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Biomedical subjects

J Wallin

Publications and source records attributed to J Wallin.

At least 73 records · Page 4Linked to original sources
PubMed1982

Rapid typing of herpes simplex virus based on immunological specificity of viral thymidine kinase and typing according to sensitivity to iododeoxyuridine.

We describe two methods for typing of herpes simplex virus (HSV). One procedure is based on the finding that the multiplication of HSV type 1 strains in primary rabbit kidney cells is inhibited by 2 x 10(-5) M iododeoxyuridine, whereas growth of HSV type 2 strains is considerably less affected. Forty-nine different HSV isolates were typed according to this method. For all isolates except two the results were found to be in agreement with results obtained by another typing procedure, the counterimmunoelectroosmophoretic method (S. Jeansson, Appl. Microbiol. 24:96-100, 1972). One HSV type 1 isolate behaved as a type 2 strain and was found to be a deoxythymidine kinase-negative mutant strain. The other deviant strain exhibited an intermediate iododeoxyuridine sensitivity, thus being impossible to type with this method. Another, faster typing procedure which is based on the immunological difference between HSV type 1 and 2 deoxythymidine kinase is also presented. This assay, in combination with the conventional methods for isolation, enables the detection of deoxythymidine kinase-negative therapy-resistant HSV strains. Finally, we report the detection and typing of HSV deoxythymidine kinase present in vesicle fluids.

Animals↗
PubMed1982

Coronary angiography with Iopamidol.

Iopamidol, a new non-ionic contrast medium with low osmolality, was compared with Isopaque Coronar during selective coronary angiography in 16 patients. Iopamidol caused significantly less bradycardia, less ECG changes and less fall in blood pressure than Isopaque Coronar. No subjective adverse effects such as chest pain, vomiting, nausea or sensation of heat occurred. The results indicate that Iopamidol has advantages as a contrast medium for coronary angiography.

Adult↗
PubMed1982

Urethritis in men.

This presentation provides an overview of urethritis in men, touching on its diagnosis, clinical manifestations, epidemiology, and treatment. In men presenting with signs and symptoms of urethritis, the importance of obtaining information as to the patient's sexual contacts is stressed. Methods for obtaining smears and culture samples are discussed, with special reference to the importance of differentiating between gonococcal and nongonococcal urethritis (NGU). The entity postgonococcal urethritis (PGU) in most instances represents cases of NGU, coincidentally acquired with gonorrhea. NGU accounts for more than half of cases of urethritis in men in several countries. Chlamydia trachomatis is isolated significantly more often in men with NGU than in control groups.

Chlamydia Infections↗
PubMed1981

Detection of adverse drug reactions in a clinical trial using two types of questioning.

Two methods of assessing adverse drug effects-an open-ended question versus a checklist-were compared in a clinical study involving 515 patients being treated with bacampicillin for gonorrhea. Results indicate that adverse reactions are reported more frequently if a checklist is used. However, it was also observed that more serious side effects are usually reported in response to an open-ended question rather than a checklist. Thus it was concluded that the optimal procedure for assessing adverse reactions is to record responses to both an open-ended question and a checklist.

Ampicillin↗
PubMed1980

The diagnosis of atrial myxomas. Difficulties and pitfalls.

Altogether seven patients with the preoperative diagnosis of atrial myxoma were admitted to our hospital in 1968-78 and referred for surgery. In two patients no tumour was found at operation. In one of them the reason for the misinterpretation was severely malformed mitral leaflets. In the other the contrast medium was injected into a pulmonary vein, which caused a contrast defect due to inadequate mixing.

Adult↗
PubMed1980

[Sexually communicable diseases: current status in Sweden].

In Sweden there are strict laws that traditional venereal diseases must be reported. In the years 1950-1978 only very few cases of syphilis were registered. The rate of gonorrhea increased from 1959-1970 and then there was a marked decrease. Possible reasons for these changes are discussed. In 7% of all men and 9% of all women with genital gonorrhea gonococci were found in the tonsillar region. Seventeen asymptomatic patients were followed without treatment; after 12 weeks all were culture-negative. The percentage of patients with non-gonococcal urethritis remained the same for the years 1972-1976. In 25% of these patients chlamydial infections could be detected. In women with acute salpingitis chlamydia were isolated in 36%.

