Search PubMed⌕ Search

Biomedical subjects

J Wedell

Publications and source records attributed to J Wedell.

At least 37 records · Page 2Linked to original sources
PubMed1983

[Use of Dukes' classification in rectal cancer].

An account is given of the historical development of various modifications of the Dukes classification. These modifications are rather different from the original classification. In some modifications the muscularis propria is falsely identified as muscularis mucosae. Therefore the term "modified Dukes classification" should be omitted, and should be replaced by a classification bearing the name of the respective author.

Humans↗
PubMed1983

[Does an obturation in colorectal cancer also modify the behavior of the serum CEA level?].

The CEA-plasma level was determined in 10 patients with malignant obstruction of the large intestine and in 6 patients with benign obstruction of the small intestine. The plasma carcinoembryonic antigen levels were obtained prior to initiating of the treatment and sequentially after treating the complete obstruction. Elevated plasma carcinoembryonic antigen levels are related to the carcinoembryonic antigen production by the primary tumour and not additionally to the obstruction. An elevated plasma CEA level in patients with benign obstruction could not be detected. After relief of obstruction, significant changes in the mean carcinoembryonic antigen values could not be observed.

Adenocarcinoma↗
PubMed1983

[Image of tumorous obstructions of the extrahepatic bile ducts in computer tomography].

Basing on a patient material consisting of 28 patients with tumours in the region of the extrahepatic bile ducts, the following criteria are examined which govern the demonstration of tumour obstructions by means of the computer tomogram: Extent of widening of the bile ducts, assessment of stenosis or complete obstruction of the bile ducts and demonstration of the structure of the tumorous tissue and of the tumorous infiltration into the adjacent tissues. Computerized tomography of this region can achieve a narrowing-down of the indications for an endoscopic or percutaneous visualization of the bile ducts, these being more severely invasive methods.

Bile Duct Neoplasms↗
PubMed1982

[Morbidity and mortality following intraperitoneal closure of transverse loop colostomy (author's transl)].

The postoperative course of 104 patients, who underwent closure of a transverse loop colostomy at the Surgical Department of the Teaching Hospital Herford between 1974 and 1980 after distal resection and anastomosis of the large bowel for neoplastic or diverticular disease has been reviewed in detail. The mortality was 0.9% and the morbidity rate was 25%, including 25% wound infections and 4.8% fecal fistulas. The highest complication rate was noted, when colostomies were closed during the first 6 weeks. Wound infections and fecal fistulae did not occur more frequently than in patients with diverticulitis. The intraperitoneal procedure of transverse loop colostomy closure can be recommended as to be straightforward and safe.

Adult↗
PubMed1982

[Leiomyoblastoma of the stomach (author's transl)].

Clinical symptomatology, pathology and surgical management of five patients with gastric leiomyoblastoma are reported. Leiomyoblastomas of the gastrointestinal tract are defined as a group of tumors, which originate from the smooth muscle, and which have to be classified in between benign leiomyomas and malignant leiomyosarcomas. These tumors metastasize in about 10% of cases. Patients come to the hospital in most cases because of unspecific upper abdominal symptoms. During surgery one usually finds solitary, well defined, cystic tumors of a size of 0.5 to 30 cm expanding intramurally versus neighbouring structures; ulcerations of the gastric mucosa are rare. The diagnosis is established by microscopic examination during surgery. Treatment is extensive excision of the tumor.

Adult↗
PubMed1981

[Abdominal trauma].

Extent and seriousness of an abdominal trauma can be defined in 4 clinical stages. Clinical stage IV is characterized by acute bleeding to death caused by injuries of the aorta, V. cava, liver- or hepatic veins. Clinical stage III includes haemorrhage caused by liver or spleen injury. The haemorrhage of the liver which cannot be controlled surgically indicates hepatic artery ligation. In clinical stage II injuries of the duodenum, pancreas and gastrointestinal tract are predominant and necessitate diagnostic procedures. Symptoms of shock prevail in clinical stage I frequently, there are no organ injuries. The midline abdominal incision with possible extension to median sternotomy or right thoracotomy remains the optimal approach.

Abdominal Injuries↗
PubMed1980

A new concept for the management of rectal prolapse.

The various modified fixation procedures used for rectal prolapse take into account the pathophysiologic concept of complete prolapse of the rectum as a sliding hernia of the pouch of Douglas. The possibility of intussusception by reinforcement of the wall of the extensively mobilized rectum was successfully prevented by a new technique. The use of this simple technique in another form of prolapse, namely, prolapse of the terminal colostomy, convinced us to its usefulness.

