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Biomedical subjects

J W Sharp

Publications and source records attributed to J W Sharp.

At least 37 records · Page 2Linked to original sources
PubMed1986

Social work in a home intravenous antibiotic therapy program.

Home intravenous antibiotic therapy (HIVAT) grew out of one hospital's experience with home parenteral nutrition. Because of current accelerated pace of discharge planning, the social worker plays a major role in choosing appropriate candidates for this program and in helping them solve practical and affective problems. Patients report a high degree of satisfaction with this homecare plan. Benefits such as early return to employment are noted. Shortened hospital stays lower treatment costs. The program is adaptable for many patients where medical treatment initiated in the hospital continues at home.

Adult↗
PubMed1985

Directing the post-TEFRA laboratory.

Strategies of the past are inappropriate for the future. But pathologists and hospitals who know the options and take the necessary steps can survive prospective payment.

Costs and Cost Analysis↗
PubMed1979

Acute lymphoblastic leukemia, hand-mirror variant. A detailed ultrastructural study.

The hand-mirror cell in acute lymphoblastic leukemia may have important immunologic, pathogenic, and prognostic implications. To learn more about this cell, a detailed ultrastructural analysis was performed. Fifty electronmicrographs of lymphoblasts from an untreated patient with acute lymphoblastic leukemia with numerous hand-mirror cells in the bone marrow were compared with 60 electronmicrographs of lymphoblasts from six patients with classic acute lymphoblastic leukemia. The unique qualitative ultrastructural features of the hand-mirror cells were the presence of undamaged mitochondria and uropods (handles) with terminal microspikes containing circular organized arrangement of 50-A microfilaments. Quantitative differences between hand-mirror cells and lymphoblasts were observed in nuclear perimeters (P less than 0.0001), nuclear lengths (P less than 0.001), cytoplasmic lengths (P less than 0.0002), nuclear-cytoplasmic length ratios (P less than 0.0001), and numbers of mitochondria (P less than 0.002). These findings indicate that hand-mirror cells contain ultrastructural components that are related to cell motility and the immunologic process. These results are significant in that the hand-mirror cells may be associated with an immunologic mechanism that is involved in leukemogenesis.

Cell Nucleolus↗
PubMed1976

Anthelmintic efficacy of mebendazole for pinworm infection of mice.

A series of 6 experiments was conducted to test the efficacy of mebendazole in eliminating naturally occurring pinworm infections from mice. Subjects treated with from 40-500 mg/kg of the drug harbored markedly fewer parasites than untreated controls. Treatment at 10 mg/kg appeared to be less effective. No mortality or overt signs of toxicity were observed in any of the experimental subjects.

Animals↗
PubMedDate not supplied

Home parenteral nutrition in advanced cancer.

The use of home parenteral nutrition (HPN) in advanced cancer evokes ethical problems related to risk/benefit, patient autonomy, justice, medical futility, and cost. Case series have been beneficial for some patients, particularly when survival is expected to be longer than 2 months. A team approach to involving the patient and family in evaluating risk and benefits is preferred. Social workers serve a key role in enabling the patient and family to make end-of-life decisions by helping them clarify the psychosocial and ethical aspects of these decisions. Clinical standards and case law will further define whether HPN in advanced cancer is futile treatment. Broader social issues of rationing, access to HPN, and costs must be addressed. Further research on outcomes and patient/family decision making on HPN are needed.

Beneficence↗