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Biomedical subjects

J Weber

Publications and source records attributed to J Weber.

At least 667 records · Page 37Linked to original sources
PubMed1981

Central retinal arteries in the full-term newborn: decrease in width and tortuosity during uneventful adaptation.

The fundi of 87 full-term newborns were repeatedly photographed from 2 to 144 h of life. At 2 h of life the width of the temporal arteries in the peripapillary area was about 100 micrometers and that of the nasal arteries about 70 micrometers, and all gradually decreased by about 30% during uneventful adaptation in room air. This decrease did not correlate with concomitant tcpO2 and blood pressure measurements. In most babies the arteries were slightly tortuous at 2 h of life and gradually straightened during adaptation. In some babies, however, there was marked tortuosity at 2 h of life, and this finding was significantly correlated with fetal risk factors. We conclude that marked tortuosity is a sign of passed acute fetal distress and that funduscopy in risk babies should be promoted.

Blood Pressure↗
PubMed1981

[Thoracic surgery in patients older than 70 years (author's transl)].

In a total of 10,000 thoracosurgical operations the percentage of patients being older than 70 years amounted to 1.1. Most of these patients underwent surgery for bronchial carcinoma. The postoperative mortality rate in these patients could be lowered to 1.0% (1977/78). 25% of the patients older than 70 years who suffered from lung cancer stage I and II survived for more than 5 years after operation.

Age Factors↗
PubMed1980

A complication with the Gianturco coil and its non-surgical management.

During the placement of a Gianturco coil in a patient with renal cell carcinoma, the cotton threads of the steel coil remained fixed to the introducing catheter tip, and the coil was unintentionally withdrawn from the selected renal artery back into the aorta. By snare technique the coil was caught with another angiographic catheter and withdrawn successfully via the transfemoral route by aid of a coaxial catheter sheath. There were no complications.

Adenocarcinoma↗
PubMed1980

Occlusion arteriography: diagnostic and therapeutic applicability of balloon catheters.

Occlusion arteriography using flow-directed Swan-Ganz balloon catheters is a safe and simple method, which opens up new technical, diagnostic, and therapeutic possibilities. Since 1976, occlusion arteriography with double-lumen Swan-Ganz balloon catheters and a percutaneous introducer system has been performed in 315 patients. The following advantages were found: (1) simplification of selective and subselective catheterization due to the flow-directed positioning of the balloon-tipped catheter; (2) high contrast of the arterial phase of the angiogram and demonstration of the smallest arteries as a result of a brief, complete occlusion of the main vessels ("standstill arteriogram"); (3) early and optimal demonstration of the corresponding venous system, especially optimization of the indirect splenoportogram and mesentericoportogram; (4) reduction of the volume of contrast agent usually needed for diagnostic reasons; (5) reliable and complete blockade of the tumor-feeding artery during transcatheter embolization with particulate substances; (6) reliable and complete blockade of the feeding artery as a preoperative protective measure in tumor nephrectomy and splenectomy.

Angiography↗
PubMed1980

Plasma catecholamine levels and vascular response in deoxycorticosterone acetate hypertension of rats.

1. In rats with deoxycorticosterone acetate (DOCA) hypertension basal plasma concentrations of noradrenaline and adrenaline correspond to those of sham-treated controls. 2. In DOCA-treated rats frusemide caused a more pronounced increase in plasma noradrenaline than in control rats. This difference was not observed for adrenaline. 3. In the isolated perfused hind-limb preparation the sensitivity to noradrenaline was already enhanced before blood pressure was elevated. 4. These results suggest that the adrenergic vascular tone is increased in DOCA hypertension in rats.

Animals↗
PubMed1980

Ritodrine in the treatment of preterm labour. A clinical trial to compare a standard treatment with three regimens involving the use of ritodrine.

In a randomized trial, three alternative schemes of treatment of preterm labour with ritodrine (long infusion, short infusion, and intramuscular injection) were compared with standard treatment by bed rest and sedatives. None of the ritodrine treatments were found to be better in postponing delivery than the standard treatment. However, the Bishop scores of the patients in the standard treatment group tended to be lower than of the patients treated with ritodrine. Moreover, all cases of congenital malformation and polyhydramnios occurred in the patients treated with ritodrine. The incidence of respiratory insufficiency was significantly higher in infants of mothers treated with ritodrine. The mean birth weight was highest in the standard treatment group.

Adult↗
PubMed1980

Order of polyadenylic acid addition and splicing events in early adenovirus mRNA formation.

A study of the processing of mRNA from two early adenovirus type 2 transcription units (regions 2 and 4 of adenovirus type 2 genome; [J. Flint, Cell 10:153--166, 1977]) revealed that polyadenylic acid [poly(A)] was added in most if not all cases to an unspliced nuclear RNA molecule whose coordinates extended from the apparent initiation site for RNA synthesis to the single poly(A) site in each transcription unit. An intermediate RNA molecule in the processing of the mRNA for the 72,000-M, single-stranded DNA binding protein showed that the first of the two intervening sequences, the one closest to the 5' end of the molecule, was removed first at least in the majority of the processed molecules. Finally, in cells labeled for 10 min and then treated with actinomycin D to stop further RNA synthesis, the majority, if not all, of the poly(A)-terminated nuclear RNA specific for region 2 was successfully processed and transported to the cytoplasm.

