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Biomedical subjects

J Wada

Publications and source records attributed to J Wada.

At least 307 records · Page 17Linked to original sources
PubMed1977

Successfully treated cardiac luxation through right pericardium.

A 54-year old laborer suffering from multiple thoracic injuries on his 16th hospital day during the gypsum bandage for his left shoulder suddenly developed circulatory collapse. Emergency angiocardiogram revieled this is caused by cardiac luxation through the right side pleuropericardium. Reposition of the heart and repair of pericardium resulted in normalization of circulatory physiology. Later, he returned to good and active physical condition.

Angiocardiography↗
PubMed1977

Amino acid sequence of an active fragment of potato proteinase inhibitor IIb.

The amino acid sequence of an active fragment of potato proteinase inhibitor IIb was determined by the Edman degradation procedure and the carboxypeptidase technique. Analyses were carried out on peptides derived from the reduced and carboxymethylated active fragment by digestion with trypsin and chymotrypsin. The active fragment consisted of a single polypeptide chain of 40 amino acid residues including 6 half-cystine residues. Degradation of the intact active fragment by trypsin and subtilisin at pH 6.3--6.4 yielded 3 cystine-containing peptides, and sequence analyses of these peptides revealed that the three disulfide linkages are located between Cys(2) and Cys(16), Cys(6) and Cys(28), and Cys(12) and Cys(38). The reactive site peptide bond of inhibitor IIb, a Lys-Ser bond, is located between positions 26 and 27. The overall sequence of the active fragment is compared with that of an active fragment of inhibitor IIa and the "structure-specificity" relationships of both are discussed. Correlation of the fragments to a naturally-occurring low molecular weight inhibitor is also discussed.

Amino Acid Sequence↗
PubMed1977

Carcinoembryonic antigen titers on effusion fluid. A diagnostic tool?

Carcinoembryonic antigen (CEA) has been demonstrated in tumors and body fluids, suggesting that effusion fluid (EF) CEA titer might separate benign and malignant EF. Plasma and EF CEA titers were determined on 141 patients with either benign (86) or malignant (55) EF. Although plasma CEA titers separated patients with either a benign or malignant EF 56% of the time, this separation was better accomplished (90% of the time) using EF CEA (P less than .0001). A malignant EF was associated with an EF CEA titer greater than or equal to ng/ ml or when, in the range 5.0 to 9.9 ng/ml, the EF CEA titer was greater than twice the plasma CEA. Paired plasma and EF CEA titers may aid in determining the benign or malignant origin of an EF.

Ascitic Fluid↗
PubMed1976

A new cannulation method for isolated mitral valve surgery--"apicoaortic-pa" cannulation.

The present paper describes experimental and clinical studies of a new method "Apicoaortic-PA" cannulation for mitral valve surgery. Our experimental study showed that this method was more rapid and more physiological for cardiopulmonary bypass. We used this technique in 55 cases of isolated mitral valve surgery with successful results. Our general philosophy of surgical approach to the mitral valve diseases is also discussed. We advocate the utilization of the "Apicoaortic Pulmonary Artery" cannulation method for clinical use in isolated mitral valve surgery through the left thoracotomy.

Adolescent↗
PubMed1976

Resolution of diffuse membranous changes with remission of nephrotic syndrome.

A case of membranous glomerulonephritis with initial proliferative changes accompanied by nephrotic syndrome was followed up for seven years. With three serially obtained renal biopsy tissues, the regression of the glomerular membranous alterations was confirmed after the remission of nephrotic syndrome. The diagnosis of lupus nephritis was not conclusive but was suggestive. The resolution of the basement membrane seemed to start structurally at the outer, epithelial surface of the membrane with the formation of basement membrane material. The "microtubular structures" in the glomerular endothelial cytoplasm were continuously observed in three renal tissues obtained serially for five years, regardless of the clinical remission and of glomerularstructural resolution.

Adult↗