PURPOSE: To test the hypothesis that nutritional status at diagnosis, defined as body mass index standard deviation score (SDS), is related to the prognosis in childhood acute lymphoblastic leukemia (ALL). PATIENTS AND METHODS: The sample consisted of 1,025 patients with standard risk ALL who had been randomized to different intensification therapies. Outcome measures were relapse/no relapse and time to first relapse. The influence of body mass index SDS was tested by survival analysis. RESULTS: There was no evidence that body mass index SDS was related to clinical outcome (proportional hazards model, p = 0.72). CONCLUSIONS: The study results suggest that nutritional status at diagnosis, defined on the basis of the body mass index, at least in developed countries, has no effect on the prognosis in ALL, and it should not be considered as a prognostic factor.

Adolescent↗

PubMedDate not supplied

A stream depletion field experiment.

A field experiment was carried out to measure drawdowns in observation wells and stream depletion flows that occurred when water was abstracted from a well beside a stream. The field data is analyzed herein to determine the aquifer transmissivity, T, the aquifer storage coefficient, S, and a streambed leakage parameter, lambda, by comparing measurements with a solution obtained by Hunt (1999). The analysis uses early time drawdowns with a match-point method to determine T and S, and stream depletion measurements at later times are used to determine lambda. The final results are reasonably consistent for measurements taken in four observation wells. The advantages and disadvantages of this approach are discussed, and two alternative ways of estimating lambda are also discussed.

Environmental Monitoring↗

PubMedDate not supplied

Radiological diagnosis and staging of primary bronchogenic carcinoma.

Bronchogenic carcinoma remains the commonest fatal malignancy worldwide. In this paper we discuss the various imaging modalities available to aid diagnosis and staging, presenting these techniques in a clinical sequence. We also consider some of their limitations.

Bone Neoplasms↗