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Biomedical subjects

J Watt

Publications and source records attributed to J Watt.

At least 19 recordsLinked to original sources
PubMed1992

The pre-ulcerative phase of carrageenan-induced colonic ulceration in the guinea-pig.

The pre-ulcerative phase of carrageenan-induced colonic ulceration was investigated in guinea-pigs supplied 3% degraded carrageenan as an aqueous solution as drinking fluid for 2 or 3 days during which no ulceration of the bowel was observed with the naked eye or dissecting microscope. Mucosal microscopic changes, from caecum to rectum, were multifocal and included cellular infiltrates, dilatation of glands, crypt abscesses, micro-ulcers and sulphated polysaccharide in the lamina propria. Sulphated polysaccharide was also demonstrated histologically for the first time within the surface epithelium and showed ultrastructural features similar to carrageenan. The results indicate that colonic epithelium in the guinea-pig is capable of macromolecular absorption. Carrageenan, a highly active polyanionic electrolyte, within the surface epithelial cells is most likely a primary factor in the breakdown of mucosal integrity. Macromolecular absorption causing enteropathy of the large bowel is a new pathophysiological concept which may have implications in man, particularly in the pathology of large bowel disease.

Animals↗
PubMed1989

Rapid production of ulcerative disease of the colon in newly-weaned guinea-pigs by degraded carrageenan.

In a dose-response study, degraded carrageenan (Eucheuma spinosum) was supplied in the drinking fluid at 1.2 and 3% concentrations over two weeks to young adult guinea-pigs. Ulceration of the large bowel was produced in 100% of animals, the severity and extent of damage probably being dose-related. In a time-course study, 3% degraded carrageenan solution supplied to newly-weaned guinea-pigs produced in 100% of animals ulceration in the caecum by four days and in the ascending colon by seven days. The onset of ulceration occurred as early as the second day. This model is convenient and economic for the screening of drugs of potential therapeutic value in human ulcerative colitis.

Animals↗
PubMed1989

Postprandial motor response of the small intestine to enteral feeds in preterm infants.

The postprandial motor response to enteral feeds of the small intestine of preterm infants is dependent on the bolus volume of feed that the infants receive and the number of days over which enteral feeds have been given. The postconceptional age of the infant is not an important determinant. The early introduction of enteral nutrition to preterm infants is therefore likely to enhance the motor response of the small intestine to feeds.

Action Potentials↗
PubMed1977

Ischemic colitis associated with carcinoma of the colon.

Two cases of ischemic colitis occurring proximal to carcinoma of the colon are described, with special reference to the barium enema and pathological findings. The association of these two conditions is rare but when present may cause some confusion. It is possible that the two lesions may, for instance, be considered to be both due to ischemic colitis, or mistaken for granulomatous colitis with a stricture.

Aged↗
PubMed1977

Benign parotid swellings: a review.

The one common factor associated with the innumerable causes of benign parotid enlargement is xerostomia which influences the quantity and quality of parotid secretion and thus paves the way for duct obstruction and pyogenic infection.

Bacterial Infections↗