Search PubMed⌕ Search

Biomedical subjects

J Wagner

Publications and source records attributed to J Wagner.

At least 667 records · Page 37Linked to original sources
PubMedDate not supplied

Deep vein thrombosis in intravenous drug abusers presenting as a systemic illness.

Upper extremity deep venous thrombosis occurred in two patients with a recent history of intravenous drug abuse. Both patients presented with complaints and physical findings consistent with a systemic illness. Evaluation revealed non-septic deep venous thrombosis, and both patients improved with intravenous heparin therapy alone. We propose that non-septic deep venous thrombosis of the upper extremity is another complication of intravenous drug abuse, and that its presentation may masquerade as one of the more well-recognized systemic illnesses associated with drug abuse.

Adult↗
PubMedDate not supplied

The nitroglycerin polymer gel matrix system: a new method for administering nitroglycerin evaluated with plasma nitroglycerin levels.

A new topical dosage form of nitroglycerin has been developed in which nitroglycerin and its vehicle are incorporated in a polymer gel matrix of fixed dimension. Venous plasma nitroglycerin concentrations were measured for 24 h after application of nitroglycerin polymer gel systems measuring 10 cm and containing 2% nitroglycerin (wt/wt) to 10 normal male volunteers. Five of these subjects were subsequently tested with 20-cm2 gel systems of similar composition. With the 10-cm2 nitroglycerin polymer gel system, venous plasma nitroglycerin concentrations were 0.83 +/- 0.26 ng/ml ast 4 h and 0.89 +/- 0.23 ng/ml at 24 h. For the 20-cm2 system, venous plasma nitroglycerin concentrations were 1.83 +/- 0.55 ng/ml at 8 h and 1.81 +/- 0.13 ng/ml at 24 h. The only adverse effect noted was headache, which affected all the subjects tested with the 20-cm2 appliance. The plasma nitroglycerin concentrations obtained with the polymer gel system appear to be in a clinically useful range; thus this new form of topical nitroglycerin should be of benefit to patients in whom sustained plasma nitroglycerin concentrations are desirable, e.g., those patients with chronic congestive heart failure and angina on awakening.

Administration, Topical↗
PubMedDate not supplied

Thermal sensory decision theory indices and pain threshold in chronic pain patients and healthy volunteers.

Fifty-five low back pain patients and 47 healthy volunteers judged the intensity of calibrated thermal stimuli. The method of constant stimuli yielded a pain threshold, and sensory decision theory (SDT) methods provided two independent indices of perceptual performance: discriminability, P(A), the ability to differentiate among various stimulus intensities; and report criterion, B, the tendency to use a particular response. Compared to healthy volunteers, chronic pain patients were far poorer discriminators [lower P(A)]. In addition, the chronic pain patients were more stoical (higher B) and had higher thresholds for reporting both very faint pain and pain. The poor discriminability in patients could be due to attenuation of afferent neural input. The higher criterion suggests that the thermal stimuli were perceived as being innocuous relative to their clinical pain. Comparison of SDT indices with the threshold measures revealed that the pain threshold was highly correlated to the subject's criterion for reporting pain, B, and unrelated to discriminability, P(A).

Adaptation, Physiological↗
PubMedDate not supplied

Homeless children: interdisciplinary drug prevention intervention.

Homelessness among children has been called a national tragedy. Homeless children, by virtue of their unique situation, are particularly vulnerable for early initiation of and sustained participation in substance abuse behaviors. The authors describe homeless children in relation to drug abuse etiology research, discuss current prevention strategies, suggest necessary components of an interdisciplinary prevention curriculum for homeless preschool children, and delineate methods for delivering the curriculum to the children. Nurses, given their unique role in the healthcare delivery system as well as a holistic world view, are in an unparalleled position to facilitate the design and implementation of such curricula.

Child, Preschool↗
PubMedDate not supplied

Test cassette for measuring peak tube potential of diagnostic x-ray machines.

A test cassette employing a modification of the Ardran-Crooks attenuation technique for measuring peak tube potential (and half-value layer) is described. The technique employs a radiographic intensifying screen which is exposed to a hardened x-ray beam. Copper penetrameters are used to determine the attenuator thickness which reduces the light output from the screen to that transmitted by an optical attenuator over an adjacent area of the screen. The test cassette was calibrated by using x-ray machines whose high voltages were measured electrically. The test cassette has a measurement precision of +/- 1 kVp and an accuracy of +/- 3 kVp or better in the range 50-130 kVp for x-ray generators with the same voltage waveform.

Quality Control↗
PubMedDate not supplied

Forces exerted by a conventional dental explorer during clinical examination.

PURPOSE: To measure the range of forces exerted clinically in order to determine whether research in this area uses forces that are similar to those generally seen in a clinical setting. METHODS: A transducer was manufactured consisting of a force measurement sleeve positioned over the handle of a conventional explorer. The sleeve housed 4 strain gauges oriented to detect forces in a vertical and lateral direction. Five experienced dentists performed a full-mouth caries exam on three fully dentate caries-free subjects with the force-detecting probe. RESULTS: The overall average force was 340 +/- 6 (SEM) g with a standard deviation of 218 g and a range of 14-1,006 g. The average number of contacts per tooth was 6.2 +/- 0.2 (SEM) with a standard deviation of 2.7. CONCLUSIONS: The data from this study show that the forces used in previous studies were sometimes greater than the average force, but were still within the observed range of forces.

