Search PubMed⌕ Search

Biomedical subjects

J Wells

Publications and source records attributed to J Wells.

At least 181 records · Page 10Linked to original sources
PubMed1981

The structural organization of the ventral posterolateral nucleus in the rat.

The structural plan of the ventral posterolateral nucleus (VLP) in the rat was analyzed by using a variety of techniques to study the pattern of distribution of the ascending afferent fibers and the synaptology of the neuropil within this somatosensory relay nucleus. Golgi stains, Fink-Heimer methods, HRP labeling methods, and electron microscopy were all used in the analysis. The neurons in VPL are aligned in rostrocaudal and dorsoventral rows that are roughly parallel to the curvature of the external medullary lamina (EML) and curve partially around the rostral pole of the ventral posteromedial nucleus (VPM). Golgi-impregnated sections reveal that the dendritic trees of the VPL neurons conform in general to the laminar pattern of VPL. Thick proximal dendrites extend about 25 mu m from the cell bodies. Most proximal dendrites are aligned with the laminae of VPL but the distal dendrites spread over many laminae within VPL. The inputs from the dorsal column nuclei (DCN) end only on proximal dendrites as large, round-vesicle terminals. About 20--25% of the small round-vesicle terminals originate in the cerebral cortex and synapse only on the distal dendrites. The third type of synapse contains many flattened vesicles and is of unknown origin. No serial synapses or vesicle-containing dendrites were observed. Input from the spinal cord projects to two segregated zones which are transitional between the ventral lateral nucleus (VL) and VPL rostrally and between the posterior thalamic complex (PO) and VPL caudally. Each transition zone contains neurons characteristic of both VPL and the adjacent region. Ascending afferent projections were demonstrated by the antegrade transport of HRP following injections into the ventral mesencephalon and by Fink-Heimer stains of degeneration resulting from small lesions of the DCN. Both methods indicate that large-caliber axons course parallel to each other and give off collaterals that diverge to widespread areas of the VPL. The widespread terminal fields that result do not conform to the laminar pattern of the nucleus. Small punctate lesions of DCN result in sparse degeneration that is also widespread in VPL. Structures which appear to be clusters of terminal arborizations of the ascending afferent input were also observed in VPL. These results suggest that somatotopy and modality separation in VPL may be determined either by intrinsic and/or corticothalamic morphological relationships and not by precise topographical ordering of sensory input.

Afferent Pathways↗
PubMed1980

Comparison of econazole and clotrimazole in the treatment of vulvovaginal candidiasis.

The therapeutic effectiveness of econazole and clotrimazole was evaluated in 178 women with clinical symptoms of vulvovaginal candidiasis and positive laboratory findings for Candida. The patients were randomly assigned to treatment with either 1% econazole vaginal cream or 100-mg clotrimazole vaginal tablets, each used once daily at bedtime for 7 days. The mycologic cure rates were comparable in the 2 treatment groups. There was a low incidence of local adverse reactions with both drugs.

Adolescent↗
PubMed1979

An evaluation of Corynebacterium parvum during remission maintenance therapy in pediatric patients with acute lymphoblastic leukemia.

The biologic impact and clinical toxicity of Corynebacterium parvum administered at a dose of 5 mg/M2 by intravenous or subcutaneous routes were evaluated in 18 children receiving combination chemotherapy for maintenance of acute lymphoblastic leukemia (ALL) in remission. Several nonspecific immunologic and hematologic parameters were evaluated. Patients were also monitored for changes in cutaneous sensitivity to histamine. No changes in any parameter were observed in patients after only one course of C parvum injection. However, after 6-10 courses, glass-adherent peripheral blood leukocytes of C parvum-treated patients augmented the response of PHA-stimulated autologous lymphocytes. In all nine patients studied who received C parvum injection subcutaneously for at least six months, there were significant increases in the mean bone marrow myelocyte-erythrocyte (ME) volumes compared to pretreatment values. These results suggest that periodic evaluations are desirable in patients receiving repeated administration of C parvum, since changes in immunologic and hematologic responses may be demonstrable only after several injections. In contrast to the reported experience in adults, subcutaneous C parvum administration children was not well tolerated, whereas intravenous infusion was generally well tolerated.

