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Biomedical subjects

J Wada

Publications and source records attributed to J Wada.

At least 163 records · Page 9Linked to original sources
PubMed1985

Interleukin 2 induces synthesis of polypeptides in an interleukin 2-dependent cell line by transcription and translation.

Interleukin 2 (IL 2) is a lymphocyte growth factor capable of inducing the rapid growth of antigen- or mitogen-stimulated T cells. To understand the molecular mechanisms of IL 2 action, we studied the synthesis of cellular polypeptides induced by IL 2. For a homogeneous cell population responsive to IL 2, we used a murine clone of natural killer-like cells, NK 7, which is strictly dependent on exogenous IL 2 for cell viability and growth. NK 7 cells were first kept in culture without IL 2 for 6 h and then labeled for 3 h with [14C]leucine in the presence or absence of 100 U/ml recombinant human IL 2. Analysis of the cellular polypeptides by two dimensional gel electrophoresis and autoradiography revealed that the addition of IL 2 to IL 2-starved NK 7 cells specifically increased the levels of at least ten polypeptides (designated from molecular weight as p94a, p94b, p52, p51a, p51b, p48.5, p36, p34.5, p25.5, and p23). The increases of p52, p25.5, and p23 were inhibited by 5 micrograms/ml actinomycin D, whereas the other seven were virtually unaffected by the drug.

Animals↗
PubMed1985

Blood pressure tracking in Japanese adolescents. Five-year follow-up in Hisayama, Japan.

Blood pressures (BPs) were measured with standardized sphygmomanometers in 434 Japanese boys and girls living in the town of Hisayama. Simultaneously, data on pulse rate, weight and height were obtained. Out of the original 434 subjects, data were obtained repeatedly for 5 years in 280 subjects. BP levels were significantly correlated with weight in those aged 14-15 and also 19-20 years, but correlation coefficients were small. During the 5-year period, the mean systolic and diastolic blood pressure (SBP & DBP) increased significantly in both sexes, but the increments were greater in boys. Both SBP and DBP at 14-15 years of age were significantly correlated with data taken 5 years later for both sexes, and subjects with a higher initial BP (more than 90th percentile of the distribution) tended to have a higher BP after 5 years. SBPs after 5 years were independently correlated with initial SBP levels and changes in QI (D-QI) in both sexes. On the other hand, DBPs after 5 years were independently correlated with initial DBP levels and height for boys, and initial DBP levels and D-QI for girls.

Adolescent↗
PubMed1984

Natural history of borderline hypertension in the Hisayama community, Japan--I. The relative prognostic importance of transient variability in blood pressure.

Long-term prognosis of borderline hypertensives was studied in a prospective population survey carried on since 1961 in the town of Hisayama, Japan. Five consecutive BP recordings on 1621 subjects aged 40 and over were obtained at entry, and the variability in BP between the first and fifth readings was taken into account when classifying the subject into categorical groups. Even with an estimated variability in BP in several measurements on one occasion, a large fluctuation in BP was observed in both the borderline hypertensives and the normotensives. Borderline hypertensives with a transient elevation in BP more frequently died from cardiovascular disease than did those without BP elevation, as estimated by the long-term cumulative mortality. However, there was no difference in the frequency of hypertension-related organ damage between these two groups at entry.

Adult↗
PubMed1984

Writing hand posture and cerebral dominance for speech.

Levy and Reid's claim (1976, 1978) that writing hand/posture is predictive of cerebral dominance was examined in patients who had undergone bilateral sodium Amytal speech testing. Contrary to their prediction, inverted writers showed the same pattern of speech representation as did straight writers.

Adolescent↗
PubMed1984

[Extracorporeal systemic hyperthermia and cis-diamminedichloroplatinum for treatment of patients with advanced cancer].

Extracorporeal systemic hyperthermia was effective in removing pleural effusion or ascites and for pain relief in patients with advanced cancer. The administration of cisplatin was combined with hyperthermia. Partial remission was noted in 18% of the cases. With the use of cisplatin dosage over 1 mg/kg, approximately 50% of cases showed effective results. Cisplatin dosage should be 1.6mg/kg or more when combined with hyperthermia. Renal failure was the most common complication.

Body Temperature↗