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Biomedical subjects

J W WILSON

Publications and source records attributed to J W WILSON.

At least 73 records · Page 4Linked to original sources
PubMed1953

Coccidioidomycosis as a tool in the study of granulomatous disease.

In spite of a far-reaching research effort extending over many years the processes by which the human body acquires immunologic resistance to most of the chronic infectious diseases remain obscure. With few exceptions, methods by which such resistance may be artificially produced or stimulated have not been discovered. In coccidioidomycosis there are several instances in which the immunologic reactions seem to be less complicated than those encountered in tuberculosis, for example. More concentrated research in coccidioidomycosis might lead to a better understanding of immunologic processes in general.

Coccidioidomycosis↗
PubMed1953

Primary cutaneous coccidioidomycosis; the criteria for diagnosis and a report of a case.

Study was made of a case of coccidioidomycosis known to have resulted from primary inoculation of the organisms into the skin. Clinical observations and laboratory data were obtained at the time of clinical illness and for a period of five years thereafter. From the information thus obtained and correlation of it with what already was known of coccidioidomycosis, it was concluded that the disease originates very rarely as the result of primary cutaneous inoculation. In most instances lesions suspected to be of this type have actually resulted by dissemination of the organisms to the skin from a previously unrecognized pulmonary focus. Primary cutaneous coccidioidomycotic lesions closely resemble the primary cutaneous lesions (chancres) in other infectious granulomata, such as syphilis, tuberculosis and sporotrichosis. Spontaneous involution should occur within three months and then there should be immunity to reinfection in all but one or two per thousand instances. From these observations certain criteria were evolved by which to determine in a case of coccidioidomycosis with cutaneous manifestations whether or not the infecting organism entered through the skin.

Administration, Cutaneous↗