Acute Disease↗
PubMed1979

Heat-labile enterotoxin production in isolates from a shipboard outbreak of human diarrheal illness.

As reported elsewhere, an enterotoxigenic strain of Escherichia coli serotype O25:K98:NM was epidemiologically incriminated as the etiological agent in a shipboard outbreak of diarrheal illness. This enterotoxigenic E. coli strain and possibly other enteric isolates were found to produce heat-labile toxin and not heat-stable toxin. Since previous genetic analyses of enterotoxigenic E. coli strains producing heat-labile and heat-stable toxins have shown a plasmid location for both toxin determinants and since in this outbreak more than one bacterial strain appeared to produce only heat-labile toxin, the possibility of an extrachromosomal heat-labile toxin determinant was investigated. Results of endonuclease cleavage and hybridization experiments, as well as apparent heat-labile toxin phenotypic instability, strongly suggest a plasmid mediation of toxin production. Additionally, the stability of this heat-labile toxin production was evaluated after several traditional methods of bacterial cell preservation.

Bacterial Toxins↗
PubMed1979

Community health.

Explore the source record for details and available documents.

Community Health Services↗
PubMed1979

Autologous bone marrow transplantation in patients with cancer.

Ten patients with non-leukemic neoplasms received intensive, marrow-lethal doses of drugs and radiation followed by rescue with autologous cryopreserved bone marrow (nine) or marrow from an identical twin as part of a phase 1-2 study. Nine patients had extensive disease that was unresponsive to conventional therapy. Marrow engraftment was documented in all evaluable cases and most patients had a substantial anti-tumor response. Three patients are alive from 4 to 10 months following transplantation without evidence of disease.

Bone Marrow Transplantation↗
PubMed1977

Femoral neuropathy associated with anticoagulant therapy.

The English literature concerning femoral neuropathy associated with anticoagulant therapy is reviewed. Anatomical dissections were carried out in order to determine how the neuropathy might be produced. It is postulated that hemorrhage occurs within the iliacus muscle and that a pressure neuropathy of the femoral nerve ensues. Conservative management is recommended. The condition is probably more prevalent than previously thought, as evidenced by the fact that two cases were diagnosed in as many years by one orthopedic surgeon in a 300-bed general hospital.

Anticoagulants↗
PubMed1976

Mechanism of the interaction of propranolol and a potent vasodilator antihypertensive agent - minoxidil.

A study, using non-invasive techniques, was carried out in ten patients with essential hypertension to examine the mechanism of the hypotensive effect of propranolol when used in combination with a potent vasodilator antihypertensive - minoxidil. The hypotensive effect of minoxidil, a mean (+/- SEM) decrease of 42.4 +/- 4.3 mm Hg, was accompanied by a marked increase in heart rate, cardiac index and plasma renin activity and a significant decrease in total peripheral resistance, limb vascular resistance and pre-ejection period. Addition of propranolol further reduced mean arterial pressure by an average of 12.9 +/- 2.0 mm Hg. Propranolol returned cardiac index to control values and total peripheral resistance index rose but not to control levels. Plasma renin activity was significantly reduced by propranolol. By multiple regression analysis no correlation was found between propranolol-induced decrease in mean arterial pressure and changes in cardiac index, total peripheral resistance index or plasma renin activity. Quantitatively, the reduction in cardiac index observed probably accounted for the hypotensive effect of propranolol. The role of plasma renin activity reduction in the hypotensive effect of propranolol in this situation remains to be clarified. The findings in the present study were consonant with the known actions of vasodilator antihypertensive agents and propranolol and indicate the applicability of non-invasive methodology to the investigation of cardiovascular drugs in man.

Adult↗