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Biomedical subjects

J W Thornton

Publications and source records attributed to J W Thornton.

25 records · Page 2Linked to original sources
PubMed1982

Predicting helplessness in human subjects.

A group of 340 college students was administered a 140-item "helplessness" inventory. From this group, 90 were selected as subjects: 30 with extreme high scores, 30 with extreme low scores, and 30 scoring at the mean. Prior to Task 1, they were assigned to one of three experimental conditions: in Condition 1 they received a series of eight solvable Wechsler block designs; in Condition 2 they received a similar task, except that the designs were unsolvable; in Condition 3 they were given an unrelated article to read for the duration of Task 1. Following Task 1, all subjects were transferred to a second task which involved the learning of a 10-choice point-stylus maze. Significance was attained for personality type, experimental treatment, and blocks of Task 2 trials.

Adult↗
PubMed1977

Hyperbaric oxygen in burn management: a controlled study.

Using the methods and protocol outlined, we have found that hyperbaric oxygen functions as a mild antiseptic agent and provides no advantage in the treatment of full-thickness and partial-thickness burns, alone or in combination with topical treatment with silver sulfadiazine. No effects were observed on metabolic balance in the postburn state determined by percentage of weight change, the time to complete healing in partial-thickness burns or the rate of eschar separation and vascular proliferation in granulation tissue formation in full-thickness burns.

Animals↗
PubMed1976

Graft adherence to de-epithelialized surfaces: a comparative study.

Graft adherence may be divided into two distinct phases: Phase I, which is fibrin dependent and Phase II, which begins after 72 hours with fibro-vascular ingrowth or vascular anastomosis with the graft material. Adherence values for autograft, homograft, heterograft, silicone membrane and a modified collagen membrane were evaluated during the fibrin-dependent Phase I period at 5 and 72 hours on dermal, fascial and granulating surfaces on rats. Modified collagen membrane demonstrated a superior adherence at both times tested on dermal and fascial surfaces, while autograft and homograft were significantly more adherent on granulating surfaces at 72 hours. The inert silicone membrane was consistently the least adherent. Granulating surfaces produced the highest adherence values at 5 hours and fascial surfaces at 72 hours. The higher values found with collagen indicate that future research directed toward the production of a synthetic wound dressing or skin should be directed toward biologically derived materials, rather than inert materials. The data supports the concept of the role of fibrin as the bonding factor in Phase I adherence and implies that collagen, rather than elastin, is primarily responsible for early graft adherence.

Animals↗
PubMed1975

Modified collagen membrane as a skin substitute: preliminary studies.

Modified collagen membrane when compared to autograft, homograft, heterograft and silicone polymer membrane, demonstrated a superior adherence on split and full-thickness surfaces, but proved to be an inferior covering for granulating surfaces. Water vapor transport was found to be adequate and adaptable to modification. It was found to be permeable to most commonly used topical antibiotics, and no significant antigenicity could be demonstrated. In a controlled animal burn study, modified collagen membrane proved superior to homograft and heterograft in regard to mortality, time to grafting, bacteriology and autograft take. These studies provide a background for further laboratory and clinical studies now in progress.

Adhesiveness↗