Humans↗
PubMed1980

[Local recurrence following anterior resection of rectal cancer. CEA-titer (author's transl)].

The records of 70 patients undergoing a curative anterior resection at the Surgical Department of the Academic Teaching Hospital in Herford for carcinoma of the rectum between January 1, 1974 and December 31, 1978 were reviewed. There were 6 cases (8,5%) developing suture line and local recurrence between 9 and 16.5 months after anterior resection. In this study a rising CEA-titer was the first evidence of recurrence in only 29% of our patients. Among 9 patients with confirmed local recurrence - 6 from our own and 3 from outside - only 2 (22%) showed an increase in CEA levels above normal. In the face of the poor 5-year survival with secondary abdomino-perineal resection following anterior resection one must ask if the significance of those operative procedures with their technical difficulty is justified. Our own experience of 9 patients with secondary abdominoperineal resection for local recurrence has changed our mind for a more palliative operative procedure in such cases.

Carcinoembryonic Antigen↗
PubMed1979

[Problems of sigmoid diverticulitis in the female and its differential diagnostic delineation from the left-sided adnexal tumor].

In the last three years 42 patients with complicated diverticulitis were treated surgically. There were 18 women in all. Nine of these women were believed to have gynecologic disease because of the palbable pelvic tumor and were hospitalized at the Gynecologic Department. 2 patients underwent an exploratory operation by gynecologic surgeons based upon preoperative diagnosis of ovarian mass. The diagnosis at operation in all two cases was perforated sigmoid diverticulitis. Another three of the nine patients had initally emergency exploratory operations by gynecologic surgeons based upon diagnosis of pelvic mass. Also here the diagnosis at operations were perforated sigmoid diverticulitis and they underwent emergency primary resection of the perforated sigmoid by surgeons. In all the cases of complicated diverticulitis the surgical proceature was the primary resection; the anterior resection was combined with a temporare transverse colostomy.--Diverticulitis is an important differential diagnosis of a left pelvic tumor in women with or without clinical and laboratory indications of infections and history of diverticulitis.

Adnexa Uteri↗
PubMed1978

[The potentiation of betazol stimulated gastric acidity by prednisolone in dogs (author's transl)].

In a total of 46 dogs divided into 5 groups the acute effect of a high dose of prednisolone (40 mg/kg i.v.) on betazol stimulated gastric seccretion (5mg/kh s.c.) was investigated. There was no effect of prednisolone alone. The combination of betazol and prednisolone showed a significant potentiation of betazol stimulation. This effect was not seen after truncal vagotomy before stimulation. The mechanism is either cholinergic or an interaction in the metabolism of histamine.

Animals↗
PubMed1977

[The demonstration of pharmacological active substances in the portal vein blood of dogs after occlusion of the superior mesenteric artery (author's transl)].

The experimental occlusion of the superior mesenteric artery in dogs is followed by a significant rise of serotonin-, kinin- and katecholamin-concentrations in the portal vein blood. The rise of the prostaglandin-F2alpha-concentration occurred only immediately after the occlusion or reopening of the occluded superior mesenteric artery. Under our experimental conditions the measured concentrations of these substances in the portal vein blood are too low and ineffective for the development of peptic erosions in the stomach as observed after occlusion of the superior mesenteric artery. On the other hand a possible additiv effect of the underswelling concentrations in these different substances cannot be excluded.

Animals↗
PubMed1977

[Utilization of the small intestine fistula technique in paralytic ileus. Report on clinical experience].

Seventy-three patients with paralytic ileus hospitalized at the Surgical Clinic of the Hospital in Herford during the years 1971-1975 are reviewed. All the patients were treated with a small bowel fistula according to a modified technique of Witzel-Heidenhain. The special indication, the technical details, and the results are discussed. The overall mortality of a total of 73 patients with paralytic ileus undergoing a small bowel fistula operation was 19%. The temporary small bowel fistula according to the modified technique of Witzel-Heidenhain is proposed as a simple, safe, and with accurate indication an effective method for accomplishing total decompression of distended bowel.

Adolescent↗
PubMed1977

[Eosinophilic granuloma of the gastrointestinal tract (author's transl)].

The eosinophilic granuloma of the intestine is a rare disease and is difficult to classify as far as etiology and pathogenesis are concerned. Unexplained, recurrent colicky obstipation and diarrhea accompained by anemia should induce x-ray examination of the small intestine and selective angiography in case of acute bleeding. Therapy with corticosteroids is justified in cases with diffuse involvement of the intestine without stenoses or ulcerations. Otherwise surgical removal of the involved segments with cure the disease, which is always benign.

Adrenal Cortex Hormones↗