Analysis of Variance↗
PubMedDate not supplied

The costs of a Medicare prescription drug benefit.

This paper describes a preliminary cost estimate, prepared by the Congressional Budget Office (CBO), of President Clinton's 1999 prescription drug benefit proposal. The CBO estimated that the new benefit would increase net Medicare outlays by $136 billion between 2002 and 2009, although these estimates are highly uncertain. Because the proposal included an annual cap on the amount of the benefit, it did not require consideration of an important effect of a more comprehensive benefit: higher prices for some drugs. Estimates of future proposals for a Medicare prescription drug benefit may require consideration of that pricing effect.

Budgets↗
PubMedDate not supplied

The depression of homeless children: a focus for nursing intervention.

Homelessness continues to be a social problem that many children experience. The loss of a home and all that is familiar to the child may have devastating short- and long-term effects on the child's psychological well-being. Some of these ill effects can potentially be mitigated by prompt nursing intervention. In this article the findings from a descriptive study that investigated 76 homeless school-age children's level of depression as measured with the Children's Depression Inventory are reported. The relevance of these findings for pediatric nurses and nursing interventions specific to this population are discussed.

Child↗
PubMedDate not supplied

Receptacle testers.

Explore the source record for details and available documents.

Electric Wiring↗
PubMedDate not supplied

Street research.

Explore the source record for details and available documents.

Catchment Area, Health↗
PubMedDate not supplied

Pleomorphic T-cell lymphoma with chondropathia tuberosa; a case report and review.

Pleomorphic T-cell-lymphoma (anaplastic IgA-plasma cell tumor) belongs to the group of malignant non-Hodgkin's lymphomas (NHL). The histological and immunophenotypical subtypes differ with genetic and environmental etiologic factors. Lymphomas arise from the clonal proliferation of precursor cells within lymphoid organs with acquired chromosomal abnormalities. Approximately 5% of all primary malignant bone tumors are NHL, the majority of diffuse large B-cell type. Our case history can be regarded as the first published in English language reporting on a pleomorphic T-cell-lymphoma imitating a Chondropathia tuberosa (Tietze's syndrome): The tumor appeared with a tender tumescence over the sternum and a painful swollen left sterno-clavicular joint--as a rule a typical sign for Tietze's syndrome. Only sternal puncture followed by immune histology confirmed an anaplastic IgA-plasma cell tumor. The primary tumor, and later on an osteolysis of cervical vertebrae I-III with a complete destruction of the axis and an affection of the dens atlantis could not be detected by radiographic examinations. Moreover, this tumor infestation could only be depicted by the magnet resonance imaging and the computed tomography. Furthermore, other results of our report are the very rare manifestation of a T-cell lymphoma as a pedicled tumor near the pancreas or of pancreatic origin and the excellent result of an autologous stem cell transplantation. Reviewing the literature, we want to discuss the present scientific and clinical standards of diagnosis, progress and treatment of Chondropathia tuberosa and T-cell lymphoma, and we want to point out some new aspects of both diseases.

Adult↗
PubMedDate not supplied

[Increase of bacterial resistance in human medicine by resistance genes of bacteria from meat supplying animals].

Two different groups of bacteria carrying genes encoding for resistance to antibiotics may be transmitted from animals to humans via food products: a.) obligate infectious agents (enteric pathogens, e.g. Salmonella enterica spp., Campylobacter spp., EHEC) and b) facultative pathogenic species (e.g. E. coli, enterococci). Thus far, it is unknown whether genes encoding for resistance to antibiotics from these bacteria may be transferred to bacteria in normal flora of the host. The transfers of genes encoding for resistance to vancomycin from animal sources to the mucosa of humans has been suggested. Thus, there is a threat that these plasmid-encoded resistance genes may also be transferred to other gram-positive organisms present in the human flora. Vancomycin is the antibiotic in reserve for treatment of infections caused by oxacillin (methicillin) resistant strains of S. aureus and by strains of pneumococcus resistant to penicillin.

Animals↗
PubMedDate not supplied

[Coping with illness in bronchial cancer from the viewpoint of the patients, their relatives and caregivers. A five-level assessment].

The investigation presented in this paper applies multi-level-assessment to emotional state and coping in patients with newly diagnosed bronchogenic carcinoma. Ratings are obtained by the patients themselves, their spouses/children, their physicians, their nurses, and interviewers, independently. Differences seem to override concordances. Patients generally present themselves in a more positive way, i. e. emotionally less disturbed, better adapted, and more successfully coping, than generally perceived by their associates. Discrepancies regarding specific aspects of illness recognition and coping give information about conflicts in both doctor-patient-relationship (e. g. greater amount of trust from the patients' than from the doctors' point of view) and nurse-patient-relationship (nurses claim patients being more aggressive then patients see themselves), as well as social support. Patients and relatives agree in their ratings of certain criteria of adaptation (getting along with the disease, quality of life) and in effective treatment possibilities. On the basis of factor analyses which are computed separately for each rating level, the perceptual structures of the different raters can be elaborated on.

Adaptation, Psychological↗