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Biomedical subjects

J W Springer

Publications and source records attributed to J W Springer.

5 recordsLinked to original sources
PubMed1998

Limitations of pediatric donor kidneys for transplantation.

BACKGROUND: The shortage of grafts for kidney transplantation (Tx) has resulted in an expansion of criteria for pediatric donors. However, the limitations of pediatric donors for kidney Tx are not yet clearly established. We investigated the outcomes of recipients with pediatric kidney grafts from Colorado to elucidate the state of pediatric kidney grafts distributed in the nation and to clarify the limitations of pediatric donor kidneys for Tx. METHODS: Between January 1989 and July 1997, 675 organ donors in Colorado were utilized for Tx. Fifty-seven of these (8.4%) were 10 yr old or younger. Thirty-two of the 57 pediatric donors provided kidneys for 50 recipients both inside and outside Colorado. Forty-four of the 50 recipients were followed and are available for this study. RESULTS: Graft survival rates were 85.6, 77.3, 71.3 and 65.4% for 1, 2, 3 to 5, and 6 yr of follow-up, respectively. Thirteen recipients lost the grafts, including three graft losses within 2 wk, due to primary nonfunction, venous and arterial thrombosis. The mean serum creatinine value in 31 recipients with functioning grafts was 1.3 +/- 0.4 mg/dL at the time with follow-up of 45.9 +/- 28.3 months (5-96 months). Six grafts from 13-month to 3-yr-old donors were transplanted en-bloc and 5 of these have survived. Four of the 5 single grafts from 3 to 5-yr-old donors have functioned. Of the 33 grafts from donors aged 6-10 yr, including 30 single and 3 en-bloc grafts, 22 were still functioning. With respect to donor weight, 4 of the 5 en-bloc grafts from donors weighting 9-15 kg, and 6 of the 7 single and the 1 en-bloc grafts from donors weighing 15-20 kg were still functioning. Cold ischemic time (CIT) within 37.5 h was not associated with early graft outcome. CONCLUSIONS: The kidneys from donors 1-3 yr old and/or weighing 9-15 kg could be successfully transplanted en-bloc and those from donors more than 3 yr old and/or weighing 15 kg were best transplanted by single grafts.

Adolescent↗
PubMed1996

Evaluating a successful coroner protocol.

The coroner release rates for the service of a particular organ procurement organization were evaluated through a retrospective analysis, which included the year before (1991), the year during (1992), and the year after (1993) the adoption of a formal protocol for coroner's cases. In 1991, 22 of 55 (40%) coroner cases were denied for donation by the coroner. In 1992 and 1993, 12 of 55 (22%) and 9 of 56 (16%) coroner cases, respectively, were denied for donation. More significantly, in 1991, 4 of 6 (67%) cases of homicidal gunshot wound to the head were denied for donation by the coroner, whereas only 1 of 13 (8%) such cases were denied in 1993. Also in 1991 all closed head injuries (two) from falls were denied for donation by the coroner, whereas in 1993 1 of 8 (12%) closed head injuries was denied for donation. Finally, all 4 of 4 nonaccidental traumas (ie, child abuse) were denied in 1991, but 1 of 2 were released in both 1992 and 1993. Further education and awareness efforts could reduce the rates of coroner denial even more significantly.

Clinical Protocols↗
PubMed1994

Decreasing the organ donor shortage by increasing communication between coroners, medical examiners and organ procurement organizations.

In 1991, 22 potential organ donors in Colorado were lost due to coroner refusal. This reflects a 41% loss of organ donors in Colorado based on 53 donors for the same year, which prompted Colorado Organ Recovery Systems to ascertain whether there was a national trend in coroner/medical examiner refusal of potential organ donors. A survey was developed to determine the release rates of investigators for the six most common scenarios that lead to organ donation. These surveys were mailed to each organ procurement organization in the United States and were returned by 55 (82%) of them. Coroners were found to release cases for organ donation approximately one-half as often as medical examiners. Child abuse (nonaccidental trauma) is the category least often released, with coroners releasing only 8% of the time, while suicide is the category most often released (still, only 54% of the time). Different investigators in the same areas are consistent approximately 72% of the time. These figures, when presented to a task force, initiated the development of a protocol for organ and tissue donation for coroners' cases in Colorado. Early results of the protocol include the coroners' release of six organ donor cases since its introduction.

Colorado↗
PubMed1976

Adjuvant effects of diethylaminoethyl-dextran.

Diethylaminoethyl-dextran exhibited a significant effect on the primary immune response of rhesus monkeys to formalin-inactivated Venezuelan equine encephalomyelitis virus vaccine (IVEE). Antibody formed to IVEE and adjuvant followed a classic immunoglobulin M-immunoglobulin G pattern; however, as compared with vaccine alone, use of this adjuvant with IVEE reduced the time required for onset of immunoglobulin G synthesis.

Adjuvants, Immunologic↗