cross-reacting (CR) antibodies capable of reacting with the haemagglutinins of all antigenic variants of the sub-type including A/HK/1/68. In contrast, most adults reacted immunologically to either vaccination or infection by producing CR antibody, reacting with all variants of the antigenic subtype including the prototype virus A/HK/1/68 (H3N2).

Adolescent↗
PubMed1981

Radionuclide imaging of experimental myocarditis.

The ability of 67Ga citrate and 99mTc pyrophosphate cardiac imaging to detect myocarditis was assessed in an experimental rabbit model. Twenty-three rabbits were imaged approximately 72 hours after infusion of i.v. norepinephrine. Diffuse cardiac uptake was found in 13 of 15 rabbits scanned with 67Ga. Tissue distribution studies documented significant myocardial uptake of 67Ga in those with positive scans. Precordial imaging and tissue distribution studies revealed no cardiac uptake in the eight rabbits scanned with 99mTc. Histologic examination of all 23 hearts revealed qualitatively similar, typical lesions of myocarditis. This study suggests that cardiac imaging with 67Ga may be useful in the detection of myocarditis.

Animals↗
PubMed1981

Fostering collaborative relationships.

Increasing patient care demands call for more productive working relationships between physicians and nurses. In hospitals where effective collaborative relationships are fostered, patient care is improved and the professional lives of both physicians and nurses are enhanced.

Humans↗
PubMed1981

[Endoscopic and histological alterations of the gastric mucosa in patients with chronic renal insufficiency (author's transl)].

Biopsies of mucosa from all regions of the stomach were obtained with endoscopic guidance from two groups of people. One group consisted of 80 patients who suffered from chronic renal insufficiency in various stages and had not yet been dialysed. The other group consisted of 80 healthy individuals. Both groups had the same age distribution. Histological examinations of the biopsies did not reveal significant differences between the two groups. The same was true for macroscopic examinations of stomach and duodenum. Changes indicating a so called "uremic gastritis" were not observed.

Adult↗
PubMed1980

[Influence vaccination: comparison of the effectiveness of two different vaccines].

In this paper, it is demonstrated that two influenza vaccines, differing in the H1N1 component (virus strain A/USSR/90/77 or virus strain A/Brazil/11/78) did not show significant differences with respect to the induction of H1N1 antibodies (as measured in the haemagglutination inhibition test) in the vaccination of 25 and 26 young female adults, whose age ranged from 17 to 25 years. It can be concluded that vaccines which differ in the H1N1 portion in this manner do not produce different immunological (i.e. also protective) reactions in vaccinated individuals. Both H1N1 virus strains could be considered to be practically of equal value for the influenza immunoprophylaxis against the H1N1 type.

Adolescent↗
PubMed1980

Thalamic burst firing--a neuronal code for temperature information$.

A total number of 840 neurons was extracellularly recorded from the rat's thalamus (ventrobasal complex, VB, and nucleus posterior, NPT) and from the midbrain (raphe nuclei, MB) while thermal stimuli were given to the hindlimbs, scrotal skin, and the tongue. Of all neurons found, 407 exhibited burst patterns; the highest percentage of burst cells was found in VB (50-85%) whereas only 1-015% of the NPt and MB neurons were burst cells. About one-half of all burst cells responded to peripheral temperature stimulation by changing their mean firing rate. The question dealt with in this paper is whether burst firing gives a more detailed information on thermal sensations than mean firing rate alone. Therefore, 40 burst cells (20 of which were thermo-responsive according to their mean firing rate) were further analyzed by evaluating several burst parameters such as burst frequency, number of spikes/burst and bursting index. However, when mean discharge rate did not respond to skin temperature, the burst parameters were not correlated with the stimulus, either. Hence it is concluded that the burst firing in the thalamic neurons investigated does not provide an additional detailed information of skin temperature.

Animals↗
PubMed1980

A contribution to the topography of temperature regulation in man.

By means of climatic chamber studies the steady-state curves of body temperature and effector mechanisms of temperature regulation in man are determined for different areas of the body. Under cold conditions local temperature differences are considerable, whereas under warm conditions, the distribution of body heat is much more uniform. Evaporative heat loss, directly measured, and skin blood flow, recorded by the fluvographic method, show considerable local differences under the influence of environmental temperature. This should be the consequence of a "distributed parameter control strategy", which may be adapted to special requirements, such as exercise or partial thermal stress of the body. The experimental results form the basis for a mathematical model of human temperature regulation, and for further experimental studies which are devoted to clarifying the strategy of regulation with local distributed parameters.

Adult↗
PubMed1980

[Local and systemic antibody response after vaccination with 3 different types of vaccines against influenza. II. Neuraminidase inhibiting antibodies (author's transl)].

Three types of inactivated bivalent influenza vaccines containing the A/Victoria/3/75 (A-Component) and B/Hongkong/8/73 (B-Component) antigens either as aluminium salt adsorbed whole virus (AlorbatTM, "A") and split virus (Begrivac STM, "B") or as fluid subunit (SandovacTM, "S") products were given to immunological homogeneous study groups of adults and children. The immune response was compared between the groups on the basis of systemic and local neuraminidase inhibiting (NI) antibody induction 4 weeks after vaccination. In evaluation of the serologic results the sea and nasal washings were tested in the ESSEN-NIT with use of the A/Eq(eq1)-VIC (N 2) recombinant antigen and the B/Hong kong/8/73 strain. The number of individuals (adults plus children) evaluated ranged from 33 to 35 per vaccine. The percentages of persons greater than or equal to 16 years old showing a significant (1.5 x, or greater) response to the A-component were 100%, 96% and 90%, respectively for the vaccine "A", "S" and "B"; the values for the B-component were 70%, 79% and 74%, respectively. The observed conversion rates in children ranged 70% to 100%. Local antibody formation was less pronounced, the percentages of significant conversions were scattered over a wide range from 13% to 80% yielding slightly better responses in children than adults. Taken altogether, the results of the trial indicate that the 3 vaccines studied induced appreciable concentrations of systemic antibodies to the neuraminidase antigen without significant differences between the vaccine types. This potency of the influenza vaccines to induce high titers of NI antibodies thus provides another marker for their immunogenicity and conceivably for their efficacy.

Adolescent↗