Biomedical subjects

J Warner

Publications and source records attributed to J Warner.

At least 145 records · Page 8Linked to original sources

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Surgical clip as a nidus for common bile duct stone formation and successful endoscopic therapy.

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Adult↗

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Plant antimutagenic agents, 2. Flavonoids.

A number of known prenylated flavonoids were isolated from Psoralea corylifolia using an assay procedure based on inhibition of the mutagenic action of 2-aminoanthracene on Salmonella typhimurium (T-98). All of these compounds were toxic rather than antimutagenic or desmutagenic. Bakuchiol [17], a known prenylated phenolic terpene, was also isolated; its activity was not due to toxicity. Biochanin A [4], a known isoflavone, was similarly isolated from Cicer arientinum and was active and nontoxic. Some of the above flavonoids were studied for inhibition of the mutagenicity of several different mutagens with results depending upon the structure of the flavonoid and the mutagen.

Anthracenes↗

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Plant antimutagenic agents, 3. Coumarins.

Several coumarins were isolated from crude plant extracts by means of an antimutagenic assay procedure. These coumarins included psoralen from Psoralea corylifolia and imperatorin and osthol from Selinum monniere. Studies of structure-activity relationships of these and several other available coumarins were carried out with four mutagens. All of the coumarins were nontoxic and in particular showed high activity in the inhibition of the mutagenicity of benzo[a]pyrene.

Benzo(a)pyrene↗

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Plant antimutagenic agents, 5. Isolation and structure of two new isoflavones, fremontin and fremontone from Psorothamnus fremontii.

Two new isoflavones, fremontin and fremontone, were isolated from roots of Psorothamnus fremontii (Fabaceae), a desert plant. Compound 1 has the structure 5'-(alpha, alpha-dimethylallyl)-5,7,2',4'-tetrahydroxyisoflavone; compound 2 is similar but also contains the 3'-(gamma,gamma-dimethylallyl) substituent. The alpha,alpha-dimethylallyl substituent is rarely observed, and the combination of the alpha,alpha- and gamma,gamma-dimethylallyl substituents is unprecedented. Both 1 and 2 were nontoxic toward Salmonella typhimurium and were both highly active in the inhibition of mutagenicity of ethyl methanesulfonate (EMS) at all concentrations tested. Compound 2 was more active than 1 in the inhibition of mutagenicity of 2-aminoanthracene (2AN) and acetylaminofluorene (AAF) toward S. typhimurium.

Animals↗

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Arthroscopic and histologic analysis of human patellar tendon autografts used for anterior cruciate ligament reconstruction.

To evaluate the fate of patellar tendon autografts in humans, the knees of 23 patients who had undergone anterior cruciate ligament reconstruction were examined 3 weeks to 6.5 years postoperatively. Arthroscopy and biopsy were performed on all patients. The patellar tendon autografts progressed through four stages of ligamentization after reconstruction. The first stage of repopulation occurred during the first 2 months and was evidenced by a viable 3-week specimen with an increasing fibroblast number and active nuclear morphology. Over the next 10 months, the graft went through a stage of rapid remodeling in which the fibroblast count increased markedly, the active nuclear morphology and neovascularity remained increased, and more areas of degeneration were present as the percentage of mature collagen decreased. The third stage or "maturation" stage occurred over the next 2 years and was characterized by a slow decline in the nuclei and the maturation of the collagen matrix. By 3 years the grafts were ligamentous by all histologic criteria examined. The authors conclude that human autogenous patellar tendon grafts are viable as early as 3 weeks postoperatively and may not go through a necrotic stage. They then progress through a prolonged process of ligamentization that takes as long as 3 years to complete.

Anterior Cruciate Ligament↗

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Nursing physical assessment skills: implications for UK practice.

The physical assessment skills of inspection, palpation, percussion and auscultation currently have only minimal recognition in UK nursing practice. Authors attest to perceived benefits in terms of continuity of care, holistic care delivery, rapidity of emergency intervention and reduction in junior doctors' hours and workload. However, the use of such skills by nurses has been subject to little in the way of formal outcome-based evaluation, and there is a clear need for such research to be carried out within the UK. Important guidelines exist within the literature to underpin educational programmes in physical assessment; these are reviewed and their implications for UK practice are considered. It is concluded that while generation of a UK evidence base is required, there is a persuasive argument to underpin continued development of physical assessment skills within UK nursing practice.

Clinical Competence↗

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