Search PubMed⌕ Search

Biomedical subjects

J Watt

Publications and source records attributed to J Watt.

At least 73 records · Page 4Linked to original sources
PubMed1986

A prospective study of inhibitive casting as an adjunct to physiotherapy for cerebral-palsied children.

The effect of a three-week course of inhibitive casting and neurodevelopmental therapy on the static muscle tonus, developmental skills, passive range of ankle dorsiflexion and gait pattern was determined in 32 cerebral-palsied children. Two weeks after treatment, passive range of ankle dorsiflexion and foot-floor contact in walking had improved significantly but there was no significant change in the static muscle tone or developmental skills. After five months the improvements in ankle dorsiflexion and walking pattern were no longer evident. Further objective studies to determine the effect of 'inhibitive casting' are necessary before the modality is used indiscriminately.

Ankle↗
PubMed1986

Terfenadine and brompheniramine maleate in urticaria and dermographism.

The effects of brompheniramine maleate (12 mg twice daily in sustained release form) and terfenadine (60 mg twice daily) on the symptoms and well-being of 16 adults with urticaria with or without dermographism were assessed by symptom questionnaire. Following an initial 2-week period without therapy, each drug was taken for 2 weeks in a randomised double-blind cross-over study. Both drugs produced significant relief of itch and rash but only brompheniramine produced significant drowsiness. Brompheniramine maleate was more effective than terfenadine in the patients with dermographism.

Adult↗
PubMed1985

Autoradiographic localization of kappa opiate receptors in CNS taste and feeding areas.

Recent evidence suggests that kappa opiate receptors may play a key role in the regulation of appetite. Such evidence implies that kappa receptors might be localized within specific brain areas known to regulate ingestive behaviors. On the basis of this implication we employed an in vitro film autoradiographic technique using 3H-ethylketocyclazozine as ligand to identify putative kappa receptors within CNS "taste" nuclei and surrounding areas. Coronal cryostat sections of rat brain were incubated with ligand in the presence of D-Ala2, D-Leu5-enkephalin (DADLE) and morphine, apposed to LKB Ultrofilm for 60 days, processed and kappa receptor densities evaluated with the aid of a hand held photometer and video image analyzer. Highest kappa receptor densities were found within various gustatory and feeding sites including the rostral pole of the nucleus of the solitary tract, parabrachial nuclei, ventral posterior and medial portions of the thalamus, medial hypothalamus, medial nuclei of the amygdala and bed nucleus of the stria terminalis. Various other midline and medial limbic areas also showed significant kappa densities.

Animals↗
PubMed1985

Mother-infant interactions at 2 and 3 months in preterm, small-for-gestational-age, and full-term infants; their relationship with cognitive development at 4 months.

Two- and 3-month interactions were observed and 4-month Bayley MDI assessments carried out with 10 full-term, 14 preterm, and 9 small-for-gestational age (SGA) mother-infant dyads, to examine effects of neonatal status on interaction styles and the relationships between interaction variables and MDI scores. Two-month interaction patterns were most closely related to 4-month MDI scores in the full-term group, with state variables showing negative relationships and dyadic synchrony being positively related. For the preterm group, state-related variables were important to MDI scores. Preterm maternal interactive levels dropped from two to three months whereas preterm infant interactive levels rose from 2 to 3 months. SGA infant smile and maternal affection were related to MDI scores. SGA dyads differed from full-term dyads on state and synchrony variables. Findings are discussed with respect to the importance of state variables for development.

Adult↗
PubMed1984

Doctors in the wars.

Explore the source record for details and available documents.

History, 15th Century↗
PubMed1982

Loperamide modifies Escherichia coli, heat-stable enterotoxin-induced intestinal secretion.

We have shown previously that loperamide, an opiate analogue, inhibits cholera-toxin- and prostaglandin E2-induced secretion in the rat small intestine. In these studies loperamide modified secretion induced by partially purified Escherichia coli, heat-stable enterotoxin in infant mice. The drug was effective whether administered before or after established secretion. These experiments provide further suggestive evidence that loperamide has a broad spectrum of antisecretory activity.

Animals↗
PubMed1981

Excessive requirement for heparin during cardiac surgery.

A case of excessive heparin requirement during cardiopulmonary bypass is reported. A patient with sepsis secondary to a myocardial abscess require 13.5 mg x kg-1 of heparin to increase his activated coagulation time to a therapeutic level. This phenomenon might be due to individual variability, lupus vasculitis, septicaemia, repeated thromboembolic phenomenon with hypercoagulable state, or chronic disseminated intravascular coagulation with partial antithrombin deficiency.

Aged↗
PubMed1981

Path analysis: a strategy for investigating multivariate causal relationships in communication disorders.

This tutorial paper explains, illustrates, and discusses path analysis, a powerful strategy for examining the plausibility and degree of causal relationships which are postulated to exist among a set of variables. In addition to its strength as a method of theory testing, path analysis is highly compatible with the kind of retrospective research which is so often used to study speech and language pathologies. One of its major advantages is that it allows explicit recognition of multiple, interacting causes of communication disorders and allows the researcher to evaluate the logical consequences of assumptions made about the specific nature of those causal relationships. A summary of the meaning of causal relationships is followed by a presentation of the principles underlying path analysis, as well as an outline of its basic procedures. Also presented is an illustrative example of the application of path analysis to the evaluation of some competing causal theories of a communication disorder. Finally, the general advantages of path analysis and its applicability to the investigation of causal relationships in speech and language pathologies are summarized and discussed.

Humans↗
PubMed1981

Harmful effects of carrageenan fed to animals.

An increased number of reports have appeared in the literature describing the harmful effects of degraded and undegraded carrageenan supplied to several animal species in their diet or drinking fluid. The harmful effects include foetal toxicity, teratogenicity, birth defects, pulmonary lesions, hepatomegaly, prolonged storage in Kupffer cells, ulcerative disease of the large bowel with hyperplastic, metaplastic, and polypoidal mucosal changes, enhancement of neoplasia by carcinogens, and, more ominously, colorectal carcinoma. Degraded carrageenan as a drug or food additive has been restricted in the United States by the FDA, but undegraded carrageenan is still widely used throughout the world as a food additive. Its harmful effects in animals are almost certainly associated with its degradation during passage through the gastrointestinal tract. There is a need for extreme caution in the use of carrageenan or carrageenan-like products as food additives in our diet, and particularly in slimming recipes.

Animals↗