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Biomedical subjects

J Walecki

Publications and source records attributed to J Walecki.

At least 91 records · Page 5Linked to original sources
PubMedDate not supplied

Renal artery resistance index, thyroid hormones, and thyroid volume in the early kidney transplants recipients.

BACKGROUND: Thyroid hormones could affect renal function, and, on the other hand, renal dysfunction may affect thyroid function. Disturbances of concentrations of thyroid hormones are often associated with thyroid gland enlargement. The aim of the study was to assess the function and morphology of the thyroid (volume and hormones concentration) and kidney function after transplantation (creatinine concentration and resistance index [RI] of transplant artery). MATERIAL AND METHODS: The group included 13 females, 19 males; aged 19-69 years, mean 44.75 +/- 14.8 years after transplantation with stable graft function. Thyroid volume, renal artery RI, creatinine concentration, and concentrations of T3, rT3, FT3, FT4, and TSH were estimated the day before surgery, and at 1, 3, 6, and 10 days after transplantation. RESULTS: The statistical analysis revealed a negative correlation between delta RI (difference between RI at 3 and 6 days after transplantation) and serum creatinine concentration, 10 days after transplantation (r = -0.63; P < 0.01). We also observed a negative correlation between creatinine serum concentration at 10 days after transplantation and delta thyroid volume (Delta Vol; r = - 0.48; p < .05), a positive correlation between delta FT4 (Delta FT4) serum concentration, and delta creatinine (Delta Crea; r = 0.73; P < .001). CONCLUSIONS: The dynamics of RI changes in the transplant kidney artery between 3 and 6 days after transplantation may predict graft function. Together with improved kidney function at 10 days after transplantation, we observed a regression of goiter.

Adult↗
PubMedDate not supplied

[The usefulness of the method of planar diffusion echo imaging (EPI DWI) in the diagnosis of cerebral ischemia].

The preliminary results of MR echoplanar diffusion-weighted imaging (EPI DWI) in patients with stroke are presented. Twelve patients (5 females, 7 males) aged 36-78 years (mean 63.8) were examined by 2T system. No focal lesions were found in the acute phase of stroke on T1-weighted images. Narrowing of sulci in the region of stroke was the only abnormal finding. Focal hyperintense lesions were shown on PD and T2-weighted images in 50% of patients in the acute phase, 7 hours after the onset of clinical symptoms. On EPI diffusion-weighted images focal decrease of apparent diffusion coefficient (ADC) was observed in all cases of the acute phase of stroke after 3 hours. EPI DWI allows for earliest detection of ischaemic lesions in brain tissue. The method is especially useful in characterisation of the acute phase of stroke and shows its evolution thanks to the use of ADC.

Acute Disease↗
PubMedDate not supplied

[Intervertebral discitis caused by staphylococcal sepsis].

The aim of the study was to present the intervertebral discitis of L5-S1 region and adjoining vertebrae in the course of staphylococcal sepsis. A 51-year-old man was treated in hospital because of sudden very strong pain in a lumbar-sacral region of spine with irradiation towards both legs. The patient had general symptoms of infection. The diagnosis of intervertebral discitis of L5-S1 region was made on the basis of magnetic resonance imaging and computed tomography. In case of radicular symptoms accompanied by very strong back pain, intervertebral discitis should be considered during diagnostic investigation.

Discitis↗
PubMedDate not supplied

MR proton spectroscopy in patients with CNS involvement in Bourneville's disease.

BACKGROUND: Despite much previous research, the origin of intracranial lesions in tuberous sclerosis is still unknown. We present MR and proton magnetic resonance (1H-MRS) studies of two patients with tuberous sclerosis. MATERIAL AND METHODS: The study material consisted of MR and 1H-MRS examinations from 2 patients (4-5 years old) with tuberous sclerosis. MR images (FSE, FAST, FLAIR) were obtained with a 1.5 T unit. Localized 1H-MRS studies (PRESS 35, TE 35 ms, TR 1500 ms, NEX 192) on cortical (n=3) and subependymal (n=1) lesions were also performed. RESULTS: Decreased N-acatyloaspartate/creatine (NAA/Cr) and increased myoinositol/creatine (mI/Cr) ratios were observed in the spectra obtained from the subcortical and subependymal tubers. CONCLUSIONS: Our observations confirm the hypothesis that disturbances of migration, adhesion and differentiation of germ neuronal cells may underlay the pathogenesis of tuberous sclerosis.

Central Nervous System Diseases↗
PubMedDate not supplied

Percutaneous fine-needle pancreatic pseudocyst puncture guided by three-dimensional sonography.