Adenoviruses, Human↗
PubMed1980

Infectivity and uncoating of adenovirus cores.

A temperature-sensitive mutant of adenovirus type 2 grown at 39 degrees (tsl-39 degrees) produces noninfectious physical particles. DNA and core structures derived from such virion particles, however, were found to be infectious at the permissive temperature. Calcium chloride mediated transfection showed that core structures were 20-40 times more infectious than deprotenized DNA. Because in vivo the noninfectious ts1-39 degrees virions are blocked in uncoating at the core-like stage, we attempted to determine the reason for the infectivity of tsl-39 degrees cores prepared in vitro by investigating the metabolic fate of labeled cores in transfected cells. As opposed to infection with virus, the tsl-39 degrees cores were found to penetrate the nucleus efficiently and uncoat by shedding their core proteins. A possible explanation for the infectivity of the cores is discussed.

Adenoviruses, Human↗
PubMed1980

[Abdominal visceral occlusion arteriography. A study of technique and diagnostic results compared with the conventional catheter-assessed arteriography (author's transl)].

Since 1976, balloon occlusion arteriography has been performed for diagnostic and therapeutic reasons in about 300 patients. The technical procedure and the safety measure of using balloon catheters with a percutaneous introducer system are described. Compared with the conventional procedure of catheterization of the visceral abdominal arteries, the following advantages were seen in 103 examinations: 1. Simplification of selective and super-selective catheterization due to flow-directed positioning of the balloon tipped catheter in about two thirds of the cases; 2. High contrast in the arterial phase and superior demonstration of smallest arterial vessels in 94% of cases as a result of temporary shorttime complete balloon occlusion of the feeding artery ("standstill-arteriogram"); 3. Early and improved demonstration of the corresponding venous system. The indirect spleno- and mesentericoportogram was improved in 88% of cases; 4. Reduction of the amount of flow, contrast and film material--usually needed--by about 25%. Occlusion arteriography with balloon catheters is a safe and simple method bringing new technical and diagnostic aspects to selective and superselective angiography.

Angiography↗
PubMed1980

[Analysis and trends of treatment in cancer of the lung (author's transl)].

From 1953 to 1978 3439 patients suffering from bronchial carcinoma underwent operation. Due to the changing conditions of mass X-ray early detection of lung cancer decreased. This was followed by a declining number of operations but also by an increase in pneumonectomies (1974 to 1978). The average number of exploratory thoracotomies amounts now to 14% with increasing tendency, especially in patients younger than 50 years of age. Above 70 years lung resections are only possible in rare cases. The postoperative mortality rate (till 4 weeks after surgery) is now at 1,0%. After resection or pneumonectomy more than 40% of the patients will survive for 5 years. The authors recommend lung resection--if technically possible--also in a progredient state of the tumour.

Adult↗
PubMed1980

[Percutaneous removal of intravascular fragments from infusion, angiography and cerebrospinal fluid drainage catheters with the loop-snare technic].

Intravascular loss of catheter fragments (for infusion, angiographic, or CSF shunting purposes) represents a serious complication. There is a high morbidity rate and even mortality when the foreign body remains within the vascular system. Nonsurgical percutaneous removal of 16 catheter fragments from the venous side and 1 Gianturco coil from the abdominal aorta by use of a catheter sheath introducer system and the loop-snare technique is reported. If there is no local thrombosis, fragment recovery is relatively easy. Surgical intervention should be resorted to only when percutaneous removal turns out to be impossible.

Adolescent↗
PubMed1979

Protease of adenovirus type 2. Subcellular localization.

The subcellular localization of the adenovirus type 2 core polypeptide specific protease activity was investigated using an in vitro assay system. The protease activity was recovered exclusively from infected cell nuclei and was insoluble, sedimenting with the membrane fraction. Endogenous activity could be demonstrated in young virions which contain precursor PVII molecules. This protease activity only became sensitive to L-1-tosylamide-2-phenylethylchloromethyl ketone- or phenylmethylsulfonyl fluoride-mediated inhibition after disruption of the virus particles by sonication, suggesting that the enzyme was internally located. The putative precursors to virus particles, referred to as top components, which do not contain a full complement of viral DNA, did not contain protease activity. The protease released from sonicated virions converted exogenous PVII substrate molecules to polypeptide VII. The noninfectious H2ts1 virus particles synthesized at the nonpermissive temperature phenotypically resemble young virions, but unlike their wild type counterparts, were devoid of protease activity. The results show that the protease enters the precursor particles concurrently with the viral chromosome and that its presence is a prerequisite for the processing and subsequent maturation of infectious adenovirions.

Adenoviridae↗