Adolescent↗
PubMed1979

A dose response study with bacampicillin in uncomplicated gonorrhoea.

In a systematic study of dose-response relationship 883 patients with uncomplicated gonorrhoea were given single oral doses of 400, 800 or 1600 mg bacampicillin, with 1 g probenecid. A single dose of bacampicillin 800 mg plus probenecid was the minimum effective dose in patients with fully ampicillin-sensitive strains. In patients with gonococci showing reduced sensitivity to ampicillin, 1600 mg bacampicillin was required to reach a cure rate above 95%. Bacampicillin was well tolerated in all treatment groups. Side-effects were reported in 4.6% of the courses of treatment. The most frequent adverse reaction was loose stools (1.9%), which was noted more often after the 1600 mg dose but was considered to be of no or very little clinical importance.

Administration, Oral↗
PubMed1978

Myocardial infarction among men below age 40.

Studies were made in Göteborg over a period of 6 years of all cases of acute myocardial infarction diagnosed among men below the age of 40. Thirty-six cases were registered and 8 of these died outside hospital. Three patients died early during the hospital stay. The remaining 25 patients were compared with a random sample from the general population in Göteborg with respect to conventional risk factors. Smoking, and high plasma cholesterol values were dominating findings among the patients, whereas there was no significant differences in blood pressure levels. Coronary angiography was performed in 18 patients of whom 2 showed normal coronary arteries and left ventricular angiograms. These 2 patients were the only ones free from risk factors. Of the remaining 16 patients, 10 had only one vessel affected.

Adult↗
PubMed1978

Genital occurrence of oral microbiota.

Recent studies indicate that tonsillar gonococcal infection or colonization is fairly common. Carriage rates of about 8% have been found. These studies also indicate that oro-genital contacts are common. Since very little is known about the amount of oral microbiota transmitted to the genitals, we have studied the occurrence of oral streptococci and Neisseria species in urethra and cervix. Among 128 patients attending an STD-clinic we found 10 carriers of oral streptococci, one Streptococcus mitior, four Streptococcus sanguis, one Streptococcus mutans and four Streptococcus salivarius and case of urethritis due to Neisseria menigitidis. Seventy-three of the patients had recently had their genitals exposed to the oral flora of their partners. Despite the heavy contamination with oral microbiota that can be assumed to occur in these cases, there seems to be no colonization of the genitals with oral microbiota.

Adult↗
PubMed1977

5-Fluorouracil in the treatment of penile and urethral condylomata acuminata.

5-Fluorouracil (5-FU) cream was compared with podophyllin 25 percent in alcohol for treating genital and urethral condylomata acuminata. The cure rate after four weeks was found to be 6 of 18 patients treated with 5-FU and 10 of 19 treated with podophyllin. By changing the treatment for those not cured, warts regressed after four weeks in four more patients in each group. Patients were followed up for four to nine months; 10 of 27 treated with 5-FU and 14 of 31 treated with podophyllin remained in remission. It is not possible to support earlier reports on the successful treatment of meatal warts using 5-FU cream. More than half of the patients given 5-FU reported side effects after 10 to 14 days' treatment, which in some cases led them to stop using the cream. Twenty-one men considered to be treatment failures or relapses were examined by urethroscopy. No intraurethral condylomata were found but three cases of warts in the fossa navicularis were doscovered; this prompted us to introduce an instrument to examine the urethral meatus and the fossa navicularis.

Condylomata Acuminata↗
PubMed1977

The possible role of anaerobic bacteria in the aetiology of non-gonococcal urethritis in men.

Men with non-gonococcal urethritis (NGU) were divided into two groups and treated with either lymecycline or tinidazole; anaerobic cultures were performed before and after treatment. Neither treatment affected the anaerobic flora. However, the men treated with lymecycline were relieved of symptoms and signs, while those treated with tinidazole were not. The anaerobic bacteria found are considered normal inhabitants of the urethral tract and without significance in the aetiology of NGU.

Adult↗