BACKGROUND/AIMS: At present a pancreatic pseudocyst puncture guided by ultrasonography is a treatment of choice in the majority of hospitals. A classical two-dimensional sonography is usually implemented in these cases. However, its shortcomings, mainly in differential diagnosis, are acknowledged by most physicians. The real time monitoring of a fine-needle pseudocyst procedure by two-dimensional ultrasonography is of questionable reliability. In our study we evaluated the usefulness of three-dimensional sonography in the percutaneous fine-needle pancreatic pseudocyst puncture. METHODOLOGY: We examined fifty-two patients diagnosed as having pancreatic pseudocysts on the basis of clinical symptoms and two-dimensional ultrasonography findings. Then the decision to qualify certain patients for the percutaneous fine-needle aspiration guided by ultrasonography was made on the basis of two- and three-dimensional scan results. The next step in our investigation was to implement color Doppler in order to visualize all blood vessels at the planned biopsy site. Three-dimensional sonography was used to monitor the tip of the needle making its way to the pancreatic pseudocyst and later inside the fluid collection. RESULTS: Pancreatic pseudocysts were diagnosed in all of the 52 cases. Three-dimensional sonography was more precise in visualizing the shape and size than two-dimensional ultrasound scans. CONCLUSIONS: Three-dimensional presentation can better visualize irregular shapes, local thickenings, and calcification of pseudocyst walls than classical two-dimensional ultrasound scans. The use of subtraction in three-dimensional scans of blood vessels increases the safety in performing biopsies. It makes the aspiration of cytologic materials much safer to perform. In our study we have shown that three-dimensional sonography collects extremely useful information about the status of the pseudocyst structure and it should become a complementary method to classical ultrasonography. This technique when used on a routine basis ought to help us change the inclusion criteria for guided biopsies.

Adult↗
PubMedDate not supplied

[MRI in the diagnosis of congenital white matter diseases and other neurodegenerative diseases].

The results of cranial magnetic resonance imaging in 76 children (aged 3 weeks--17 years) with neurometabolic or other neurodegenerative diseases are presented. The number of diagnosed diseases was 22. MR symptomatology of 11 of them is presented. The list of characteristic images includes metachromatic leukodystrophy, mucopolysaccharidoses, X-linked adrenoleukodystrophy, Leigh, Menkes and Pelizaeus-Merzbacher diseases, glutaric aciduria type I, Canavan disease, neuronal ceroid lipofuscinosis, Hallervorden-Spatz and Huntington diseases. The diagnosis of neurometabolic/neurodegenerative diseases cannot be based on MRI alone but in some of them (metachromatic leukodystrophy, adrenoleukodystrophy, Leigh and Menkes diseases, glutaric aciduria type I, Canavan and Hallervorden-Spatz diseases) MRI can strongly suggest the diagnosis.

Adolescent↗
PubMedDate not supplied

[Corpus callosum pathological lesions in computed tomography and magnetic resonance imaging].

The spectrum of congenital anomalies and other pathologic changes of the corpus callosum is presented. Callosal agenesis and hypoplasia, lesions in cases of congenital neurometabolic disorders, traumatic, vascular, inflammatory and neoplastic conditions as well as callosal atrophy are discussed. CT and MR images from the authors' own experience illustrate the material.

Adolescent↗
PubMedDate not supplied

MR and 1H MR spectroscopy of the brain in patients with liver cirrhosis and early stages of hepatic encephalopathy.

BACKGROUND/AIMS: Hepatic encephalopathy is a serious problem in patients with liver cirrhosis and precise pathophysiological mechanisms responsible for encephalopathy are not fully understood. Magnetic resonance imaging and magnetic resonance spectroscopy can be used to detect specific morphological and metabolic abnormalities in the brain even in patients with early stages of hepatic encephalopathy. METHODOLOGY: Twenty patients with liver cirrhosis and 14 patients with grade I-II hepatic encephalopathy were studied with magnetic resonance and proton magnetic resonance spectroscopy. Localized magnetic resonance spectra were acquired in the parietal gray/white matter regions and basal ganglia. Control group consisted of 20 healthy volunteers. RESULTS: Frequency and degree of brain atrophy and bilateral signal hyperintensities in globus pallidus were similar in groups with liver cirrhosis and with encephalopathy. Decreased myoinositol, choline and increased glutamine levels were noted in both groups whereas N-acetylaspartate levels were unchanged. The statistically significant differences between cirrhotic and encephalopathic groups were observed only in myoinositol/creatine ratio in basal ganglia. There were no significant differences in metabolic concentrations between parietal and basal ganglia regions. CONCLUSIONS: Metabolic brain alterations occur earlier than clinical evidence of hepatic encephalopathy but there is no correlation between presence of symptoms encephalopathy and magnetic resonance and magnetic resonance spectroscopy findings.

Adult↗
PubMedDate not supplied

[Value of computerized tomography and magnetic resonance imaging in difficult diagnosis of the cases of pituitary adenoma].

Thanks to endocrinological and radiological diagnostic improvement and development of pituitary adenoma neurosurgery, CT-examination became a routine examination in such cases, in selected situations supported with MRI-examination. The authors report a short bibliography review of radiologically difficult cases, explained thanks to CT and MRI-examinations.

Adenoma↗
PubMedDate not supplied

[Vertebrobasilar ischemia--clinico-radiologic correlations].

This term is used for describing disturbances of blood flow in the vertebral and basilar arteries due to atherosclerotic lesions causing stenosis or occlusion of these arteries. Clinical patterns of the resulting disturbances include transient symptoms, mainly vertigo, and stabilized syndromes with evidence of brain damage in this blood supply area. The purpose of the study was assessment of the blood flow in this vascular bed by means of dynamic computerized tomography (DCT) in relation to clinical signs, and a comparison of the results with those of similar DCT examinations in cases of circulatory disturbances in the carotid arteries. The study was carried out on 40 patients (20 with stabilized syndromes, 10 with transient disturbances and 10 with ischaemic episodes in the carotid artery supply. DCT abnormalities were found in 90% of patients with stabilized syndromes and in 40% of those with transient ischaemia. DCT may be an auxiliary diagnostic methods and may confirm the presence of vertebrobasilar circulatory failure. Normal result is not ruling out presence of changes in this arterial system.

Adult↗