Search PubMed⌕ Search

Biomedical subjects

J Weinstein

Publications and source records attributed to J Weinstein.

At least 109 records · Page 6Linked to original sources
PubMed1976

Selective N-actylation of gentamicin antibiotics-synthesis of 1-N-acyl derivatives.

Treatment of acid addition salts of aminoglycoside-aminocyclitol antibiotics of the gentamicin-sisomicin class, with one equivalent of triethylamine and an acylating agent results in selective formation of 1-N-acyl derivatives. This is in contrast to acylation of the antibiotic free bases which results in preferential acylation of other basic centres in the molecule. Origins of the observed selectivity are discussed. In vitro antibacterial activities of several new 1-N-acy1 derivatives of gentamicin, sisomicin and verdamicin are reported.

Acylation↗
PubMed1972

Receptors for histamine can be detected on the surface of selected leukocytes.

Histamine insolubilized by chemical linkage via a protein or polypeptide carrier to Sepharose beads cannot penetrate cells. Even so, the resultant histamine-coated Sepharose binds leukocytes selectively. Despite the low molecular weight of histaminie, the binding is via preformed cell membrane receptors and can be specifically and competitively blocked or reversed by antihistamines.

Agar↗