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Biomedical subjects

J Watine

Publications and source records attributed to J Watine.

At least 55 records · Page 3Linked to original sources
PubMed1997

Epidemiologically related and unrelated strains of Pseudomonas aeruginosa serotype O12 cannot be distinguished by phenotypic and genotypic typing.

A clonal origin for European isolates of antibiotic multi-resistant Pseudomonas aeruginosa serotype O12 has been suggested. This study was designed to assess the value and limitations of several typing methods for the investigation of outbreaks due to this serotype. In Hôpital de Rodez, France, this organism is endemic, and a prospective clinical epidemiological study was undertaken over a 15 month period, encompassing all patients at the hospital from whom P. aeruginosa O12 was isolated. All isolates were examined by auxanogram, antibiogram, phage-typing, electrophoresis of esterases and pulsed-field gel electrophoresis of DNA. The results suggest that (1) the methods used did not clearly differentiate between clinically-related and epidemiologically-unrelated European isolates, (2) in Hôpital de Rodez, while some isolates were likely to have been transmitted from patient-to-patient, most infections or colonizations with this organism were sporadic and their origin is unknown. The limits of typing methods for the investigation of outbreaks of nosocomial infection with multi-resistant P. aeruginosa O12 are emphasized.

Aged↗
PubMed1997

[Bactericidal activity of quinolones (including sparfloxacin) against Enterococcus; in vitro antagonisms with gentamicin].

We selected 20 clinical Enterococcus isolates in order to represent the different types of amoxicillin and/or gentamicin-resistance present in our hospital. Bacteriostatic and bactericidal activities of amoxicillin, pefloxacin, ofloxacin, ciprofloxacin, sparfloxacin, vancomycin, alone or associated with gentamicin, were evaluated on those 20 isolates. Sparfloxacin or ciprofloxacin were more frequently bacteriostatic and/or bactericidal than pefloxacin or ofloxacin. The effect of quinolones and gentamicin in combination use was not only synergistic but antagonistic, which is not in agreement with others' results.

Anti-Infective Agents↗
PubMed1996

Usefulness of a computerized expert system associated with systematic O-serotyping for the early detection of outbreaks of hospital acquired infections and for the presumptive antibiotic therapy of Pseudomonas aeruginosa infections.

Over a four-year period, the systematic O-serotyping of all Pseudomonas aeruginosa isolated in Hôpital de Rodez associated with the use of a computerized expert system, facilitated the early detection of two outbreaks of nosocomial infections with multiresistant serotype O:11 and multiresistant serotype O:12 P. aeruginosa respectively involving ten patients over 16 months and six patients over six months. Over this four-year period, serotype O:12 represented 14% of 404 clinical isolates of P. aeruginosa, and most isolates of this serotype were resistant to multiple antibiotics. Combination experiments showed that fosfomycin/amikacin together were active against 86% of O:12 isolates. Fosfomycin/amikacin might be considered as a therapeutic alternative to ceftazime/amikacin for the presumptive antipseudomonal therapy of serotype O:12 infections.

4-Quinolones↗
PubMed1995

In vivo pefloxacin-resistant Campylobacter fetus responsible for gastro-intestinal infection and bacteremia associated with arthritis of the hip.

The authors report a case of Campylobacter fetus subsp. fetus gastro-intestinal infection and bacteremia with poly-arthritis, mainly of the hip, in a French patient simultaneously suffering from cirrhosis of the liver. The outcome was eventually favorable, however only after a trial of ineffective pefloxacin-gentamicin therapy. The authors suggest: (i) gentamicin should not be given alone in C. fetus subsp. fetus infections, and (ii) pefloxacin should not be given if antibiotic sensitivities data are not available. The inconclusive reliability of disk diffusion tests for C. fetus subsp. fetus should be recognized.

Arthritis, Infectious↗
PubMed1995

[Orosomucoid prealbumin ratio in bronchopulmonary cancers].

Lung cancer is a common pathology with high mortality due to late diagnosis. The 1987 TNM classification clearly defines the different steps and their prognosis. Although the prognostic value of some biological parameters (mainly serum LDH, sodium and/or albumin) has been established, these are not much used. We have prospectively studied the serum levels of seven proteins (RBP, prealbumin, albumin, transferrin, haptoglobin, orosomucoid, CRP) and we demonstrate the predominant value of prealbumin for the establishment of the prognosis of lung cancer; determination of orosomucoid increases the prognostic value of prealbumin. We confirm, for lung cancer, the prognostic value of the orosomucoid-prealbumin ratio, already known for other cancers.

Adult↗
PubMed1994

Susceptibility of multiresistant serotype 012 Pseudomonas aeruginosa to fosfomycin in combination with other antibiotics.

Serotype 012 represented 15% of 244 isolates of Pseudomonas aeruginosa isolated in the hospital over a 2 year-period and most isolates of this serotype were resistant to multiple antibiotics. Combination experiments showed that fosfomycin and amikacin together were active against 92% of 012 isolates. It is recommended that serotyping be used systematically to identify 012 strains rapidly and fosfomycin/amikacin be considered as a presumptive antipseudomonal therapy in 012 infections.

4-Quinolones↗
PubMed1992

Clostridium perfringens septicemia during the course of leukemia.

Clostridium perfringens (CP) is an infrequent cause of septicemia in neutropenic patients. We report the case of a 17 year old man treated for acute lymphoblastic leukaemia in whom a strain of CP was isolated from blood cultures. The clinical spectrum and evolution of CP septicemia in neutropenic patients are discussed.

Adolescent↗
PubMedDate not supplied

[Hemolyzed samples].

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Blood Specimen Collection↗